Aging lowers PEX5 levels in cortical neurons in male and female mouse brains

Abstract

Chapter 1: Introduction This chapter is based upon "Peroxisomal dysfunction in neurological diseases and brain aging", courtesy of Frontiers in Cellular Neuroscience, © Uzor, McCullough, and Tsvetkov. 2020. Chapter 4: Aging lowers PEX5 levels in cortical neurons in male and female mouse brains This chapter is based upon "Aging lowers PEX5 levels in cortical neurons in male and female mouse brains," a first-author publication accepted by Molecular Cellular Neuroscience, August 2020.

Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis

“…While much of the focus on understanding the role of peroxisomes in human disease is focused on the rare genetic peroxisome biogenesis disorders, there is increasing interest in the impact of peroxisome dysfunction on nonhereditary and age-related diseases. In model organisms such as C. elegans, fruit flies, and mice, PEX protein levels decline with age [248][249][250]. Recent studies looking at the induced loss of PEX1 or overexpression of PEX5 mutants incapable of protein extraction [17,251] are starting to provide insight into the impact of peroxisome stress on otherwise healthy cells.…”

Alterations in Peroxisomal-Mitochondrial Interplay in Skeletal Muscle Accelerates Muscle Dysfunction

“…The contribution of these lipids to the pathogenesis of age-related muscle disease is highlighted by a study showing that inhibiting ceramide synthesis preserves muscle function during aging 77 , and maintains muscle mass in Colon-26 carcinoma tumor-bearing mice 78 . Moreover, Pex5 transcript and protein levels are reduced in the cortical neurons of aged mice 79 . Similarly, in C. elegans, levels of PRX-5 (Pex5 in mice and humans), and nearly 30 other peroxisomal proteins involved in peroxisomal protein import and function are reduced with aging.…”