Aging Process Of Gold Nanoparticles Synthesized In Situ in Aqueous Solutions of Polyacrylamides

Kutsevol, N.; Chumachenko, V.; Harahuts, Yuliia; Marinin, Andriy

doi:10.1201/9781315365985-10

Cited by 6 publications

(7 citation statements)

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“…Characterization of these nanosystems by UV-vis, dynamic light scattering, SAXS, and TEM was reported in our recent works [ 19 , 20 , 27 – 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…The application of biocompatible water-soluble polymers in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of therapeutic agents [17,18]. Polymers can be an efficient matrix for in situ synthesis of metal NPs preventing their aggregation and allowing regulating the nanoparticle size [19][20][21]. The multifunctionality of polymer molecules with unique chemical and biological properties ensures better delivery and a controlled release of various therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity of Hybrid Noble Metal‐Polymer Composites

Tkachenko

Virych

Myasoedov

et al. 2022

BioMed Research International

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The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.

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“…Characterization of these nanosystems by UV-vis, dynamic light scattering, SAXS, and TEM was reported in our recent works [ 19 , 20 , 27 – 29 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Hybrid Noble Metal‐Polymer Composites

Tkachenko

Virych

Myasoedov

et al. 2022

BioMed Research International

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“…Details of synthesis, identification and analysis of gold nanoparticles have been described in literature. [12][13][14][15][16][17]…”

Section: Synthesis and Characterization Of Polymer/aunps Nanosystemmentioning

confidence: 99%

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Kaleynikova

Ukrainska

Sribna

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Given the urgency of the problem of clinical and experimental pathology of diabetes mellitus (DM) and the reproductive function disorders and their correction, the direction of research was determined in the following way: to establish the functional state of testicular cells and appendages under experimental hyperglycemia, and to assess future prospects for gold nanoparticles for clinical trials. The aims to evaluate the effect of five times treatment with gold nanocomposites (gold nanoparticles (AuNPs) in the polymer matrix D-g-PAA(PE) on male reproductive function under conditions of experimental hyperglycemia.Methods: Experiments (two series) have been conducted on 120 (60 males and 60 females) Albino white laboratory mice (weighing 25-30 gm). Experimental hyperglycemia, a model of type 2 diabetes mellitus (DM2) was reproduced by administration of nicotinamide and streptozotocin (internally peritoneally). The treatment of substances was carried out in the following way: D-g-PAA (PE) (10.00 mg/kg), D-g-PAA (PE)/AuNPs (9.78 mg/kg) in the tail vein, in 0.3 ml, once a day, five times, 2 weeks after EG induction once a day, five times.Results: it was established for the first time that there is disorder of male reproductive function under conditions of experimental hyperglycemia and five-fold treatment of gold nanocomposites (D-g-PAA(PE)/AuNPs, namely an increase in the number of abnormal sperm and a decrease in spermatids, as well as an increase in preimplantation mortality of embryos (compared to this value under experimental hyperglycemia).Conclusions: Our new data suggest that treatment with such gold nanocomposites (gold nanoparticles in D-g-PAA (PE) polymer matrix) are not critical for therapeutic use (in photodynamic chemotherapy), even in hyperglycemia when there is diabetes.

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“…29 Polymers can be efficient matrices for the in situ synthesis of metal NPs, preventing their aggregation and allowing the nanoparticle size to be regulated. [30][31][32][33] The multifunctionality of polymer molecules, with unique chemical and biological properties, allows the controlled delivery and release of various therapeutic agents. They are stable in the body, can provide optimal pharmacokinetics and biodistribution, can ensure the protection of healthy tissues, and can support accumulation of drugs in diseased tissue.…”

Section: Introductionmentioning

confidence: 99%