Aging, the gastrointestinal tract, and risk of acid-related disease

Greenwald, David A.

doi:10.1016/j.amjmed.2004.07.019

Cited by 62 publications

(51 citation statements)

References 29 publications

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“…It is estimated that, by the year 2020, about one in six people in the United States will be over 65 yr of age (13). In aging individuals, the widespread chronic use of NSAIDs, which inhibit angiogenesis and gastric injury healing (15,20), and the significantly increased complications, such as gastric mucosal injury caused by NSAIDs (13,31,32), make aging gastropathy an important clinical issue.…”

Section: Discussionmentioning

confidence: 99%

“…In aging individuals, the widespread chronic use of NSAIDs, which inhibit angiogenesis and gastric injury healing (15,20), and the significantly increased complications, such as gastric mucosal injury caused by NSAIDs (13,31,32), make aging gastropathy an important clinical issue. Our study significantly advances and defines a key target and mechanism underlying the impairment of angiogenesis in aging gastropathy, which affects the growing aging population increasingly using aspirin, other NSAIDs, and ulcerogenic drugs.…”

Section: Discussionmentioning

confidence: 99%

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Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy

Ahluwalia

Jones

Tarnawski

2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy

Ahluwalia

Jones

Tarnawski

2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…As population demographics shift towards a more elderly society (WHO, 2002), the incidence of functional gastrointestinal disorders is becoming more prevalent (Greenwald, 2004;Hébuterne, 2003;Pilotto, 2004). This, coupled with an increasing dependence on conventional antibiotics and the emergence of antibiotic-resistant bacteria, poses significant challenges to the effective treatment of gastrointestinal disorders.…”

Section: Introductionmentioning

confidence: 99%

Improving gastric transit, gastrointestinal persistence and therapeutic efficacy of the probiotic strain Bifidobacterium breve UCC2003

et al. 2007

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“…Risk factors for GERD include hiatus hernia, obesity, older age, alcohol and tobacco use, and male sex [4]; in addition, obstructive sleep apnoea may also confer a risk independent of that due to obesity [5]. Given the obesity epidemic and the aging of the population [6] this prevalence figure is likely to increase.…”

Section: Definition and Epidemiologymentioning

confidence: 99%

Gastro-oesophageal reflux disease and non-asthma lung disease

Morehead¹

2009

Eur Respir Rev

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Gastro-oesophageal reflux disease (GERD) is a common disorder in Western countries, and its relationship to airways disorders (e.g. asthma) has been well established. Lung diseases other than asthma have also been associated with GERD, but the nature and scope of this relationship has not been fully defined. Diseases that have been associated with GERD include bronchiolitis syndromes, idiopathic pulmonary fibrosis, scleroderma and nontubercular mycobacterial infection.Diagnostic evaluation centres upon proving both reflux and pulmonary aspiration, which may be accomplished in some cases by lung biopsy. However, in many cases a compatible clinical and radiographic picture coupled with proof of proximal reflux by combined oesophageal probe testing may suffice for a provisional diagnosis and allow institution of anti-reflux measures.Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals. However, acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail.Laparoscopic fundoplication is the procedure of choice for medically refractory GERD with excellent short-term results with respect to respiratory symptoms associated with GERD; however, long-term studies document a significant percentage of patients requiring ongoing acid suppression therapy.

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Aging, the gastrointestinal tract, and risk of acid-related disease

Cited by 62 publications

References 29 publications

Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy

Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy

Improving gastric transit, gastrointestinal persistence and therapeutic efficacy of the probiotic strain Bifidobacterium breve UCC2003

Gastro-oesophageal reflux disease and non-asthma lung disease

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