Aglycones From the Saponin of the Starfish Asterias vulgaris

Findlay, John A.; Agarwal, V. K.

doi:10.1021/np50030a008

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…In addition, the characteristic carbon signals at d C 145.68 (C-9) and 116.48 (C-11) revealed the chol-9(11)-en-23-one skeleton. 11,14,21) 22) and the nuclear Overhauser effect (NOE) correlation between H-3 and H-5 (Fig. 2).…”

Section: Resultsmentioning

confidence: 97%

Asterosaponins Isolated from the Starfish Asterias amurensis

Hwang

Kim²,

Kim

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Resultsmentioning

confidence: 97%

Asterosaponins Isolated from the Starfish Asterias amurensis

Hwang

Kim²,

Kim

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Autotomy (i.e., found in Evasterias troschelii and Pycnopodia helianthoides), spines, modified tube feet called "pedicellaria," camouflage, quick locomotion, and shedding have been reported as physical defenses (Bryan et al 1997;Candia Carnevali and Bonasoro 2001). However, some species such as the sea star Pteraster tesselatus rely to a great extent on their mucus as chemical defense (Nance and Braithwaite Hwang et al (2011Hwang et al ( , 2014 Crude saponin Insecticide and repellant activity Park et al (2009) Asterosides A-D, glycoside B, asterosaponins n.d. Riccio et al (1988) Asterosaponin-4 Cytotoxic Okano et al (1985) Asterosaponin A, A 4 Antitumor Ikegami et al (1973) Asterias vulgaris 13 steroidal compounds n.d. Findlay and Agarwal (1983) Asterias forbesi Forbeside D n.d.…”

Section: Asteroids (Sea Stars)mentioning

confidence: 99%

Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)

Kamyab

Kellermann

Kunzmann

et al. 2019

YOUMARES 9 - The Oceans: Our Research, Our Future

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Echinoderms are a source of a broad range of secondary metabolites with a large variety of bioactive properties. Although pigment and lipid derivatives are the major groups of bioactive compounds found in crinoids and ophiuroids, saponins represent the most abundant and diverse marine natural products (MNPs) in the phylum Echinodermata. This review is for researchers that are interested in MNPs derived from echinoderms, but with a particular focus on the structural diversity and biological function of saponins. Among the echinoderms, these steroidal compounds are mostly known for and structurally most diverse within sea cucumbers. Through compilation of extensive tables, this review provides a reference book, summarizing not only the major chemical classes of well-known secondary metabolites in the phylum Echinodermata but also further focusing on the presence of bioactive saponins in echinoderms in general and within different sea cucumber species in particular. The final compilation aims to correlate the vast structural diversity of saponins with known biological functions. The here presented data revealed that holothurians, holotoxins, cucumariosides, and echinosids are not only the most abundant saponin compounds in various genera of sea cucumbers but that these saponins can also be used as potential chemotaxonomic markers for different sea cucumber species. By studying the structure-function relationships of triterpene glycosides in echinoderms in general, or in particular within holothurians, the vast structural diversity, taxonomic distribution, and bioactivity of the molecules can be deciphered, which provides an opportunity to focus future research efforts on target species that contain MNPs with novel pharmacological activities.

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“…We have recently established (7) the structure 4 for a partial hydrolysis product of the saponin fraction from A. vulgaris. This finding has prompted us to pursue the separation and characterization of the major saponins from this starfish because little is known about their properties or structures despite the abundance of this species in the Bay of Fundy and elsewhere.…”

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confidence: 99%

“…A Perkin-Elmer model 990 gas chromatograph equipped with a flame ionization detector and a 3% OV-101, 60-80 mesh column (2 mm ID X 10') was used at a column temperature of 140°and a helium flow rate of 50 ml/min. Isolation of saponin fraction from a. vulgaris.-This was done as described earlier (7).…”

mentioning

confidence: 99%