The GeoWEPP model has estimated water and soil losses caused by erosion at the watershed level in different parts of the world. However, this model was developed and its parameters have been adjusted for temperate climates, which are different from tropical climates such as those found in Brazil. Our study evaluated the performance of the GeoWEPP model in estimating soil erosion in three micro-watersheds in the Cerrado (i.e., savannah) of southeastern Mato Grosso state, Brazil. Major land uses modeled were soybean and corn cultivation, traditional pasture, and native vegetation. Input parameters for the GeoWEPP model involved climate, soil, land use and management, and topography. GeoWEPP was calibrated with input parameters for soil erodibility specified as interrill and rill soil erosion, soil critical shear stress, and saturated hydraulic conductivity obtained experimentally and estimated by internal routine equations of the GeoWEPP model. Soil losses observed in micro-watersheds with agriculture, pasture, and native vegetation were 0.11, 0.06, and 0.10 metric tons per hectare per year, respectively. GeoWEPP best modeled soil erosion for native vegetation and pasture, while over-estimating that for crops. Surface runoff was best modeled for crops versus native vegetation and pasture. The GeoWEPP model performed better when using soil erodibility input parameters.