Agnucastoside C, isolated from Moringa oleifera ameliorates thyrotoxicosis and liver abnormalities in female mice

Abstract

Background In the present investigation an attempt was made to evaluate the potential of agnucastoside C (ACC), isolated from the leaves of Moringa oleifera in ameliorating thyrotoxicosis, hepatic lipid peroxidation (LPO) and hyperglycemia in female mice. Methods L-thyroxine (L-T4) at 0.5 mg/kg/d was administered through intra-peritoneal route for 15 consecutive days to induce thyrotoxicosis and then the effects of three different doses (10, 20 and 30 mg/kg body weight) of the isolated ACC for 21 days were investigated on the changes in serum thyroid hormones, insulin, glucose, different lipids; hepatic lipid peroxidation, enzymatic antioxidants such as superoxide dismutase, catalase and glutathione peroxidase, advanced oxidation protein products, reduced glutathione and in lipid peroxides. Results Following the administration of L-T4, serum T3, T4, insulin, glucose levels and the tissue LPO were increased with a decrease in serum thyroid stimulating hormone and antioxidative enzymes. However, administration of the test compound to hyperthyroid animals significantly decreased the levels of thyroid hormones, glucose and lipid peroxidation and normalized the concentration of insulin and tissue antioxidants, suggesting its antithyroid, antihyperglycemic and antiperoxidative potential. The T4-induced adverse effects on liver histology were also abolished. These findings suggest the possible use of the test compound in ameliorating thyrotoxicosis. Conclusion ACC exhibited antithyroidic, antihypoglycemic, antioxidative and insulin normalizing activities.

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

“…Earlier, only its leaf, bark, and pod were reported to be lipid lowering in nature. [28][29][30] Similar type of hypolipidemic effects were also shown by few other flower extracts. [31][32][33] This may be noted that with our results Moringa oleifera plant appears to be helpful in regulating hyperlipidemia with all of its parts.…”

“…From the results of in-vitro antioxidant assays also exhibited the strong antioxidative properties of the test extract, similar to an earlier report on its flower 44 and 2 reports, available on the other parts of Moringa such as leaf and pods. 28,45 These antioxidative properties could be the result of its high contents of phenol and flavonoids. In fact, in our study the total phenolic and flavonoid contents were found to be little higher in the test flower as compared to the results mentioned in some earlier findings.…”

STUDY THE BIOLOGICAL ACTIVITY OF Moringa oleifera AND COFFEE BEANS ON FUNCTIONS AND HISTOLOGY OF LIVER AND KIDNEY IN DIABETIC RATS

“…Administration of Moringa oleifera leaves extract seems to prevent oxidative damage caused by high-fat diet (Sharma et al, 2011) also, can be used to improve the body weight and nearly normalize the thyroid hormones and thyroid stimulating hormone levels indicating the inhibitory activity of MO in thyroid hormone synthesis and/or release in mice (Sunhre, et al ., 2020).…”