Aging of the progenitor cells that initiate prostate cancer

Freeland, Jack; Crowell, Preston D.; Giafaglione, Jenna M.; Boutros, Paul C.; Goldstein, Andrew S.

doi:10.1016/j.canlet.2021.05.014

Cited by 25 publications

(23 citation statements)

References 117 publications

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“…It is noted PSAD was fluctuating around mean PSAD of 0.11 in majority of the age groups (Figure 3). There are several studies confirming a correlation between prostate volumes and ageing [6]. In this study, the mean prostate volume of Sri Lankan men is gradually increasing with age and this is comparable with the data published in other studies.…”

Section: Figure 1 Variations Of Mean Prostate Volume With Different A...supporting

confidence: 91%

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Balagobi¹,

JP²,

Chandrasekera³

et al. 2022

GSC Adv. Res. Rev.

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Purpose: Benign Prostatic Hyperplasia (BPH) is an important cause of morbidity for ageing men worldwide. However, the available study is limited on the natural history of BPH and dynamics of Prostate-Specific Antigen (PSA) in Sri Lankan population. This study aimed to assess the relationship between serums Prostate Specific Antigen (PSA), prostate volume (PV), and PSA density (PSAD) and to evaluate variations of above parameters with aging and to assess the mean prostate volume of Sri Lankan men with Benign Prostatic Hyperplasia (BPH). Material and methods: This was a retrospective study, men diagnosed with Benign Prostatic Hyperplasia from January 2009 was evaluated. This study was approved by the Ethics Review Committee of Colombo South Teaching Hospital and the patient informed written consent was received. Those with UTI, PSA >10ng/dl and suspicious prostate in digital rectal examination (DRE) were excluded from the study. Data were statistically analyzed to determine the relationship of PSA, PV, PSAD and variations with age groups. Results: This study recruited a total number of 562 men, clustered into 5 age groups and their mean Prostate Volume (PV) was 42.9 (12.56SD). The median PSA was 2.5ng/dl with an inter quartile range of 0.37. The mean PSA density (PSA/PV) was 0.11 (0.023SD). The tendency towards increase in PSA and prostate volume with increasing age showed statistical significance (P<0.05). PSA density was not changed much between different age group except 51-60 age group. It is noted PSAD was fluctuating around mean PSAD of 0.11 in majority of the age groups. Conclusion: PV and PSA increase with age. Mean PV is relatively small compare to blacks and Caucasians. .PSA density in Sri Lankan men is comparable to published data in other countries and could be used as a surrogate marker to evaluate the prostate and for therapeutic decision making.

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Section: Figure 1 Variations Of Mean Prostate Volume With Different A...supporting

confidence: 91%

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Balagobi¹,

JP²,

Chandrasekera³

et al. 2022

GSC Adv. Res. Rev.

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“…We then examine the functional characterization of luminal progenitor cells and their involvement in prostate homeostasis and pathogenesis in mice and, potentially, in humans. Certain aspects of luminal progenitor biology (for example, epithelial lineage hierarchy, development and ageing) outside the scope of this Review are reviewed in detail elsewhere 11,37,38 .…”

Section: ();mentioning

confidence: 99%

“…According to their molecular proximity with LSC med cells, several markers of TROP2 + luminal cells are part of the 15-gene signature of LSC med -like cells (for example, Krt4, Psca, Cyp2f2, Krt19, Anxa3 and Ppp1r1b). Finally, the core phenotypic signature of LSC med -like luminal progenitor cells appeared to persist with age 38,43 , after castration 31,33,35 and in tumours 31,32 , suggesting that their molecular hallmarks can be used to track them in various pathophysiological contexts.…”

Section: ();mentioning

confidence: 99%

Prostate luminal progenitor cells: from mouse to human, from health to disease

et al. 2022

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Stem and progenitor cells of the adult prostate epithelium have historically been believed to reside mainly or exclusively within the basal cell compartment and to possess basal-like phenotypic characteristics. Within the past decade, evidence of the existence of luminal epithelial cells exhibiting stem/progenitor properties has been obtained by lineage tracing and by functional characterization of sorted luminal-like cells. In 2020, the boom of single-cell transcriptomics led to increasingly exhaustive profiling of putative mouse luminal progenitor cells and, importantly, to the identification of cognate cells in the human prostate. The enrichment of luminal progenitor cells in genetically modified mouse models of prostate inflammation, benign prostate hypertrophy and prostate cancer, and the intrinsic castration tolerance of these cells, suggest their potential role in prostate pathogenesis and in resistance to androgen deprivation therapy. This Review bridges different approaches that have been used in the field to characterize luminal progenitor cells, including the unification of multiple identifiers employed to define these cells (names and markers). It also provides an overview of the intrinsic functional properties of luminal progenitor cells, and addresses their relevance in mouse and human prostate pathophysiology.

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“…1A ) that are frequently double-positive for both CK5 and CK8 (i.e., CK5 + CK8 + ), express high levels of CK19 (CK19 +/hi ), and retain significant proliferative capacity [ 8 – 23 ]. The LPs are also endowed with an enhanced ability to form organoids ex vivo [ 18 , 21 , 23 ] and express high levels of prostate stem cell antigen (PSCA) and low levels of CD38 (i.e., CD38 lo ) [ 22 – 25 ]) ( Fig. 1A ).…”

Section: Introductionmentioning

confidence: 99%

“…Evidence is accumulating that LPs in the luminal cell compartment ( Fig. 1A ) may represent the preferred cellular targets of tumorigenic transformation [ 18 , 20 – 25 ]. The NHP LPs represent < 2% of the CD26 + CD49 lo (or TROP2 + CD49 lo ) luminal cell population, can readily establish organoids containing both luminal and basal cells (i.e., bipotentiality; [ 18 , 21 , 23 ]), and have been phenotyped as PSCA hi CD38 lo [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Understanding and targeting prostate cancer cell heterogeneity and plasticity

Tang¹

2022

Seminars in Cancer Biology

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Aging of the progenitor cells that initiate prostate cancer

Cited by 25 publications

References 117 publications

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Prostate luminal progenitor cells: from mouse to human, from health to disease

Understanding and targeting prostate cancer cell heterogeneity and plasticity

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