Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism

Kim, Ji Woon; Seung, Hana; Kim, Ki Chan; Gonzales, Edson Luck; Oh, Hyun‐A; Yang, Sung Min; Ko, Mee Jung; Han, Seol‐Heui; Banerjee, Sourav; Shin, Chan Young

doi:10.1016/j.neuropharm.2016.09.014

Cited by 83 publications

(62 citation statements)

References 61 publications

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“…VPA model is a well validated model of ASD [25,26]. The model has striking anatomical, pathological and etiological similarities with the human disease [26].…”

Section: Discussionmentioning

confidence: 99%

Negative geotaxis: An early age behavioral hallmark to VPA rat model of autism

Ruhela

Soni

Sarma

et al. 2019

Annals of Neurosciences

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Background: Negative geotaxis (NG) is an important parameter, commonly used in study of different CNS diseases and neurodevelopmental disorders. Neurobehavioural change following brain injury was easily identified by negative geotaxis. Purpose: Although NG is evaluated in the settings of ASD, most of the studies are conducted for short duration (1-3 day) and the overall trend of acquisition of NG is not evaluated. In this context, we wanted to evaluate the trend of acquisition of negative geotaxis as a behavioural marker of autism in Valproic acid (VPA) model of ASD. Methods: Dams in the VPA group were treated with intraperitoneal injections of VPA 600 mg/kg single dose on gestational day 12.5, while the control animals received normal saline of similar volume. Developmental parameters {body weight (PND 8, 10 & 12), body length (PND 4, 5, 6 8, 10), eye opening (PND 10, 12, 14, 15 and 16) and motor development (grid walking test on PND 20)} were monitored. Negative geotaxis test was performed at PND 6, 10, 15 and 17. Results: The results of the present experiments demonstrate that VPA exposed rats exhibited delayed developmental parameters, aberration of the pattern of acquisition of negative geotaxis, enhanced negative geotaxis in early postnatal period (PND 6) and enhanced negative geotaxis in absence of visual clues (PND 17). Conclusion: NG can be a valuable biomarker in early detection of autistic behavior and in absence of visual clues. The abberant negative geotaxis developmental pattern can serve as a marker to detect ASD. Thus NG can serve as an important early age biomarker of ASD. Further studies are required to validate this finding.

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“…VPA model is a well validated model of ASD [25,26]. The model has striking anatomical, pathological and etiological similarities with the human disease [26].…”

Section: Discussionmentioning

confidence: 99%

Negative geotaxis: An early age behavioral hallmark to VPA rat model of autism

Ruhela

Soni

Sarma

et al. 2019

Annals of Neurosciences

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“…In fact, agmatine reduces the accumulation of collagen in diabetic patients (Marx, Trittenwein, Aufrich, Hoeger, andLubec, 1995), plays a protective role against depression in the mouse (Mohseni et al, 20017;Neis et al, 2015), regulates the growth of epithelial cells during the healing of wounds (Gilad and Gilad, 2000) and, lastly, it increases muscle growth while improving physical condition. It is also used in the treatment of autism spectrum disorders in rats (Kim et al, 2017). For these reasons, agmatine is used as a dietary supplement (Gilad and Gilad, 2014).…”

Section: Introductionmentioning

confidence: 99%

Determination of Agmatine Rate by Spectrofluorimetric Method in Alkaline Medium: Optimization and Application on Shrimp.

Kital¹,

Traoré²,

Sarr³

et al. 2019

JCB

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In this work, a spectrofluorimetric method was developed to determine the rate of agmatine (AGM) in shrimp using orthophthalaldehyde (OPA) as derivatization agent. To optimize analytical results, the stoichiometry of the orthophthalaldehyde-agmatine complex (OPA-AGM) was determined. The effects of agitation and temperature on the fluorescence spectra of the complex in alkaline medium (pH 13) were then studied. We obtained in all media satisfactory analytical performances with very low detection limits (DL) ranging from 0.36 to 2.52 ng/mL and a quantification limit (QL) oF 1.62 to 8.40 ng/mL The relative standard deviations (RSD) obtained ranged from 0.08 to 1.5%, which shows the excellent replicability of measurements. In addition, recovery rates found in shrimp extract, between 96.3% and 103.4%, show the accuracy of measurements. Lastly, the interference effects on the determination of agmatine rate with biogenic amines and some metal ions likely to be present in shrimp were studied.

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“…In fact, the various characteristics of the ASD animal models make it difficult to define the etiological mechanism of ASD as a single factor/pathway. For example, NMDA receptor activity, the most widely recognized ASD-related factor to date, varies widely among ASD animal models ( Lee et al, 2015 ; Kim et al, 2017 ). Because ERK is one of the downstream signals of NMDA receptor signaling ( Thomas and Huganir, 2004 ), it is also closely related to our VRK3 -KO study.…”

Section: Discussionmentioning

confidence: 99%