Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis

Barcellos, Marcio Bezerra; Lasmar, Bernardo Portugal; Lasmar, Ricardo Bassil

doi:10.1007/s00404-015-3892-x

Cited by 11 publications

(14 citation statements)

References 13 publications

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“…However, this has been a specific and accurate method for the detection of deep endometriosis. [25][26][27][28] In conclusion, the combined analysis of the polymorphisms PGR-CYP17A1-CYP19A1 suggests a gene-gene interaction in the susceptibility to endometriosis. The results may contribute to the identification of genetic biomarkers that are able to help in disease diagnosis and/or prognosis, as well as in the identification of possible molecular targets for individualized treatments.…”

Section: Discussionmentioning

confidence: 82%

Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis

Cardoso

Machado

Ferrari

et al. 2017

Rev Bras Ginecol Obstet

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Purpose To evaluate the magnitude of the association of the polymorphisms of the genes PGR, CYP17A1 and CYP19A1 in the development of endometriosis. Methods This is a retrospective case-control study involving 161 women with endometriosis (cases) and 179 controls. The polymorphisms were genotyped by real-time polymerase chain reaction using the TaqMan system. The association of the polymorphisms with endometriosis was evaluated using the multivariate logistic regression. Results The endometriosis patients were significantly younger than the controls (36.0 AE 7.3 versus 38.0 AE 8.5 respectively, p ¼ 0.023), and they had a lower body mass index (26.3 AE 4.8 versus 27.9 AE 5.7 respectively, p ¼ 0.006), higher average duration of the menstrual flow (7.4 AE 4.9 versus 6.1 AE 4.4 days respectively, p ¼ 0.03), and lower average time intervals between menstrual periods (25.2 AE 9.6 versus 27.5 AE 11.1 days respectively, p ¼ 0.05). A higher prevalence of symptoms of dysmenorrhea, dyspareunia, chronic pelvic pain, infertility and intestinal or urinary changes was observed in the case group when compared with the control group. The

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Section: Discussionmentioning

confidence: 82%

Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis

Cardoso

Machado

Ferrari

et al. 2017

Rev Bras Ginecol Obstet

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“…Four of the studies evaluated predictive measures for deep-infiltrating endometriosis specifically [29–32]. Chapron et al [29] developed a diagnostic model based on symptoms and history, collected via a standardized self-administered questionnaire, to predict posterior deep-infiltrating endometriosis among women with chronic pelvic pain symptoms.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, Bezerra Barcellos et al [32] assessed anatomical areas affected by endometriosis using disease sites from medical history, physical examination, parity, symptoms (i.e., dysmenorrhea, hypermenorrhea, nonmenstrual pelvic pain, dyspareunia, dyschezia, and or urinary symptoms), and image evaluation [33]. The authors compared preoperative and postoperative diagnoses in patients referred for deep-infiltrating endometriosis.…”

Section: Resultsmentioning

confidence: 99%

“…Several measures involved complex mathematical scoring, and may be of less immediate value as patient screening tools (e.g., [19, 21, 24]). Some measures demonstrated good diagnostic accuracy, but only for endometriosis at specific sites (e.g., bladder [28], deep-infiltrating endometriosis [29, 32]). Location of a patient’s endometriosis would not be the objective of a patient-driven screening questionnaire.…”

Section: Discussionmentioning

confidence: 99%

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Patient-completed or symptom-based screening tools for endometriosis: a scoping review

