Aging of Bioactive Glass-Based Foams: Effects on Structure, Properties, and Bioactivity

Menci, P. F.; Mari, A.; Charbonneau, Cindy; Lefebvre, Louis‐Philippe; Nardo, Luigi De

doi:10.3390/ma12091485

Cited by 12 publications

(17 citation statements)

References 23 publications

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“…160 The interconnected porous structure of BGs resembles trabecular bone and provides a temporary template for cell regeneration. 161 However, it may be a limitation in the manufacture of a bone repair scaffold with sufficient strength due to the slow conversion of BGs to HA in vivo and the tendency of BGs to crystallize during heat treatment. Additionally, the degradation of pure silicate BGs is slow, and the conversion of BGs to HA in vivo is difficult to control.…”

Section: Treating Bone Defects Without Infectionmentioning

confidence: 99%

Application of bioactive metal ions in the treatment of bone defects

Cui

et al. 2022

J. Mater. Chem. B

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Section: Treating Bone Defects Without Infectionmentioning

confidence: 99%

Application of bioactive metal ions in the treatment of bone defects

Cui

et al. 2022

J. Mater. Chem. B

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“…Tissue engineering has become a rapidly growing field, driven by the need for correcting orthopedic, dental, and maxillofacial problems. In particular, it reconstructs lost tissue and critical defects caused by disease or accidents 1–7 . This study, bio‐cellular glass–ceramic composites and their ceramic derivatives are composed of a matrix phase (waste glass powder) and a dispersed phase (calcium phosphate such as (Ca 3 PO 4 ) 2, CaHPO 4 , Ca 10 (PO 4 ) 6 (OH) 2 from eggshell powder).…”

Section: Introductionmentioning

confidence: 99%

“…They are also nontoxic, lightweight, react with bodily fluids, and connect to soft or hard bone. Bone healing is the most common purpose of tissue implants in orthopedic and craniofacial surgery 1–5 . Cartilage is the support material of soft tissues such as ear, nose, and tendons 1–5 .…”

Section: Introductionmentioning

confidence: 99%

“…Bio-glass foams and bio-glass ceramic foams have been widely applied as alternative biomaterials in medical and dental applications. [1][2][3][4][5] As scaffold materials for bone, cartilage, joints, tendons, ligaments, and muscles, they offer distinct advantages such as biocompatibility, endurance, high-mechanical properties (hardness, compressive strength, and fracture toughness), and a porous threedimensional (3D) network. 1,3 They are also nontoxic, lightweight, react with bodily fluids, and connect to soft or hard bone.…”

Section: Introductionmentioning

confidence: 99%

“…Bone healing is the most common purpose of tissue implants in orthopedic and craniofacial surgery. [1][2][3][4][5] Cartilage is the support material of soft tissues such as ear, nose, and tendons. [1][2][3][4][5] Bio-glasses and their ceramic foams are bio-composite materials that migrate within the aqueous medium of the body.…”

Section: Introductionmentioning

confidence: 99%

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Bio‐cellular glass–ceramic composite with embedded calcium phosphate from eggshell for alternative biomaterials in medical and dental applications

Kongpaopong

Ratchatawatanapipat

Tangboriboon

2021

J of Applied Polymer Sci

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Green biomaterial foams with nontoxicity, low weight, low density, and high‐compressive strength, which can be easily manufactured at low cost, are urgently sought. When implanted as a scaffold, bio‐cellular glass–ceramic composite has potential for bone bonding, connective tissue growth, and reconstruction of lost tissue. The present study investigates the physical‐thermo‐mechanical properties of bio‐cellular glass–ceramic composite supplemented with calcium phosphate from eggshell powder (0, 1, 3, or 5 wt%) and sodium‐silicate binder. The composite materials were prepared by hand pressing and fired at 800 or 900°C for 1 h. The composites containing 1 and 3 wt% calcium phosphate from eggshell powder and fired at 800°C achieved suitable porosity (74–79%), pore size (20–800 μm), bulk density (0.57–0.70 g/cm3), true density (0.98–1.06 g/cm3), water absorption (10.31–21.41%), compressive strength (2.71–3.23 MPa), and thermal expansion coefficient ([5.95–5.98] × 10−6°C−1) for practical applications. The obtained bio‐cellular glass–ceramic composite is an alternative biomaterial for biomedical and dental applications.

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Injectable cell‐laden hybrid bioactive scaffold containing bioactive glass microspheres

Rahimnejad

Charbonneau

et al. 2023

J Biomedical Materials Res

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The rising incidence of bone disorders has resulted in the need for minimally invasive therapies to meet this demand. Injectable bioactive filler, alone or with cells, could be applied in a minimally invasive manner to fulfill irregular cavities in non‐load bearing sites, which do not require high mechanical properties. Thermosensitive chitosan hydrogels that transition from a liquid to a mechanically stable solid at body temperature provide interesting features as in‐situ injectable cytocompatible biomaterials, but they are not osteoconductive. Osteoconductivity can be applied in combination with bioactive ceramics e.g., 45S5‐Bioglass® (BG). However, BG addition in chitosan hydrogels results in pH elevation, due to rapid ions release, which adversely affects gel formation, mechanical properties, and cytocompatibility. To address this, we created hybrid hydrogels, where BG is concentrated in chitosan‐based microbeads, incorporated in in‐situ gelling chitosan hydrogels. We then compared the hybrid hydrogels' properties to chitosan hydrogels with homogenously distributed BG. By varying the stirred emulsification process, BG percentage, and CH formulation, we could tune the microbeads' properties. Incorporation of BG microbeads drastically improved the hydrogel's compressive modulus in comparison to homogeneously distributed BG. It also strongly increased the survival and metabolic activities of encapsulated cells. Calcium/phosphate increase on BG microbeads suggests hydroxyapatite formation. The small diameter of microbeads allows minimally invasive injection through small needles. The feasibility of freezing and thawing microbeads provides the possibility of long‐term storage for potential clinical applications. These data indicate that this hybrid hydrogel forms a promising injectable cell‐laden bioactive biomaterial for the treatment of unloaded bone defects.

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Aging of Bioactive Glass-Based Foams: Effects on Structure, Properties, and Bioactivity

Cited by 12 publications

References 23 publications

Application of bioactive metal ions in the treatment of bone defects

Application of bioactive metal ions in the treatment of bone defects

Bio‐cellular glass–ceramic composite with embedded calcium phosphate from eggshell for alternative biomaterials in medical and dental applications

Injectable cell‐laden hybrid bioactive scaffold containing bioactive glass microspheres

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