1998
DOI: 10.1016/s0065-2571(97)00013-7
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Ah receptor-controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms

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Cited by 37 publications
(15 citation statements)
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“…It is known that UGT1A1, UGT1A6, and UGT1A9 can be regulated by chemicals that promote activation of the Ah receptor (18,20), whereas UGT1A1, UGT1A3, and UGT1A4 are targets for the xenobiotic receptors PXR or constitutive androstane receptor (16,17,23). However, whereas these studies are informative, an appropriate model to examine the tissue-specific and inducible properties of the UGT1 locus and the functional outcome of these expression patterns has been lacking.…”
Section: Discussionmentioning
confidence: 99%
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“…It is known that UGT1A1, UGT1A6, and UGT1A9 can be regulated by chemicals that promote activation of the Ah receptor (18,20), whereas UGT1A1, UGT1A3, and UGT1A4 are targets for the xenobiotic receptors PXR or constitutive androstane receptor (16,17,23). However, whereas these studies are informative, an appropriate model to examine the tissue-specific and inducible properties of the UGT1 locus and the functional outcome of these expression patterns has been lacking.…”
Section: Discussionmentioning
confidence: 99%
“…Tract-Several human UGTs have been shown to be regulated by activators of the Ah receptor (18,20) and the PXR (16,23). To look selectively at the induction of the UGT1 locus in Tg-UGT1 mice, Tg-UGT 1c mice were bred, and three mice per group were selected for treatment with the either TCDD (16 g/kg) or PCN (100 mg/kg).…”
Section: Induction Of the Ugt1 Locus By Ah Receptor And Pxr Activatormentioning
confidence: 99%
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“…The results indicated that only 3-methylcholanthrene could enhance catechol glucuronidation, thus indicating that UGT isoforms (UGT1 family) could be involved in catechol glucuronidation. The PAH type of induction, e.g., by 3-methylcholanthrene, ␤-naphthoflavone, 2,3,7,8-tetrachlorodibenzo-p-dioxin, PAH, or PCB, is regulated by aryl hydrocarbon receptor, which functions as a ligand-activated transcription factor in over-expression of the forms rUGT1A6, rUGT1A7, hUGT1A6, and hUGT1A9 (Bock et al, 1998(Bock et al, , 1999. Other typical coeffects achieved by using Aroclor 1254 as the inducing PCB agent (Safe, 1994) are a phenobarbital type of induction and hepatomegaly, which accounted for a 55% increase in the liver weights (Table 1).…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, phenobarbital had no significant effect. 3-MC and related polycyclic aryl hydrocarbons, such as dioxin, are known to specifically increase the expression of UGT1A6 in rat (Bock et al, 1998). Such induction could account for the stimulation effect of 3-MC found in rat liver microsomes.…”
Section: Hepatic Glucuronidation Of Catechols In Ratmentioning
confidence: 95%