Aggressive Posterior Retinopathy of Prematurity: Risk Factors for Retinal Detachment Despite Confluent Laser Photocoagulation

Sanghi, Gaurav; Dogra, Mangat R; Katoch, Deeksha; Ak, Gupta

doi:10.1016/j.ajo.2012.07.012

Cited by 63 publications

(67 citation statements)

References 13 publications

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“…On the other hand, laser treatment is a highly destructive procedure in APROP in which the majority of retinal tissue is ablated preventing the growth of vessels peripherally from the point of treat ment. Further, a risk of retinal detachment has been reported even after successful laser treat ment in such cases (2,16) . We observed 2 eyes with Zone I APROP that progressed to stage 4A retinal detachment following laser ablation, which remained stable during the study follow-up period.…”

Section: Discussionmentioning

confidence: 99%

“…These studies demonstrated laser photocoagulation results in better anatomic results and causes lower de grees of myopia than cryoablation (17)(18)(19) . However, laser treatment for APROP has been shown to be associated with a range of unfavora ble anatomic and functional outcomes depending on disease severity (2,3,20) . The introduction of IVB to ROP therapy has allowed the majority of cases of APROP to be salvaged with successful anatomic outcomes (6,9,21) .…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of APROP is clinically important in ensuring timely intervention as APROP can rapidly progress to tractional retinal detachment (2) . Further, higher rates of unfavorable structural and refractive outcomes have been reported following laser ablation and cryoablation for the treatment of APROP (3)(4)(5) .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of 2-year outcomes following intravitreal bevacizumab (IVB) for aggressive posterior retinopathy of prematurity

Günay¹,

Çelik²,

Günay³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Zeynep Kamil Maternity and Children's Disease Training and Research Hospital. ABSTRACTPurpose: To evaluate 2-year outcomes following intravitreal bevacizumab (IVB) as monotherapy for aggressive posterior retinopathy of prematurity (APROP). Methods: Medical records of 40 infants were retrospectively reviewed. Group I included infants who had received IVB injections for APROP. Group II included infants who underwent laser treatment for APROP. Anatomic and refractive outcomes and the presence of anisometropia and strabismus were assessed at follow-up examinations. Results: Group I included 48 eyes of 25 infants (11 males) with a mean gestational age (GA) of 26.40 ± 1.82 weeks and a mean birth weight (BW) of 901.40 ± 304.60 g. Group II included 30 eyes of 15 infants (6 males) with a mean GA of 27.30 ± 1.82 weeks and a mean BW of 941.00 ± 282.48 g. GA, BW, and gender distributions were similar between groups (P=0.187, P=0.685, and P=1.000, respectively). Refractive errors were significantly less myopic in group I (0.42 ± 3.42 D) than in group II (-6.66 ± 4.96 D) at 2 years (P=0.001). Significantly higher rates of anisometropia and strabismus were observed in group II than in group I (P=0.009 and P=0.036, respectively). Conclusions:The study demonstrated that IVB monotherapy can be useful in the treatment of APROP. The decreased incidence of early unfavorable refractive and functional outcomes in the IVB group compared with the laser group showed a potential benefit for patients treated with IVB, and this needs to be better evaluated in future prospective studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of 2-year outcomes following intravitreal bevacizumab (IVB) for aggressive posterior retinopathy of prematurity

Günay¹,

Çelik²,

Günay³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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show abstract

“…We halted the procedure and rearranged a second laser session in order to complete laser ablation of the remaining avascular zones. Although divided laser sessions were mostly reported in aggressive posterior ROP (APROP) cases due to inadequate regression of the disease [18], gradual worsening of ocular surface findings in the present case compelled us to perform LPC in two laser sittings. Actually, this seemed to be an effective method in our case.…”

Section: Discussionmentioning

confidence: 92%

Treatment for Retinopathy of Prematurity in an Infant with Adenoviral Conjunctivitis

Günay

Çelik

Con

2015

Case Reports in Pediatrics

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Retinopathy of prematurity (ROP) has been a major problematic disorder during childhood. Laser photocoagulation (LPC) has been proven to be effective in most of the ROP cases. Adenoviral conjunctivitis (AVC) is responsible for epidemics among adult and pediatric population. It has also been reported to be a cause of outbreaks in neonatal intensive care units (NICU) several times. We herein demonstrate a case with AVC who underwent LPC for ROP. And we discuss the treatment methodology in such cases.

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“…[7][17] Preretinal hemorrhages and new-onset fibrovascular traction especially after laser is associated significantly with development of retinal detachment. [19] In the aggressive posterior retinopathy of prematurity (APROP), the group for early treatment of ROP (ET-ROP) [10] reported 15% unfavorable functional outcome and 10% unfavorable structural outcome with laser, due to the development of retinal folds, retinal detachment, and retrolental fibroplasia. Over the last years, the intravitreal injection of antivascular endothelial growth factor (VEGF) has become increasingly popular in treatment of ROP.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Aggressive Posterior Retinopathy of Prematurity in a Tertiary Care Hospital in South India

Sathar¹

2017

jmscr

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Aggressive Posterior Retinopathy of Prematurity: Risk Factors for Retinal Detachment Despite Confluent Laser Photocoagulation

Cited by 63 publications

References 13 publications

Evaluation of 2-year outcomes following intravitreal bevacizumab (IVB) for aggressive posterior retinopathy of prematurity

Evaluation of 2-year outcomes following intravitreal bevacizumab (IVB) for aggressive posterior retinopathy of prematurity

Treatment for Retinopathy of Prematurity in an Infant with Adenoviral Conjunctivitis

Outcome of Aggressive Posterior Retinopathy of Prematurity in a Tertiary Care Hospital in South India

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