Great challenges to sleep medicine: problems and paradigms

Pandi-Perumal, Seithikurippu R.; Spence, Des; Brown, Gregory M.; Thorpy, Michael J.

doi:10.3389/fneur.2010.00007

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…However, the superiority of synthetic drugs over the natural, particularly well-tolerable hormone melatonin may be questioned. Although ramelteon seems to exert somewhat stronger effects than melatonin in extending sleep time, its relative improvement in sleep maintenance in insomniacs is still rather moderate 26 . With regard to the much higher recommended doses of the synthetic drugs, compared to melatonin, the therapeutic gain may be questioned, since melatonin is already effective at rather low doses in promoting sleep onset 75 .…”

Section: Treatment Of Menopausal Insomnia Using Melatoninmentioning

confidence: 97%

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Sleep, Melatonin, and the Menopausal Transition: What Are the Links?

Jehan¹,

Jean-Louis²,

Zizi³

et al. 2017

Sleep Sci

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The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri- and postmenopausal women often complain of difficulties initiating and/or maintaining sleep, with frequent nocturnal and early morning awakenings. In this review we discuss the pathophysiology of melatonin function as it relates to sleep disorders in menopausal women, highlighting the potential use of exogenous melatonin during the menopausal transition and beyond.

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Section: Treatment Of Menopausal Insomnia Using Melatoninmentioning

confidence: 97%

“…Aging is typically associated with both impairments of the circadian system and decreases in melatonin secretion 5,[25][26][27][28][29] . As outlined in these reviews, the changes are interindividually highly variable.…”

Section: Human Aging and Melatonin Secretionmentioning

confidence: 99%

Sleep, Melatonin, and the Menopausal Transition: What Are the Links?

Jehan¹,

Jean-Louis²,

Zizi³

et al. 2017

Sleep Sci

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“…A current review of the literature regarding ethics and sleep treatment yielded few articles addressing clinical practice issues. Several articles examined informed consent for medical treatment (e.g., continuous positive airway pressure; prescription hypnotics) in adults (Pandi-Perumal, Spence, Brown, & Thorpy, 2010; Wickwire, 2014). To our knowledge, there is no previously published literature specifically focused on ethical considerations related to pediatric behavioral sleep intervention.…”

Section: Framing the Ethical Considerations Regarding Extinction-base...mentioning

confidence: 99%

Behavioral treatment of pediatric sleep disturbance: Ethical considerations for pediatric psychology practice.

Byars¹,

Simon²

2016

Clinical Practice in Pediatric Psychology

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Delayed sleep onset and problematic night wakings are common during the infant and toddler years. Such sleep disturbances typically develop as the result of learned associations with specific cues needed for sleep initiation and/or maintenance that are not consistently available at bedtime or immediately available to the child after night wakings (e.g., rocking, feeding, being held). Effective empirically supported behavioral treatments for these common sleep problems exist. Despite the research evidence supporting the effectiveness of these behavioral treatments, widespread dissemination of unsubstantiated concerns about the appropriateness and theorized negative impact of behavioral sleep treatments persists. Some researchers have even raised concerns about the ethics of health providers providing behavioral sleep treatments, particularly extinction-based treatments. As a result, providers of pediatric behavioral sleep services routinely encounter parents who raise concerns about the use of extinction-based behavioral treatments. Unwarranted parental concerns may prevent some families from seeking services that could lead to positive health outcomes. This article discusses important ethical considerations for pediatric psychologists who provide behavioral sleep medicine services. Recommendations for evidence-based clinical practice are made considering American Psychological Association Ethical Principles of Psychologists and Code of Conduct, American Academy of Pediatrics guidelines for safe sleep practices, and current research on behavioral sleep treatment outcomes.

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“…Although the function of sleep is still not fully understood, there is ample evidence to indicate that sleep is vital for human functioning. 1,2 Life is full of unexpected events that cause people to experience the occasional sleepless night or have transient insomnia symptoms; however, when symptoms persist over a prolonged period they may make a serious impact on an individual's functioning and quality of life (QoL). 3 Insomnia is a common complaint in the general population across most developed countries, with prevalence rates varying from 19% in France, 27.6% in the United Kingdom, and 21% in the United States.…”

Section: Introductionmentioning

confidence: 99%

Sleep…Naturally: A Review of the Efficacy of Herbal Remedies for Managing Insomnia

Antoniades¹,

JonesKay²,

HassedCraig³

et al. 2012

Alternative and Complementary Therapies

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Aim: The aim of this article is to review identified literature on the effectiveness of commonly used herbal remedies for insomnia. Methods: A search of the internet and electronic databases was conducted. Results: Fourteen herbal remedies were identified from the initial web search; however, only six of the fourteen websites returned any literature when combining the search terms with insomnia. One hundred and fifty-six articles were found, and 18 articles matched the inclusion criteria, while 138 articles were excluded. The literature found and reviewed by the current authors had investigated valerian (Valeriana officinalis) alone or in combination with other herbs, hops (Humulus lupulus), kavakava (Piper methysticum), chamomile (Matricaria recutita), and St. John's wort (Hypericum perforatum). Discussion: Few studies specifically investigate the effect of commonly used herbal remedies on insomnia. Valerian alone, or in combination with other compounds, has received some research attention, whereas other herbal remedies, such as St. John's wort, chamomile, and kava-kava have received very little attention. Conclusion: It is surprising that herbal remedies used for insomnia and sold as over-the-counter remedies have received very little research attention. Considering the rise in the use of complementary and alternative medications, it would seem appropriate that such preparations were assessed scientifically for therapeutic potential and safety. Additional research is required to provide evidence for the effectiveness and safety of these popular herbal remedies as therapeutic agents for treating insomnia symptoms.

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Great challenges to sleep medicine: problems and paradigms

Cited by 7 publications

References 28 publications

Sleep, Melatonin, and the Menopausal Transition: What Are the Links?

Sleep, Melatonin, and the Menopausal Transition: What Are the Links?

Behavioral treatment of pediatric sleep disturbance: Ethical considerations for pediatric psychology practice.

Sleep…Naturally: A Review of the Efficacy of Herbal Remedies for Managing Insomnia

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