Aggressive Palliation and Survival in Anaplastic Thyroid Carcinoma

Nachalon, Yuval; Stern-Shavit, Sagit; Bachar, Gideon; Shvero, Jacob; Limon, Dror; Popovtzer, Aron

doi:10.1001/jamaoto.2015.2332

Cited by 48 publications

(50 citation statements)

References 25 publications

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“…This difference may explain the more favourable 2-year survival rate in the study of Foote et al when compared to the 2-year-survival rate in our study (8). Aggressive treatment strategies including surgery, chemotherapy and radiotherapy have been suggested to improve survival in patients with ATC (13). This finding agreed well with the result of our study that the use of concurrent chemotherapy in addition to radiotherapy improved survival.…”

Section: Discussionsupporting

confidence: 89%

Prognostic Factors for Survival in Patients Treated with Multimodal Therapy for Anaplastic Thyroid Cancer

Käsmann

Bolm

Rades

2016

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Section: Discussionsupporting

confidence: 89%

Prognostic Factors for Survival in Patients Treated with Multimodal Therapy for Anaplastic Thyroid Cancer

Käsmann

Bolm

Rades

2016

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“…In the multivariable analysis, single‐modality treatment was associated with increased risk of death (HR 2.996, 95% CI 1.2‐7.1, P = .013). A smaller series from Israel of 26 patients, evaluating three different RT dose levels showed similar results . Longer median OS was seen with the use of chemotherapy vs none (11 vs 4 months, P = .01), and treatment with chemoradiation vs aggressive palliative RT dose vs conventional palliative RT (11 vs 6 vs 3 months, P < .001).…”

Section: Discussionmentioning

confidence: 71%

Survival advantage of chemoradiotherapy in anaplastic thyroid carcinoma: Propensity score matched analysis with multiple subgroups

et al. 2019

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Background We compared overall survival (OS) between radiation therapy (RT) and chemoradiotherapy (CRT) in patients with anaplastic thyroid carcinoma (ATC) using a large database. Methods The National Cancer Data Base was queried for ATC patients diagnosed between 2004 and 2013 who received RT or CRT. Groups were balanced by propensity score matching (PSM) on nine relevant variables. OS was also examined in five paired subgroups given known patient heterogeneity. Results Of 858 total patients, 575 received CRT and 283 received RT. CRT was associated with decreased risk of death (hazard ratio [HR] 0.66, P < .001), 1‐year OS 25.5% vs 14.3%. A survival advantage to CRT was seen using PSM cohorts (HR 0.75, P = .006). Those receiving definitive surgery saw the greatest benefit to CRT over RT (HR 0.65, P = .009), 1‐year OS 39.6% vs 20.4%. Conclusions CRT is associated with decreased risk of death in ATC; the magnitude of CRT vs RT benefit varied by subgroup.

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“…It is the most lethal form of thyroid malignancies, with a high rate of regional and distant spread and a grave prognosis (2)(3)(4). Primary thyroid lymphoma (PTL) is also an uncommon disease, representing less than 5% of thyroid malignancies.…”

Section: Introductionmentioning

confidence: 99%

Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma

Gu¹,

Cui²,

Wang³

et al. 2017

J. Thorac. Dis.

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Background: Although primary thyroid lymphoma (PTL) and anaplastic thyroid carcinoma (ATC) both account for a rare portion of the morbidity of all thyroid malignancies, the therapeutic methods and prognosis for these two diseases are different. The purpose of this study was to investigate the sonographic characteristics of PTL and ATC and to compare the sonographic findings of PTL and ATC. Methods:The study included 42 patients with histopathologically proven PTL (n=27) and ATC (n=15). The Clinical characteristics and sonographic findings were retrospectively reviewed and compared between the two groups.Results: The mean age of patients with ATC was not significantly different from that in patients with PTL (P=0.601). The female-to-male ratio of patients with ATC was significantly lower than that of patients with PTL (P=0.029). Both PTL and ATC commonly present as a relatively large, solid mass on sonography with compressive symptoms, in which hoarseness was seen more frequently in ATC group (66.7%) than in PTL group (14.8%) (P=0.001). There is no significant difference in thyroid size, nodular size, margin, shape, echo texture, echogenicity, cystic change, vascularity and local invasion on sonography between ATC and PTL groups. Echogenic strands, markedly hypoechoic and enhanced posterior echo were seen more frequently in PTL group (92.6%, 92.6%, and 85.2%, respectively) than those in ATC group (6.7%, 60.0%, and 33.3%, respectively) (P<0.05), and calcification was seen more frequently in ATC group (80.0%) than in PTL group (0%) (P<0.001). Three ultrasound patterns were observed for PTL including diffuse type (25.9%), nodular type (48.2%) and mixed type (25.9%), while all ATC cases presented with nodular type (100.0%). AssociatedHashimoto's thyroiditis occurred more frequently in PTL group (59.3%) than in ATC group (20.0%) (P=0.023). Conclusions: Certain sonographic features as a markedly hypoechogenicity, the presence of an enhanced posterior echo and linear echogenic strands, lack of calcification and associated Hashimoto's thyroiditis were valuable for distinguishing PTL from ATC. In contrast, heterogeneous echogenicity, uncircumscribed margin, irregular shape, and vascular pattern were not specific features for differential diagnosis.

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Aggressive Palliation and Survival in Anaplastic Thyroid Carcinoma

Cited by 48 publications

References 25 publications

Prognostic Factors for Survival in Patients Treated with Multimodal Therapy for Anaplastic Thyroid Cancer

Prognostic Factors for Survival in Patients Treated with Multimodal Therapy for Anaplastic Thyroid Cancer

Survival advantage of chemoradiotherapy in anaplastic thyroid carcinoma: Propensity score matched analysis with multiple subgroups

Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma

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