Agriculture and Agri-Food Canada’s research program on antimicrobial resistance

Topp, Edward

doi:10.14745/ccdr.v43i11a03

Cited by 16 publications

(18 citation statements)

References 14 publications

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“…Farming practices may be improving to reduce LA-MRSA transmission risk, including methods to keep animals healthy without the need for antibiotics; such as the use of vaccines, nutritional supplements, prebiotics, probiotics or synbiotics, and waste management strategies. 57 Veterinarians are more informed than ever about the risks of antimicrobial resistance; hence, they are careful in their own use of antibiotics with animals as well as the advice that they provide to livestock and poultry farmers. However, changes in the prevalence in control populations may also contribute to the change in risk of colonisation over time.…”

Section: Systematic Reviewmentioning

confidence: 99%

Livestock-associated methicillin-resistantStaphylococcus aureus(LA-MRSA) colonisation and infection among livestock workers and veterinarians: a systematic review and meta-analysis

Chen

2020

Occup Environ Med

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ObjectivesMethicillin-resistant Staphylococcus aureus (MRSA) is an increasing public health concern worldwide. The objective of this study was to calculate a summary odds ratio (OR) of livestock-associated MRSA colonisation and infection in humans, and to determine specific risk factors in livestock production contributing to MRSA colonisation.MethodsWe screened PubMed and Embase for studies published from 2005 to 2019 inclusive, reporting livestock-associated (LA)-MRSA colonisation and infection among livestock workers/veterinarians, their families, and community members not regularly exposed to livestock. The primary outcome of interest was the OR of LA-MRSA colonisation comparing exposed and control groups. Quality was assessed according to the Newcastle-Ottawa quality assessment scale. A meta-analysis using a random-effects model was conducted to calculate a pooled OR. The heterogeneity in the meta-analysis was assessed using the I² method, and publication bias was evaluated using funnel plots.ResultsA total of 3490 studies were identified by the search, with 37 studies including 53 matched exposed-control groups and 14 038 participants eligible for the meta-analysis. The pooled OR for LA-MRSA among livestock workers and veterinarians is 9.80 (95% CI 6.89 to 13.95; p=0.000; I2=73.4), with no significant publication bias (Egger’s p=0.66). The OR for swine workers was highest at 15.41 (95% CI 9.24 to 25.69), followed by cattle workers (11.62, 95% CI 4.60 to 29.36), veterinarians (7.63, 95% CI 3.10 to 18.74), horse workers (7.45, 95% CI 2.39 to 23.25), livestock workers (5.86, 95% CI 1.14 to 30.16), poultry workers (5.70, 95% CI 1.70 19.11), and industrial slaughterhouse workers (4.69, 95% CI 1.10 to 20.0).ConclusionsLivestock workers, particularly swine farmers, are at significantly higher risk for LA-MRSA colonisation and subsequent infection. These results support the need for preventive practices to reduce LA-MRSA risk among those who handle and treat livestock.Trial registration numberCRD42019120403.

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Section: Systematic Reviewmentioning

confidence: 99%

Livestock-associated methicillin-resistantStaphylococcus aureus(LA-MRSA) colonisation and infection among livestock workers and veterinarians: a systematic review and meta-analysis

Chen

2020

Occup Environ Med

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“…Antimicrobial resistance in food animals is a major concern due to the potential dissemination of resistant bacteria to humans via the food chain [12]. According to Mcewen and Fedorka-Cray [13], antimicrobial-resistant bacteria may leak and contaminate meat during slaughtering and could transfer to humans through food.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Multidrug-Resistant Foodborne Pathogens and Indicator Bacteria from Edible Offal and Muscle Meats in Nashville, Tennessee

