Context: The integration of ChatGPT and e-health literacy, as an innovative approach to improving the accessibility and quality of healthcare services, offers the potential to strengthen access to health information and health decision-making. This integration helps individuals understand, analyze, and interpret health information more deeply while building a broad health profile. However, the potential risk of ChatGPT misdiagnosing diseases or providing inaccurate information could cause misleading guidance and prevent users from accessing information. Moreover, a ChatGPT-based system could restrict individuals' capacity to supervise and decipher their health records. Thus, while the integration of ChatGPT and e-health literacy holds promise to improve the accessibility and quality of health services, adverse aspects, such as the risk of providing misleading information and reducing user autonomy, should also be considered. Evidence Acquisition: This study provides insight into the potential, challenges, and prospects of integrating ChatGPT and e-health literacy into health services. Thus, the implication of the integration and the development of strategies for helping users better manage their health information can be explored in greater depth. Related articles on the topic were reviewed from the literature, and the results were interpreted. Results: The integration of ChatGPT with eHealth literacy harbors significant potential for substantially enhancing the accessibility and quality of health services. Using ChatGPT in health services can increase eHealth literacy, especially in health information access and health-related decision-making processes. Conclusions: In conclusion, the integration of ChatGPT and eHealth literacy carries considerable potential to improve the accessibility and quality of health services. This integration allows individuals to comprehend health data more efficiently and interpret the results more accurately.