Aging affects l-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels

Rushaidhi, M.; Yu, Jing; Kennard, Jeremy T.; Collie, Nicola D.; Williams, Joanna M.; Zhang, H.; Liu, P.

doi:10.1016/j.neuroscience.2012.02.021

Cited by 34 publications

(22 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurochemical studies, however, have indicated that several different amino acids, including glutamate (Liu et al, 2009; Rushaidhi et al, 2012), and polyamines necessary for normal cellular function (Liu et al, 2008) show altered levels in the perirhinal of aged rats compared to young animals. Moreover, there is evidence that aged rats have reduced levels of the calcium-binding protein calbindin in the perirhinal cortex, which suggests potential impairments in calcium homeostasis within this brain region (Moyer et al, 2011).…”

Section: Object Recognition and The Perirhinal Cortex: Animal Experimmentioning

confidence: 99%

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

Burke¹,

Ryan²,

Barnes³

2012

Front. Ag. Neurosci.

View full text Add to dashboard Cite

Analyses of complex behaviors across the lifespan of animals can reveal the brain regions that are impacted by the normal aging process, thereby, elucidating potential therapeutic targets. Recent data from rats, monkeys, and humans converge, all indicating that recognition memory and complex visual perception are impaired in advanced age. These cognitive processes are also disrupted in animals with lesions of the perirhinal cortex, indicating that the the functional integrity of this structure is disrupted in old age. This current review summarizes these data, and highlights current methodologies for assessing perirhinal cortex-dependent behaviors across the lifespan.

show abstract

Section: Object Recognition and The Perirhinal Cortex: Animal Experimmentioning

confidence: 99%

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

Burke¹,

Ryan²,

Barnes³

2012

Front. Ag. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The absence of morphological changes in the cell bodies of hippocampal neurons, including accumulation or aggregation of nuclei and shrinking or swelling of the cell bodies, indicates that the axonal degeneration we observed in vitamin E-deficient and normal old mice was an early event that occurred before the induction of cell death. It is well known that the hippocampal CA1 region plays a pivotal role in cognitive function (25,26), and it is possible that axonal degeneration of the hippocampal CA1 region of vitamin E-deficient and old mice is one of the mechanisms underlying cognitive dysfunction in these models.…”

Section: Axonal Degeneration In the Hippocampal Ca1 Region Of Vitaminmentioning

confidence: 99%

Vitamin E Deficiency Induces Axonal Degeneration in Mouse Hippocampal Neurons

Fukui

Kawakami

Honjo

et al. 2012

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummarySeveral lines of evidence demonstrate the relationship between vitamin E deficiency and cognitive dysfunction in rodent models, but little is known about the underlying mechanisms. In this study, we found axonal injury in the hippocampal CA1 region of vitamin E-deficient and normal old mice using immunohistochemical assay. The number of cells in the hippocampal CA1 region of vitamin E-deficient mice and normal old mice was significantly lower than in normal young mice. It is well known that collapsin response mediator protein (CRMP)-2 plays a crucial role in the maintenance of axonal conditions. The expressions of CRMP-2 in the cerebral cortex and hippocampus of vitamin E-deficient mice were significantly lower than both the regions of normal ones. In normal old mice, the expression of CRMP-2 in the cerebral cortex was significantly lower than in the normal ones. In addition, the appearance of microtubule-associated protein (MAP)-light chain 3 (LC3), a major index of autophagy, was higher in the cerebral cortex and hippocampus of vitamin E-deficient mice than in normal young and old mice. These results indicate that axonal degeneration is induced in living tissues, but not cultured cells, and that changes in CRMP-2 and MAP-LC3 may underlie vitamin E-deficiency-related axonal degeneration.

show abstract

“…In a study published in "International Journal of Clinical and Experimental Pathology" found that L-arginine could affect the origination and development of Alzheimer disease. Yet there are still a lot of questions that should be answered about using Arginine as a supplement in diseases that affect brain structures [55].…”

Section: Argininementioning

confidence: 99%

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

Yotova¹

2015

IJNFS

View full text Add to dashboard Cite

Email address: M_jotova@mu-pleven Abstract: Caffeine, Taurine and Arginine are one of the most widely used supplements from people of all ages. There are lot of controversial information about their proper use and effects and side effects. Our goal is to determine the reasonable boundaries of using these supplements in healthy people and more important in people with socially important diseases like high blood pressure, diabetes and dementia.

show abstract

Aging affects l-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels

Cited by 34 publications

References 55 publications

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

Vitamin E Deficiency Induces Axonal Degeneration in Mouse Hippocampal Neurons

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

Contact Info

Product

Resources

About