The relevance of the study is due to the need to improve the efficiency of personnel management in agriculture at the meso-level, which is caused by the aggravation of the competition, directly related to globalization and the instability of intercountry interaction. In many regions of Russia, there are negative trends in the social and labor sphere of rural areas and a decrease in the share of agricultural enterprises. In these conditions, the priority is the development of import substitution and the active creation and implementation of innovations, which increases the requirements for professional education. The purpose of the article is to assess the impact of vocational education of personnel of agricultural organizations in municipal districts of the region on the annual volume of their production. In preparing the article, we used: monographic method; systemic, sectoral, decomposition and complex methodological approaches; structural-temporal analysis and regression analysis (in kind and in standardized form). A methodology has been developed for analyzing the staffing of agricultural organizations in municipal districts of the region and the impact of vocational education and its components on the volume of production; established an annual decrease in the number of people actually employed in agriculture; by constructing multivariate regression models, the influence of the number in groups of personnel categories on the volume of production of agricultural organizations in current prices was revealed. Models of closeness of connection are given on a natural scale and in standardized form, the latter provide an opportunity to compare the impact of each of the factors on the volume of production. The groups were identified that have direct and inverse relationships with the performance indicator. The obtained quantitative assessments of existing processes (including latent ones) significantly expand information support in the formation of personnel policy both at the meso-level and in organizations. Elimination of the existing negative phenomena will ensure an increase in the efficiency of agriculture as a production system. In the future, the continuation of this study is relevant, in particular, in the sectoral context, both in complex industries and in subsectors.