Aging changes in the optic tectum of the guppy Poecilia (lebistes) reticulatus

Woodhead, Avril D.; Pond, Virginia

doi:10.1016/0531-5565(84)90003-2

Cited by 15 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, an increase in percent pyknotic cells is observed in the OT, a region important for vision and spatial orientation. Woodhead and Pond (1984) described neuronal loss in the optic tectum during aging of the teleostean fish, Poecilia reticulatus. The loss of escape behavior in spawning salmon (Dickhoff, 1989) could relate to OT malfunctions.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Timing of neurodegeneration and beta‐amyloid (Aβ) peptide deposition in the brain of aging kokanee salmon

2002

View full text Add to dashboard Cite

Brains of kokanee salmon (Oncorhynchus nerka kennerlyi) in one of four reproductive stages (sexually immature, maturing, sexually mature, and spawning) were stained with cresyl violet and silver stain to visualize neurodegeneration. These reproductive stages correlate with increasing somatic aging of kokanee salmon, which die after spawning. Twenty-four regions of each brain were examined. Brains of sexually immature fish exhibited low levels of neurodegeneration, whereas neurodegeneration was more marked in maturing fish and greatest in spawning fish. Neurodegeneration was present in specific regions of the telencephalon, diencephalon, mesencephalon, and rhombencephalon. Pyknotic neurons were observed in all regions previously reported to be immunopositive for A beta. Regions that did not exhibit neurodegeneration during aging included the magnocellular vestibular nucleus, the nucleus lateralis tuberis of the hypothalamus, and Purkinje cells of the cerebellum, all of which also lack A beta; perhaps these regions are neuroprotected. In 14 of 16 brain areas for which data were available on both the increase in A beta deposition and pyknosis, neurodegeneration preceded or appeared more or less simultaneously with A beta production, whereas in only two regions did A beta deposition precede neurodegeneration. This information supports the hypothesis that A beta deposition is a downstream product of neurodegeneration in most brain regions. Other conclusions are that the degree of neurodegeneration varies among brain regions, neurodegeneration begins in maturing fish and peaks in spawning fish, the timing of neurodegeneration varies among brain regions, and some regions do not exhibit accelerated neurodegeneration during aging.

show abstract

Section: Discussionmentioning

confidence: 98%

“…However, it is not clear if neurodegeneration is positively correlated with this amyloidosis in the senescent salmon brain. There is little information on neurodegeneration during aging of teleostean fishes (except see Woodhead and Pond, 1984).…”

Section: Introductionmentioning

confidence: 98%

Timing of neurodegeneration and beta‐amyloid (Aβ) peptide deposition in the brain of aging kokanee salmon

2002

View full text Add to dashboard Cite

show abstract

“…The development of new model organisms is vital to compensate for the limitations of previous model systems. In the past, several fish species have been adopted as potential ageing model organisms, including medaka ( Ding et al, 2010 ; Egami and Eto, 1973 ; Gopalakrishnan et al, 2013 ), guppies ( Reznick et al, 2006 ; Woodhead and Pond, 1984 ; Woodhead et al, 1983 ) and both American as well as African killifish ( Liu and Walford, 1966 ; Markofsky and Milstoc, 1979a , b ). As highlighted in this article, the turquoise killifish has emerged as a promising new model organism for vertebrate ageing because it uniquely combines a short lifespan and life cycle with vertebrate-specific features that are missing from the currently used non-vertebrate model organisms.…”

Section: Looking Forward: Potential Applications and Limitations Of Kmentioning

confidence: 99%

The short-lived African turquoise killifish: an emerging experimental model for ageing

Kim

Nam

Valenzano

2016

Disease Models &Amp; Mechanisms

113

View full text Add to dashboard Cite

Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model.

show abstract

“…In general, there is no overall loss of neurons in the brains of humans [34] or fish [35] , and the brain structure is largely preserved during aging. However, a detailed stereological analysis revealed neuronal loss in specific brain areas [36] .…”

Section: Cellular Agingmentioning

confidence: 99%

Oxidation and Cognitive Impairment in the Aging Zebrafish

et al. 2015

View full text Add to dashboard Cite

Background: The zebrafish has become an established model organism in aging research giving insight into general aging processes in vertebrates. Oxidative stress in aging may damage proteins and lipids in brain cells. Enhanced levels of oxidized macromolecules exert neurotoxic effects that could lead to disturbances in neuronal functioning and cognitive skills. Objective: This study aims to investigate a possible relation between oxidative stress and learning deficits during aging in zebrafish. Methods: We tested zebrafish of different ages in a color discrimination paradigm for associative learning and in a hole board task for spatial learning abilities. Afterwards, we determined the levels of oxidized lipids and proteins as well as the amount of lipofuscin in the learning-relevant brain regions of animals of the same age. Results: While young zebrafish at the age of 1 year successfully completed both learning tasks, cognitive abilities were significantly impaired in older animals. Learning deficits occurred at the age of 2 years, where we also detected significantly increased levels of lipofuscin and oxidized proteins in the zebrafish medial and lateral pallial areas of the dorsal telencephalon. Conclusion: These data suggest that enhanced oxidative stress may contribute to behavioral and cognitive impairments in the aging zebrafish.

show abstract

Aging changes in the optic tectum of the guppy Poecilia (lebistes) reticulatus

Cited by 15 publications

References 23 publications

Timing of neurodegeneration and beta‐amyloid (Aβ) peptide deposition in the brain of aging kokanee salmon

Timing of neurodegeneration and beta‐amyloid (Aβ) peptide deposition in the brain of aging kokanee salmon

The short-lived African turquoise killifish: an emerging experimental model for ageing

Oxidation and Cognitive Impairment in the Aging Zebrafish

Contact Info

Product

Resources

About