The local wisdom of indigenous people in nature conservation plays a critical part in protecting the planet’s biodiversity and the overall health of the ecosystems. However, at the same time, indigenous people and their lands are facing immense threats through modernization and globalization. This study aims to systematically review and analyze the local wisdom of the indigenous people in nature conservation. The present study integrated multiple research designs, and the review was based on the published standard, namely the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). This study used Web of Science (WoS) and Scopus as the main databases in searching for the required articles. Through content analysis, this study can be divided into seven main categories: (a) forest management, (b) flora and fauna conservation, (c) food security, (d) water management, (e) land management, (f) weather forecasting, and (g) others. The findings offer some basics on how academics can adopt and adapt the existing local wisdom of indigenous people in nature conservation into the scientific framework and design to answer the Sustainable Development 2030 Agenda.