Surrey

Carter

Soliman

et al. 2017

Arch Gynecol Obstet

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PurposeThe objective of this review was to evaluate existing patient-completed screening questionnaires and/or symptom-based predictive models with respect to their potential for use as screening tools for endometriosis in adult women. Validated instruments were of particular interest.MethodsWe conducted structured searches of PubMed and targeted searches of the gray literature to identify studies reporting on screening instruments used in endometriosis. Studies were screened according to inclusion and exclusion criteria that followed the PICOS (population, intervention, comparison, outcomes, study design) framework.ResultsA total of 16 studies were identified, of which 10 described measures for endometriosis in general, 2 described measures for endometriosis at specific sites, and 4 described measures for deep-infiltrating endometriosis. Only 1 study evaluated a questionnaire that was solely patient-completed. Most measures required physician, imaging, or laboratory assessments in addition to patient-completed questionnaires, and several measures relied on complex scoring. Validation for use as a screening tool in adult women with potential endometriosis was lacking in all studies, as most studies focused on diagnosis versus screening.ConclusionsThis literature review did not identify any fully validated, symptom-based, patient-reported questionnaires for endometriosis screening in adult women.

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“…El diagnóstico inicial y la planeación del manejo se basan en los hallazgos clínicos e imagenológicos, pero el definitivo lo confirma el estudio histopatológico (2,12,13). Los síntomas asociados son dolor pélvico incapacitante (28-37 %), dismenorrea (86-94 %), dispareunia profunda (69-59 %), disquecia (30-35 %), diarrea menstrual o estreñimiento, rectorragia o infertilidad (23-50 %) (1,14). El examen físico tiene sensibilidad (S) de 72 % y especificidad (E) de 54 % para el diagnóstico de lesiones en rectosigmoides y una S de 68 % y E del 46 % para las lesiones retrocervicales (2).…”

Section: Introductionunclassified

Seguridad del manejo laparoscópico de pacientes con endometriosis infiltrativa profunda, en un centro de referencia en Pereira, Colombia. Cohorte retrospectiva, 2007-2016

Zambrano-Moncayo¹,

López-Jaramillo²,

López-Isanoa³

et al. 2019

Rev. Colomb. Obstet. Ginecol.

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Objetivo: describir los hallazgos intraoperatorios, los procedimientos realizados y la seguridad del manejo quirúrgico por vía laparoscópica de la endometriosis infiltrativa profunda (EIP). Materiales y métodos: cohorte histórica descriptiva. Ingresaron pacientes con sospecha diagnóstica prequirúrgica de EIP por hallazgos clínicos, ultrasonido pélvico o imágenes de resonancia magnética y con confirmación histológica de la enfermedad. Las pacientes fueron llevadas a cirugía mínimamente invasiva entre 2007 y 2016, en una institución de salud de referencia ubicada en Pereira, Colombia. Se evaluaron variables sociodemográficas, clínicas, hallazgos intraoperatorios, tipos de procedimientos realizados, complicaciones intra y posoperatorias y control del dolor a las 6 semanas. Se hace un análisis descriptivo. Resultados: se incluyeron 167 pacientes. La localización más frecuente de la enfermedad fue el tabique recto-vaginal (85,7 %). Un total de 83 pacientes (49,7 %) presentaron endometriosis intestinal. De estas, al 86 % se les realizó shaving (afeitado o nodulectomía), y al 13,2 % resección intestinal segmentaria. Un total de 4 pacientes (2,3 %) presentaron complicaciones intraoperatorias, de las cuales una requirió laparoconversión y otras 6 pacientes (3,5 %) desarrollaron complicaciones posoperatorias. Conclusiones: el manejo laparoscópico de la EIP es una alternativa por considerar, con una frecuencia de complicaciones cercana al 6 %. Se requieren estudios aleatorizados con grupo control para una mejor evaluación de la seguridad y eficacia.

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Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis

Abstract: The results show a high sensitivity, specificity and accuracy of the preoperative clinical evaluation to identify the main sites of endometriosis lesions without the use of diagnostic laparoscopy.

Cited by 11 publications

References 13 publications

Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis

Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis

Patient-completed or symptom-based screening tools for endometriosis: a scoping review

Seguridad del manejo laparoscópico de pacientes con endometriosis infiltrativa profunda, en un centro de referencia en Pereira, Colombia. Cohorte retrospectiva, 2007-2016

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