AIDS and the oral cavity. The HIV-infection: Virology, etiology, origin, immunology, precautions and clinical observations in 110 patients

Reichart, Peter A.; Gelderblom, Hans R.; Becker, Jürgen C.; Kuntz, Angelika

doi:10.1016/s0901-5027(87)80122-4

Cited by 98 publications

(48 citation statements)

References 99 publications

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“…It was first described in HIV infeeted homosexual men, later as well in all other groups at risk for HIV-infection (3,4), HL has been considered to be a highly predictive lesion for the development of AIDS (28), a fact which has also been stated in the present study. The correlation between the clinical finding or later development of HL with the progression of HIV-associated disease may be reflected in the imtnunoeytoehemical results for EBV: while 61% of HIV-I-patients and 84% of HIV-f patients with HL showed positive results for EBV, only five of 17 patients without presence or later development of HL were EBV antigen positive.…”

Section: Discussionsupporting

confidence: 78%

“…Continuous viral, bacterial or mycotic stimulation, modification of the epithelial structure and local or systemie immunologie alterations can lead to disturbances of the mucosal barrier function, resulting in elinieal and morphologieal alterations and dysfunetions of the mucosa (2). During HIV-infection different oral manifestations are found (3). Oral lesions due to herpes viruses are of special clinical relevanee, sueh as the EBV assoeiated hairy leukoplakia (4,5), or CMV induced ulcerations (6), and often show unusual clinical symptoms, localization and/or resistance to therapies.…”

mentioning

confidence: 99%

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Immunocytochemical detection of herpes viruses in oral smears of HIV‐infected patients

Langford

Kunze²,

Schmelzer

et al. 1992

J Oral Pathology Medicine

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Langford A, Kunze R, Sehmelzer S, Wolf H, Pohle H-D, Reichart P: Immunocytochemical detection of herpes viruses in oral smears of HIV-infected patients. J Oral Pathol Med 1992; 21: 49-57.Cytologie smears (CS) were taken from the lateral border of the tongue of HIVseropositive patients (HlV-f) {n = 39) and of seronegative controls (HIV-) (n = 19) and examined by immunocytochemistry (APAAP) and in situ hybridization (ISH) (biotinylated DNA probes) for the presence of viral antigens/DNA of EBV and CMV. While none of the HIV controls showed positive results for EBV antigen, 61% (APAAP) resp. 79% (ISH) of oral epithelial eells in the group of HIV-I-patients were EBV-positive. While all CS taken from areas with the elinical diagnosis of hairy leukoplakia (HL) were EBV positive (APAAP and/ or ISH), the detection of EBV in CS from uninvolved oral mueosa seemed to be assoeiated with the later development of HL. In the group of HIV-I-patients the detection rate for CMV was about five times (APAAP) resp. three times (ISH) higher than in HIV-persons. This non-invasive technique seems to be a valuable tool to screen for viral antigens/getioms.

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Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

Immunocytochemical detection of herpes viruses in oral smears of HIV‐infected patients

Langford

Kunze²,

Schmelzer

et al. 1992

J Oral Pathology Medicine

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“…OPC is the most common oral manifestation of HIV infection, a significant indicator of CD4ϩ numbers, a marker for seroconversion illness, and a first clinical sign of immunosuppression during the progression of HIV to AIDS (Langlais & Miller, 1998;Reichert, Gelderblow, Becker, & Kuntz, 1987). A number of oral conditions suggest HIV infection in nondiagnosed subjects.…”

Section: Oral Disease Associated With Hiv Infectionmentioning

confidence: 99%

“…Herpes simplex virus infections usually appear on the lips as herpes labialis or in the mouth on keratinized epithelium. Unlike patients with normal immune function, HIVinfected individuals may have herpetic lesions on mucosal surfaces such as the tongue (Langlais & Miller, 1998;Reichert et al, 1987). Recurrent viral infections are more frequent, more persistent, and more severe with HIV immunosuppression.…”

Section: Oral Disease Associated With Hiv Infectionmentioning

confidence: 99%

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Stress Reduction as a Means to Enhance Oral Immunity in HIV-Infected Individuals

Hand¹,

Phillips²,

Dudgeon³

et al. 2005

Journal of the Association of Nurses in AIDS Care

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Human immunodeficiency virus type 1 and cytomegalovirus in saliva

Lucht

Albert

Linde

et al. 1993

Journal of Medical Virology

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The aim of this study was to evaluate whether HIV-1 or cytomegalovirus (CMV) may contribute to oral lesions frequently found in patients with the acquired immunodeficiency syndrome (AIDS). Saliva samples from 63 HIV-1 positive patients and 21 healthy controls were tested for the presence of HIV-1 and CMV using the polymerase chain reaction (PCR) and virus isolation. CMV IgG titres in serum were also compared in the different groups. HIV-1 RNA, but not DNA, was detected in saliva from 15% (9 out of 59) of the HIV-infected patients. There was no correlation between the presence of HIV-1 RNA and oral symptoms in the patients. CMV DNA was detected significantly more frequently in samples from HIV-1 seropositive than from seronegative patients. CMV was detected in saliva from AIDS patients more often than in saliva from patients with mild or no symptoms. CMV IgG titres were also significantly higher in symptomatic than in asymptomatic patients. There was a significant correlation between the presence of CMV DNA and necrotizing gingivitis, and oral Kaposi's sarcoma in the patients, and also between these lesions and the stage of disease. This does not prove that CMV causes these oral lesions, but a direct or indirect role for CMV cannot be excluded.

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AIDS and the oral cavity. The HIV-infection: Virology, etiology, origin, immunology, precautions and clinical observations in 110 patients

Cited by 98 publications

References 99 publications

Immunocytochemical detection of herpes viruses in oral smears of HIV‐infected patients

Immunocytochemical detection of herpes viruses in oral smears of HIV‐infected patients

Stress Reduction as a Means to Enhance Oral Immunity in HIV-Infected Individuals

Human immunodeficiency virus type 1 and cytomegalovirus in saliva

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