Aggressive T/Natural killer cell lymphoma presenting as testicular tumor

Chan, John K. C.; Tsang, William Y.W.; Lau, W.S.; Cheung, Moon‐Tong; Ng, Wing-Fung; Yuen, Wai–Cheung; Ng, Chi-Sing

doi:10.1002/(sici)1097-0142(19960315)77:6<1198::aid-cncr29>3.0.co;2-w

Cited by 83 publications

(21 citation statements)

References 32 publications

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“…Surface expression of CD3 was detected in a single tumor, which also expressed CD8, suggesting a cytotoxic T-cell phenotype. 16 Expression of CD4 was unusual in this series (n = 1), as was the expression of the pan T-cell markers CD5 (n = 0) and CD7 (n = 2). CD30 was weakly positive in 1 of 7 tumors tested for this antigen, 22 whereas 4 of 5 tumors tested expressed CD43, a molecule involved in normal NK-cell adhesion and signal transduction.…”

Section: Resultsmentioning

confidence: 75%

“…2,5,[10][11][12][13][14][15][16][17][18][19][20][21][22] Four publications were excluded from the primary analysis: 1 case of blastic NK lymphoma in the setting of testicular feminization and germ cell tumor, 12 1 case of CD56 -peripheral T-cell lymphoma, 13 1 case of nonhepatosplenic gamma/delta T-cell lymphoma, 14 and 1 case that appeared to have been reported previously. 2 One additional publication reported on 3 cases of testicular NK or T-cell lymphoma, among which we have excluded 1 from the primary analysis for being CD56 -.…”

Section: Resultsmentioning

confidence: 99%

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Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis

2008

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Primary nasal-type natural killer/T-cell lymphoma of the testis is a rare malignancy. Although dissemination to the testis from other sites occurs somewhat more frequently than a primary presentation, even secondary testicular involvement is uncommon. In this article, the authors report on the comprehensive histopathologic, immunohistochemical, and molecular analysis of a case of primary testicular nasal-type natural killer/T-cell lymphoma, and review the features of 16 previously reported patients. The investigation carried out in this study indicates that the testicular nasal-type natural killer/T-cell lymphomas occur at a younger age than their B-cell counterparts, express cytoplasmic CD3 and surface CD56, and consistently show an infection by Epstein-Barr virus. These tumors have variable expression of T-cell antigens other than cytoplasmic CD3 and may show monoclonal rearrangement of T-cell receptor genes. Testicular natural killer/T-cell lymphomas of nasal type invariably follow an aggressive clinical course.

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Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis

2008

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“…To the best of our knowledge, there are 10 reported cases of extranodal NK/T-cell lymphoma involving the stomach, and the lesions were not limited to the stomach in any of these cases. [17][18][19][20][21] Second, although some of the cases of LyGa showed necrosis, but angiocentric or angiodestructive growth patterns, and prominent apoptotic bodies, which are common features of extranodal NK/T-cell lymphoma, 1 were not observed. Third, LyGa may show epithelial invasion, that is, lymphoepithelial-like lesion by NK cells.…”

Section: Discussionmentioning

confidence: 99%

Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation

Takeuchi

Yokoyama

Ishizawa

et al. 2010

Blood

109

128

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“…The preferential site of NK/T-cell lymphomas in certain extranodal areas is the nasal cavity, but they also occur in the central nervous system, gastrointestinal tract, skin, salivary gland and testis [6,8,22,25,31,32]. The oral cavity is a rare site of occurrence.…”

Section: Discussionmentioning

confidence: 99%

Primary natural killer/T-cell lymphomas of the oral cavity are aggressive neoplasms

et al. 1999

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Thirty-four cases of primary non-Hodgkin's lymphoma of the oral cavity were investigated for their clinical findings, histopathological features, immunophenotypes and association with Epstein-Barr virus (EBV). Four cases (12%) were natural killer/T-cell lymphomas, 3 (9%) were T-cell lymphomas and 27 (79%) were Bcell lymphomas. Compared with T-and B-cell lymphomas, NK/T-cell lymphomas had a male predominance (M:F 4:0), and most presented as ulceration of the palate and/or maxillary gingiva. Histologically, the lesions showed diffuse infiltration of medium-sized or large lymphoid tumour cells. Angiocentricity and/or angioinvasion were found in all 4 cases. The immunophenotypes of the NK/T-cell lymphomas were CD3+, CD43+, CD45RO+, CD56+ and TIA-1+. EBV was detected in 2 NK/T-cell lymphomas by in situ hybridization (ISH) and polymerase chain reaction (PCR) methods, and was not detected in T-and B-cell lymphomas. The survival rate of patients with NK/T-cell lymphoma was zero, but the survival rates for patients with T-cell and B-cell lymphomas were 67% and 38%, respectively. It appears that NK/T-cell lymphomas of the oral cavity have a predilection for originating in the palate and maxillary gingiva and are aggressive neoplasms. EBV positivity might be associated with more aggressive behaviour.

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Aggressive T/Natural killer cell lymphoma presenting as testicular tumor

Cited by 83 publications

References 32 publications

Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis

Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis

Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation

Primary natural killer/T-cell lymphomas of the oral cavity are aggressive neoplasms

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