Aging and circadian rhythms: general trends

Pandi-Perumal, Seithikurippu R.; Spence, D. Warren; Sharma, Vijay Kumar

doi:10.1017/cbo9780511770661.004

Cited by 6 publications

(7 citation statements)

References 199 publications

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“…With advancing age, there are significant changes to sleep and the circadian system, such as higher fragmentation of sleep and increased awakenings, with a decrease in percentage of total sleep time spent in the deeper stages of slow‐wave sleep (SWS; Floyd, ). Furthermore, in many individuals circadian phase advance is common, which can result in premature waking or a reduction in the total duration of sleep (Pandi‐Perumal et al ., ). It is thus not surprising that self‐reported sleep difficulties occur in about 50–60% of adults aged 60 years and over (Almeida and Pfaff, ).…”

Section: Introductionmentioning

confidence: 97%

Napping in older people ‘at risk’ of dementia: relationships with depression, cognition, medical burden and sleep quality

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Rogers

et al. 2015

Journal of Sleep Research

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SUMMARYSleep disturbance is prevalent in older adults, particularly so in those at a greater risk of dementia. However, so far the clinical, medical and neuropsychological correlates of daytime sleep have not been examined. The aims of this study were to investigate the characteristics and effects of napping using actigraphy in older people, particularly in those 'at risk' of dementia. The study used actigraphy and sleep diaries to measure napping habits in 133 older adults 'at risk' of dementia (mean age = 65.5 years, SD = 8.4 years), who also underwent comprehensive medical, psychiatric and neuropsychological assessment. When defined by actigraphy, napping was present in 83.5% (111/133) of participants; however, duration and timing varied significantly among subjects. Nappers had significantly greater medical burden and body mass index, and higher rates of mild cognitive impairment. Longer and more frequent naps were associated with poorer cognitive functioning, as well as higher levels of depressive symptoms, while the timing of naps was associated with poorer nocturnal sleep quality (i.e. sleep latency and wake after sleep onset). This study highlights that in older adults 'at risk' of dementia, napping is associated with underlying neurobiological changes such as depression and cognition. Napping characteristics should be more routinely monitored in older individuals to elucidate their relationship with psychological and cognitive outcomes.

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Section: Introductionmentioning

confidence: 97%

Napping in older people ‘at risk’ of dementia: relationships with depression, cognition, medical burden and sleep quality

Cross

Terpening

Rogers

et al. 2015

Journal of Sleep Research

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“…Available data in both animals and humans demonstrate an age-related phase advance of endogenous rhythms (Dijk et al, 2000;Monk, 2005;Pandi-Perumal et al, 2010), which is consistent with earlier sleep and wake times commonly reported by older adults Czeisler et al, 1992;Monk, Reynolds, Buysse, & Hoch, 1991). In experiments using a constant routine protocol which minimizes the masking effects of the sleep-wake cycle on endogenous rhythms, the nadir of core body temperature and crest of melatonin rhythm were found to occur significantly earlier in older adults (Dijk et al, 2000).…”

supporting

confidence: 77%

“…This evidence is presented to illustrate how age-related changes in the circadian system leave elders vulnerable to disturbance in the face of environmental challenge. More thorough discussions of age-related changes to the circadian timing system are available elsewhere (Monk, 2005;Pandi-Perumal, Spence, & Sharma, 2010;.…”

Section: Circadian Rhythms and Agingmentioning

confidence: 99%

“…Several age-related changes to the circadian timing system have been documented including difficulty tolerating phase shifts, endogenous and overt rhythm advancement, reduced rhythm amplitude, loss of entrainment stability and loss of synchrony between oscillatory processes (Pandi-Perumal et al, 2010). A shortened intrinsic period has been implicated in age-related phase advances and sleep fragmentation, but there is mounting evidence to refute this hypothesis.…”

mentioning

confidence: 99%

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Behavioral rhythm, sleep, and mood disturbances in newly admitted nursing home residents.

Kostiwa¹

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“…Sleep and chronobiological functioning undergo numerous changes with advancing age. These include loss of entrainment stability and responsiveness to zeitgebers , changes in clock period and stability, and alterations in clock-regulated processes (Pandi-Perumal et al, 2010 ), the most salient of which are reductions in the amplitude of melatonin secretion (Cardinali and Karasek, 2010 ). These changes, which are often accompanied by a desynchronization of the body's intrinsic rhythms, can produce considerable morbidity and distress among the aged.…”

mentioning

confidence: 99%