Aggressive NK cell lymphoma/leukemia with clonal der(3)t(1;3) (q12;p25), del(6)(q13) and del(13)(q12q14)

Hamaguchi, Hiroyuki; Yamaguchi, Mitsuko; Nagata, Kaoru; Koike, Eriko; Imagunbai, Masaru; Tsurukubo, Yoshito; Yamamoto, Katsuya

doi:10.1016/s0165-4608(01)00474-5

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…Four cases were identified using a PubMed search from 1968 to 2008 with the following key words: natural killer cell, natural killer cell leukemia, large granular lymphocyte leukemia and natural killer cell lymphoma [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. Cases with a history of chronic NK lymphocytosis were excluded.…”

Section: Methodsmentioning

confidence: 99%

Aggressive Natural Killer Cell Leukemia: Is Epstein-Barr Virus Negativity an Indicator of a Favorable Prognosis?

Ko¹,

Park

Kım

et al. 2008

Acta Haematol

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Aggressive natural killer (NK) cell leukemia (ANKL) is a prototype of an Epstein-Barr virus (EBV)-associated lymphoid malignancy, which is characterized by a fulminant clinical course and a median survival interval <2 months. EBV negativity in ANKL is uncommon, and the characteristics of EBV-negative ANKL are not well defined. We compared the clinicopathological characteristics of EBV-negative ANKL patients (group 1, n = 2) with those of EBV-positive ANKL patients (group 2, n = 14) and reviewed the literature for reports on EBV-negative ANKL cases. EBV-negative and EBV-positive ANKL patients had similar clinical and pathological characteristics, but EBV-negative patients had a longer survival than EBV-positive patients (11.5 vs. 1.5 months, respectively). EBV-negative patients achieved complete remission, but tumors often relapsed after a short interval. In conclusion, EBV-negative ANKL is an uncommon malignancy that pursues a less aggressive clinical course than EBV-positive ANKL.

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Section: Methodsmentioning

confidence: 99%

Aggressive Natural Killer Cell Leukemia: Is Epstein-Barr Virus Negativity an Indicator of a Favorable Prognosis?

Ko¹,

Park

Kım

et al. 2008

Acta Haematol

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“…The Oncologist ® abnormality in patients with aggressive NK-cell LGL leukemia is the deletion of the 6q chromosome, but cases with complex karyotypes have also been reported [35,36].…”

Section: Immunophenotypementioning

confidence: 99%

Large Granular Lymphocyte Leukemia

2006

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“…Literature review To compare our ¢ndings with previous published cytogenetic data, we have collated the G-banded karyotypes of peripheral T cell lymphoma/natural killer cell lymphoma, nonspeci¢c, blastic natural killer cell lymphoma (CD4 þ CD56 þ DC2), extranodal natural killer-like T cell lymphoma, nasal type (natural killer/TCL), and aggressive natural killer cell lymphoma/leukemia (aggressive natural killer cell lymphoma/ leukemia) through an extensive literature search (Fernandez et al, 1986;Koizumi et al, 1986;Bassan et al, 1988;Sheridan et al, 1988;Taniwaki et al, 1990;Hart et al, 1992;Sun et al, 1992Sun et al, , 1993Oshimi et al, 1993;Gelb et al, 1994;Brody et al, 1995;Shimodaira et al, 1995;Wong et al, 1995Wong et al, , 1997Wong et al, , 1999Wong et al, , 2000Callet-Bauchu et al, 1997;DiGiuseppe et al, 1997;Suzuki et al, 1997;Tien et al, 1997;Kameoka et al, 1998;Petrella et al, 1999;Zhang et al, 1999;Hamaguchi et al, 2001;Leroux et al, 2002;Mitelman Database of Chromosome Aberrations in Cancer, 2002). All chromosome aberrations were grouped into chromosomal losses and gains, and structural rearrangements.…”

Section: Samplesmentioning

confidence: 99%

“…Previous cytogenetic studies have shown a variety of nonrandom chromosomal abnormalities in natural killer cell lymphomas (Fernandez et al, 1986;Bassan et al, 1988;Taniwaki et al, 1990;Hart et al, 1992;Oshimi et al, 1993;Gelb et al, 1994;Brody et al, 1995;Callet-Bauchu et al, 1997;Tien et al, 1997;Kameoka et al, 1998;Petrella et al, 1999;Wong et al, 1999;Zhang et al, 1999;Hamaguchi et al, 2001;Leroux et al, 2002); however, unlike nodal non-Hodgkin's lymphoma, no recurrent chromosome translocations have been identi¢ed in this malignancy.…”

mentioning

confidence: 98%

Genomic Alterations in Blastic Natural Killer/Extranodal Natural Killer-Like T Cell Lymphoma with Cutaneous Involvement

Mao

Onadim²,

Price³

et al. 2003

Journal of Investigative Dermatology

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Natural killer and natural killer-like T cell lymphomas represent a rare type of non-Hodgkin's lymphoma originally described to involve the upper aerodigestive tract. This malignancy has been increasingly observed in other extranodal sites, particularly in the skin. Patients with cutaneous natural killer cell lymphoma generally have a poor prognosis; however, the etiology and the underlying molecular pathogenesis remain unclear. This study aimed to investigate comprehensively genomic changes in blastic natural killer and extranodal natural killer-like T cell lymphoma with cutaneous involvement. Comparative genomic hybridization showed chromosome imbalances in six of eight cases studied (75%). The mean number of chromosome imbalances per sample was 2.18+/-1.63 with similar number of gains (1.18+/-1.17) and losses (1.00+/-1.34). The most frequent DNA copy number changes observed were losses of 9/9p (83%), followed by loss of 13q and gain of 7 (67%). Similar patterns of chromosome imbalances were observed in both blastic natural killer and cutaneous natural killer-like T cell lymphomas. Loss of the RB1 gene at 13q14.2 was detected in one blastic natural killer cell lymphoma with 13q loss using a gene dosage assay, and in one cutaneous natural killer-like T cell lymphoma without 13q loss using fluorescent in situ hybridization. Genomic microarray analysis identified oncogene copy number gains of PAK1 and JUNB in three of four cases studied, and gains of RAF1, CTSB, FGFR1, and BCR in two cases. Real-time polymerase chain reaction detected amplification of CTSB and RAF1 in four of five cases analyzed, JUNB and MYCN in three cases, and REL and YES1 in two cases, respectively. In conjunction with this study, an extensive literature search for the published G-banded karyotypes of four subsets of natural killer cell lymphomas was conducted, which showed a nonrandom pattern of multiple chromosome aberrations. These results reveal consistent genetic alterations in cutaneous natural killer cell lymphomas, and provide a basis for further investigation of molecular pathogenesis in this malignancy.

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Aggressive NK cell lymphoma/leukemia with clonal der(3)t(1;3) (q12;p25), del(6)(q13) and del(13)(q12q14)

Cited by 8 publications

References 28 publications

Aggressive Natural Killer Cell Leukemia: Is Epstein-Barr Virus Negativity an Indicator of a Favorable Prognosis?

Aggressive Natural Killer Cell Leukemia: Is Epstein-Barr Virus Negativity an Indicator of a Favorable Prognosis?

Large Granular Lymphocyte Leukemia

Genomic Alterations in Blastic Natural Killer/Extranodal Natural Killer-Like T Cell Lymphoma with Cutaneous Involvement

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