Aging and chronic disease as independent causative factors for death and a programmed onset for chronic disease

Liu, Hui

doi:10.1016/j.archger.2014.11.002

Cited by 17 publications

(19 citation statements)

References 12 publications

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“…Sakit, as disease, is infective or not, chronic or not, recurring like cough and colds, etc. Chronic diseases, such as arthritis, high blood pressure, stoke, cataract, diabetes, etc., can lead to inactivity for life [65]. Arthritis and rheumatism, cough and colds, indigestion, emphysema, poor eyesight, poor hearing, high blood and hypertension, kidney stones, gallstones, osteoporosis, etc., constitute a constellation of complains about an aging body.…”

Section: Change and Agencymentioning

confidence: 99%

Thinking about Aging: Experience, Identity and Meaning among an Elderly Population in the Philippines

Esteban¹

2015

AAR

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The paper aims to know the idioms that the elderly use to describe and make sense of their experience of aging. It is based on ethnographic data gathered through the in-depth interview of 30 normal and community dwelling elderly in Marikina City, Metro Manila, Philippines in 2012-2013. The participants were chosen through compulsive sampling from the registry of 1385 senior citizens screened free from dementia. Their age ranged from 60 to 90 years, regardless of social class, gender, ethnicity, religion and other indices of difference. The interviews were transcribed, verbatim, and coded for the idioms, their meanings and contexts in which the elderly used them. The elderly communicate in idioms, which maybe basic to denote identity that obtains from aging or secondary in that they develop from the basic ones and help define identity further. The idioms relate to either continuity or discontinuity theory of aging or help rationalize what it means to be human and elderly.

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Section: Change and Agencymentioning

confidence: 99%

Thinking about Aging: Experience, Identity and Meaning among an Elderly Population in the Philippines

Esteban¹

2015

AAR

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“…e model was based on the fact that the multigene effect constitutes the normal distribution of the effects of genes (strong or weak) in the population, and its theoretical basis is solid and reliable. In terms of diseases, especially tumors or chronic diseases, their occurrence is greatly affected by nongenetic factors such as aging [15][16][17]. Furthermore, the incidence is low and family data are difficult to obtain [18].…”

Section: Discussionmentioning

confidence: 99%

Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance

Liu

2020

Computational and Mathematical Methods in Medicine

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Objective. To establish a model for estimating genetic risk using known and unknown family data. Methods. Four simulated datasets were generated for four paternal and maternal chromosomes. The simulated data for children were generated from the parental data according to the Mendelian law. The correlation coefficient between the children’s and paternal data was calculated, and 2R was defined as the heredity index for continuous data (HIC). The simulated continuous data were transformed into binary data according to the gene accumulation threshold (incidence); the incidences of children in the parental no-disease group and the disease onset group were obtained; the correlation coefficient (R) was calculated as expected R (Re). The ratio of observed R (Ro) and Re was defined as the Heredity index for binary data (HIB). Results. Different actual pedigree data (lunula and holding a hammer in the right or left hand) were successfully used to verify the accuracy of the model. The genetic risk was estimated according to the incidence in a population using a lookup table. Conclusion. Our findings indicate the reliability of the model based on the fact that the multigene effect constitutes the normal distribution. Thus, this model can be used for comprehensive analysis of the influence of genetic and nongenetic factors on the genetic phenotype and to estimate genetic risk using known and unknown family data.

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“…The incidence and development of chronic diseases are related to various factors, such as aging, genetics, smoking, overweight, and hyperlipidemia [1][2][3][4]; however, these risk factors are not necessarily associated with any particular disease. It is well known that incidence of chronic diseases increases with age, therefore, aging is believed to be the most significant risk factor for developing chronic diseases [5][6][7]. We believe that reliability of these risk factors with lack of aging as an integer is questionable due to our previous study which found that the role of aging was over 80% in most chronic diseases [7].…”

Section: Introductionmentioning

confidence: 93%

“…It is well known that incidence of chronic diseases increases with age, therefore, aging is believed to be the most significant risk factor for developing chronic diseases [5][6][7]. We believe that reliability of these risk factors with lack of aging as an integer is questionable due to our previous study which found that the role of aging was over 80% in most chronic diseases [7]. It is necessary to evaluate the characteristics of chronic diseases using 2 properties: (1) aging and (2) other risk factors excluding aging.…”

Section: Introductionmentioning

confidence: 99%

Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease

Gao

Liu²

2020

aoms

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The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and methods: The index of organic mild impairment, which is similar to the frailty index, was determined with imaging parameters as organic BA. The functional BA was calculated with the following formula: Functional BA = [systolic-diastolic BP (mm Hg)] × waist circumference 2 (m) × height 0.5 (m)/weight (kg). A total of 1047 subjects undergoing routine health examination were randomly selected to establish a system with organic BA on the X-axis, functional BA on the Y-axis; organic and functional BAs from chronological age with 60 years as a center point of the coordinate system. A total of 85 patients with type 2 diabetes controls were recruited to verify the system. Results: Organic and functional BA contributed to chronological age almost equally. Both organic and functional BA increased with chronological age in the two-dimensional system for a random population. There were significant difference for distribution between diabetes and control groups in two-dimensional system (p < 0.05). That both more in quadrant II and lesser in quadrant IV for diabetes were suggested that diabetes was more sensitive to other risk factors than aging. Conclusions: Combination of the two BAs could precisely recognized aging and other risk factors according to locations of the disease in each quadrant and quantitatively assessed status of nature aging and disease-related aging in a individual.

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Aging and chronic disease as independent causative factors for death and a programmed onset for chronic disease

Cited by 17 publications

References 12 publications

Thinking about Aging: Experience, Identity and Meaning among an Elderly Population in the Philippines

Thinking about Aging: Experience, Identity and Meaning among an Elderly Population in the Philippines

Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance

Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease

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