This article presents three cross-cutting intervention case studies that address HIV, AIDS, and natural resources management in an integrated manner through innovative programming in Zimbabwe, Uganda, and Malawi. In Zimbabwe, a religious-based non-governmental group and two community organizations work together to build skills of HIV-and AIDS-vulnerable children in rural areas to meet dietary and income needs, while using natural resources sustainably. In Uganda, various government agencies and NGO actors work together to improve the food security of HIV-affected households at the national, district, sub-district, and village levels. Finally, in Malawi, a conservation organization incorporates HIV and AIDS Roger-Mark De Souza-Formerly with the Population Reference Bureau. awareness and programming into its operations and projects. Each case study presents pioneering approaches to simultaneously addressing the pressures on conservation initiatives, food security/agricultural production, income generation/ livelihoods, and social and health care systems. They also provide lessons for expanding interventions and partnerships.Intervention projects that bring together components of HIV and AIDS education and mitigation with natural resource management are emerging as innovative, crosscutting approaches to address the on-the-ground complexities between HIV, AIDS, and the environment as revealed by the scholarship in this special issue. These intervention projects yield interesting questions related to form, impact, and replicability. What do such projects look like? What are the benefits of these approaches? Can they be scaled up and at what level? The three intervention case studies reviewed here provide a noteworthy start to examine such questions.The first case study on Junior Farmer Field Schools by Heinrich and Senefeld addresses the vulnerability of children and HIV and AIDS orphans in Zimbabwe by partnering with a religious-based non-governmental group and two community organizations. Overall, the project works to build skills of HIV-and AIDSvulnerable children in rural areas to meet dietary and income needs while also using natural resources sustainably. Its innovation lies in the adaptation of the wellestablished Farmer Field Schools (FFS) methodology which implements a series of non-formal, participatory, and hands-on activities according to the agricultural production cycle. This project adopted traditional FFS approaches, and added targeted outreach to, and the incorporation of, children. In addition, the project included HIV and AIDS awareness, prevention, and mitigation components, as well as training on basic business skills.Partners for Food Security, the second intervention case study by Coon, Sebanja, and Ogden, represents an inter-agency partnership in Uganda dedicated to improving the food security of HIV-affected households. Partners provides