With increasing production cost, southeast U.S. peanut (Arachis hypogaea L.) growers are continually seeking to lower inputs to enhance economical return and sustainability of their farming operation. Utilization of peanut cultivars with the best combination of disease resistance, drought tolerance, and greatest dollar value return would be beneficial. Fifteen peanut cultivars were evaluated for 5-years (2011–15) and seventeen cultivars were evaluated for 4-years (2012–15) with minimum inputs and without irrigation at two locations in Georgia. Each year, minimum inputs for disease control included only three fungicide sprays at recommended rates on a 28 d schedule beginning 37 d after planting. No insecticide, nematocides, miticides, or irrigation were applied during the growing seasons each year. ‘Georgia-06G', ‘Georgia-12Y', ‘Georgia-13M', ‘Georgia-14N', and Florida-EP ‘113’ had the lowest TSWV and total disease incidence (disease resistance) among the ten runner-type cultivars for both Georgia locations; whereas, ‘Bailey', ‘Georgia-08V', and ‘Georgia-11J' had the least disease incidence among the five virginia-type cultivars. Similarly, Georgia-13M, Georgia-06G, and Georgia-12Y had the greatest gross dollar value return per hectare (drought tolerance) among the runner-types; whereas, Georgia-08V and Georgia-11J had the greatest dollar values per hectare among the virginia-type cultivars at both Georgia locations in this four and five-year study, respectively.