Agile Detection of Chemical Warfare Agents by Machine Vision: a Supramolecular Approach

Tuccitto, Nunzio; Catania, G; Pappalardo, Andrea; Sfrazzetto, Giuseppe Trusso

doi:10.1002/chem.202102094

Cited by 16 publications

(18 citation statements)

References 31 publications

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“…Firstly, we tested the response of our sensor to some important analytes contained in the human saliva ( Figure 4 ) [ 59 ]. In particular, we exposed test strip to DA (0.1 nM), uric acid (20 μM), adrenaline (0.1 nM), testosterone (0.1 pM), glucose (72 μM), creatinine (1 μM) and some metal cations (Mg 2+ , Ca 2+ , Mn 2+ , Fe 2+ , Cu 2+ , Zn 2+ ), dissolved in artificial saliva [ 60 ]. DA and adrenaline led to an enhancement of the emission, significant only in the case of DA.…”

Section: Resultsmentioning

confidence: 99%

Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor

et al. 2022

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Supramolecular recognition of dopamine by two quinoxaline cavitands was studied in solution by fluorescence titrations, ESI-MS and ROESY measurements. In addition, the tetraquinoxaline cavitand was dropped onto a siloxane-based polymeric solid support, obtaining a sensor able to detect dopamine in a linear range of concentrations 10 Mm–100 pM, with a detection limit of 1 pM, much lower than the normal concentration values in the common human fluids (plasma, urine and saliva), by using a simple smartphone as detector. This sensor shows also good selectivity for dopamine respect to the other common analytes contained in a saliva sample and can be reused after acid–base cycles, paving the way for the realization of real practical sensor for human dopamine detection.

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Section: Resultsmentioning

confidence: 99%

Smartphone-Based Dopamine Detection by Fluorescent Supramolecular Sensor

et al. 2022

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“…We noted that fluorescent probes show, in general, different behavior from solution to solid-state studies. This phenomenon is not unusual, probably due to different aggregation phenomena that occur from the solution to solid phases. , …”

Section: Selectivity Testsmentioning

confidence: 88%

“…This phenomenon is not unusual, probably due to different aggregation phenomena that occur from the solution to solid phases. 24,42 To demonstrate the suitability of this device in real sample analysis, we tested the ability to detect TNT in a mixture with agricultural soil (to simulate the presence of TNT in a land) and food flour (in some terroristic scenarios, the explosives are smuggled into food supplies). In particular, we mixed 100 mg of TNT with 500 g of the real matrix (soil or flour), thus obtaining a sample containing the 0.02% of TNT.…”

Section: ■ Selectivity Testsmentioning

confidence: 99%

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Smartphone-Assisted Sensing of Trinitrotoluene by Optical Array

et al. 2022

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Here we report the design and fabrication of an array-based sensor, containing functionalized Carbon Dots, Bodipy’s and Naphthalimide probes, that shows high fluorescence emissions and sensitivity in the presence of low amounts of TNT explosive. In particular, we have fabricated the first sensor device based on an optical array for the detection of TNT in real samples by using a smartphone as detector. The possibility to use a common smartphone as detector leads to a prototype that can be also used in a real-life field application. The key benefit lies in the possibility of even a nonspecialist operator in the field to simply collect and send data (photos) to the trained artificial intelligence server for rapid diagnosis but also directly to the bomb disposal unit for expert evaluation. This new array sensor contains seven different fluorescent probes that are able to interact via noncovalent interactions with TNT. The interaction of each probe with TNT has been tested in solution by fluorescence titrations. The solid device has been tested in terms of selectivity and linearity toward TNT concentration. Tests performed with other explosives and other nitrogen-based analytes demonstrate the high selectivity for TNT molecules, thus supporting the reliability of this sensor. In addition, TNT can be detected in the range of 98 ng∼985 μg, with a clear different response of each probe to the different amounts of TNT.

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“…Toward this goal, many analytical methods based on chromatography, mass spectrometry, and spectroscopy have been constructed for the detection of OPNAs or simulants. [6][7][8][9][10][11][12][13][14][15][16][17] Nevertheless, the molecular differences between known OPNAs are very tiny. For example, sarin (GB), soman (GD), cyclosarin (GF) and VX only have a small variation in one or two substitution groups.…”

Section: Introductionmentioning

confidence: 99%