Agreement of specific IgE and skin prick test in an unselected cohort of two-year-old children

Abstract

In young children total IgE is of limited value when evaluating allergy-related disorder. The lack of agreement among the positive tests of the sIgE and SPT for some allergens imply that these tests should not be used interchangeably, and both tests should probably be used complementarily when diagnosing atopic sensitization in small children.

Breast-feeding does not protect against allergic sensitization in early childhood and allergy-associated disease at age 7 years

“…[22][23][24] Likewise, monosensitized and polysensitized patients with allergic rhinitis have been suggested to constitute 2 different categories, 25 which is why we also chose to perform subanalyses based on whether the child was monosensitized or polysensitized.…”

Atopic endotype in childhood

“…Importantly, the specificity and sensitivity of the method applied for diagnosing allergic sensitization varies significantly for skin prick test and sIgE results. 11,22,23 There is a profound disagreement between skin prick test responses [24][25][26][27] and sIgE results [27][28][29] to the same allergens, and this disagreement changes with age. Therefore the distinction of the atopic endotype depends on the group of allergens included (inhalant allergens, food allergens, or both), as well as the tools used to determine allergic sensitization, and depends strongly on the age of the child tested.…”

Skin prick tests and specific IgE in 10‐year‐old children: Agreement and association with allergic diseases

“…In a Norwegian study that compared sIgE measurement and SPT in 2‐year‐old children, both tests yielded different results and were not similar for the detection of atopic sensitization. The authors concluded that both tests actually reflected distinct aspects of the IgE‐related immune response.…”

“…Using SPT≥3 mm and/or sIgE≥0.35 IU/mL as the definition of atopic sensitization improves sensitivity, but at the cost of lower specificity, In a Norwegian study 26 The differences between farmers and nonfarmers are not highlighted here because this was beyond the scope of the present study.…”