Agreement in Left Ventricular Function Measured by Echocardiography and Cardiac Magnetic Resonance in Patients With Chronic Coronary Total Occlusion

Li, Jiahui; Zhang, Lijun; Wang, Yue-Li; Zuo, Houjuan; Huang, Rongchong; Yang, Xiumin; Han, Young-Min; He, Yi; Song, Xiaoyan

doi:10.3389/fcvm.2021.675087

Cited by 2 publications

(1 citation statement)

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“…Patients with STEMI with ≥ 20% increase in LVEDV and ≥ 5% decrease in LVEF from baseline were considered to have adverse structural LV remodeling ( 17 ). Transthoracic echocardiography was assessed using 2-dimensional imaging (Philips EPIQ Elite) according to the recommendations for cardiac chamber quantification ( 18 , 19 ). The view of left ventricle from either the patients or healthy volunteers was placed in the left supine position by the parasternal long axis.…”

Section: Methodsmentioning

confidence: 99%

Plasma Exosome miRNAs Profile in Patients With ST-Segment Elevation Myocardial Infarction

Guan

Zeng

Zhang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundCirculating microRNAs (miRNAs) have been found to have different expressions in different phases of acute myocardial infarction. The profiles of plasma exosome miRNAs in patients with ST-segment elevation myocardial infarction (STEMI) at 3–6 months postinfarction are unknown.ObjectiveThe aim of this study was to assess the profiles of plasma exosome miRNAs in patients with STEMI in comparison with healthy volunteers and to select specific exosome miRNAs related to pathophysiological changes post-STEMI.MethodsPlasma and echocardiography parameters were collected from 30 patients 3–6 months after STEMI and 30 healthy volunteers. Plasma exosome miRNAs were assessed by using high-throughput sequence (Illumina HiSeq 2500) and profile of the plasma exosome miRNAs was established in 10 patients and 6 healthy volunteers. The specific exosome miRNAs related to heart diseases were selected according to the TargetScan database. The specificity of the selected exosome miRNAs was evaluated in additional 20 post-STEMI patients and 24 healthy volunteers by using quantitative PCR (qPCR). Left ventricular remodeling (LVR) was defined using the European Association of Cardiovascular Imaging criteria according to echocardiography examination. Correlations between expression of the specific miRNAs and echocardiography parameters of LVR were assessed using the Spearman correlation analysis.ResultsTwenty eight upregulated miRNAs and 49 downregulated miRNAs were found in patients 3–6 months after STEMI (p < 0.01) in comparison with the healthy volunteers. The two least expressed and heart-related exosome miRNAs were hsa-miR-181a-3p (0.64-fold, p < 0.01) and hsa-miR-874-3p (0.50-fold, p < 0.01), which were further confirmed by using qPCR and demonstrated significant specificity in another 20 patients with post-STEMI comparing to 24 healthy volunteers [area under the curve (AUC) = 0.68, p < 0.05; AUC = 0.74, p < 0.05]. The expression of hsa-miR-181a-3p was downregulated in patients with LV adverse remodeling in comparison with patients without LV adverse remodeling and healthy volunteers.ConclusionCirculating exosome miR-874-3p and miR-181a-3p were downregulated in patients with STEMI postinfarction. Exosome hsa-miR-181a-3p might play a potential role in the development of LVR in patients with post-STEMI.

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Section: Methodsmentioning

confidence: 99%