Liu

Kilonzo‐Nthenge

Nahashon

et al. 2020

Foods

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This study investigated the prevalence of antimicrobial-resistant bacteria in retail edible offal and muscle meats in Nashville, Tennessee. A total of 348 retail meats (160 edible offal and 188 muscle) were analyzed for Salmonella enterica serovar, Campylobacter, Escherichia coli, E. coli O157:H7, and enterococci. Bacteria was identified using biochemical and PCR methods. Salmonella enterica serovar (4.4% and 4.3%), Campylobacter (1.9% and 1.1%), E. coli (79.4% and 89.4%), and enterococci (88.1% and 95.7%) was detected in offal and muscle meats, respectively. Chicken liver (9.7%) was most frequently contaminated with Salmonella enterica serovar, followed by ground chicken (6.9%) and chicken wings (4.2%). No Salmonella enterica serovar was detected in beef liver, beef tripe, and ground beef. The prevalence of Campylobacter was 6.9%, 2.3%, and 1.4% in beef liver, ground beef, and ground chicken, respectively. None of the meats were positive for E. coli O157:H7. Resistance of isolates was significantly (p < 0.05) highest in erythromycin (98.3%; 99.1%), followed by tetracycline (94%; 98.3%), vancomycin (88.8%; 92.2%) as compared to chloramphenicol (43.1%; 53.9%), amoxicillin/clavulanic (43.5%; 45.7%), and ciprofloxacin (45.7%; 55.7%) in offal and muscle meats, respectively. Imipenem showed the lowest resistance (0%; 0.9%). A total of 41 multidrug-resistant patterns were displayed. Edible offal could be a source of antibiotic-resistant bacteria.

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“…The current biological control of soil‐borne diseases is mainly focused on beneficial microorganisms that can be cultured, and the mechanism of disease resistance has also been reported in detail, but these microorganisms are not always stable in the field (Deshwal et al., 2003; Haas & Defago, 2005; Mazzola & Freilich, 2017). Future research is needed to be focused on the abundance and diversity of “natural” resistance in soil communities (Topp, 2017) to maintain the resistance and resilience of microbial communities.…”

Section: Resultsmentioning

confidence: 99%

Identification and verification of rhizosphere indicator microorganisms in tobacco root rot

et al. 2021

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This study aimed to investigate the characteristics of the microbial community in the rhizosphere of tobacco (Nicotiana tabacum L.) and explore the potential microbiological indicators of tobacco root rot Rhizosphere soils of healthy and diseased tobacco over different continuous cropping years were sampled, and total DNA was extracted from the soils. Afterward, 16S rRNA combined with internal transcribed spacer gene sequencing was used to study the differences in microbial communities in the rhizosphere. A pot experiment was conducted to evaluate the effects of Paenibacillus polymyxa and Trichoderma harzianum on root rot, and the relative abundance of Fusarium, Rubrobacter, and Talaromyces spp. as the potential indicators of tobacco health were identified by sequencing data Bacterial and fungal diversity decreased with the increase in years of continuous cropping. The bacterial and fungal diversity in the rhizosphere with tobacco root rot was higher than that in the healthy rhizosphere. Rubrobacter and Talaromyces spp. were more abundant in the rhizosphere soil of healthy tobacco than in that of diseased tobacco. Paenibacillus polymyxa and T. harzianum treatment led to an increase in the relative abundance of Rubrobacter and Talaromyces spp., implying that this treatment could have a plantpromoting effect Rubrobacter and Talaromyces spp. may serve as beneficial microbiological indicators of tobacco root rot, and P. polymyxa and T. harzianum may serve as antagonistic strains for the biocontrol of tobacco root rot.

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Agriculture and Agri-Food Canada’s research program on antimicrobial resistance

Cited by 16 publications

References 14 publications

Livestock-associated methicillin-resistantStaphylococcus aureus(LA-MRSA) colonisation and infection among livestock workers and veterinarians: a systematic review and meta-analysis

Livestock-associated methicillin-resistantStaphylococcus aureus(LA-MRSA) colonisation and infection among livestock workers and veterinarians: a systematic review and meta-analysis

Prevalence of Multidrug-Resistant Foodborne Pathogens and Indicator Bacteria from Edible Offal and Muscle Meats in Nashville, Tennessee

Identification and verification of rhizosphere indicator microorganisms in tobacco root rot

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