AIE-active two-photon fluorescent nanoprobe with NIR-II light excitability for highly efficient deep brain vasculature imaging

Samanta, Soham; Huang, Meina; Li, Shaoqiang; Yang, Zhigang; He, Ying; Gu, Zhenyu; Zhang, Jianguo; Zhang, Dan; Liu, Liwei; Qu, Junle

doi:10.7150/thno.53780

Cited by 39 publications

(22 citation statements)

References 42 publications

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“…Here, mouse brain vessels as small as 3.17 µm were imaged. The AIEdots prepared from compound 72 by Samanta et al also allowed 800 μm brain tissue penetration under 2PE at 1040 nm (Table 3) (Samanta et al, 2021). Interestingly, record absorption capacity and unprecedented 2P brightness values (>10 4 GM) were measured for the tetraphenylethene-BODIPY (75) AIEDots made by Wang et al, but the reported penetration depth was not higher than in more recent studies (700 µm vs. 1200 µm) (Wang et al, 2015).…”

Section: In Vivo Examples Of 2p Nir-ii Imagingmentioning

confidence: 87%

“…Outside of the BTZ class of dyes, a 2PA fluorescent nanoprobe made of a triphenylamine-based brominated AIEgen (dye 72) (Samanta et al, 2021), showing a similar structure to dipole 59 (Section 2.1.5), was reported. The triphenylamine ED group provides a good balance between strong twisted ICT in the molecule and unrestricted rotation to ensure possible AIE.…”

Section: Aggregation Induced Emission Dyes and Dotsmentioning

confidence: 99%

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Two-Photon Absorption: An Open Door to the NIR-II Biological Window?

et al. 2022

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The way in which photons travel through biological tissues and subsequently become scattered or absorbed is a key limitation for traditional optical medical imaging techniques using visible light. In contrast, near-infrared wavelengths, in particular those above 1000 nm, penetrate deeper in tissues and undergo less scattering and cause less photo-damage, which describes the so-called “second biological transparency window”. Unfortunately, current dyes and imaging probes have severely limited absorption profiles at such long wavelengths, and molecular engineering of novel NIR-II dyes can be a tedious and unpredictable process, which limits access to this optical window and impedes further developments. Two-photon (2P) absorption not only provides convenient access to this window by doubling the absorption wavelength of dyes, but also increases the possible resolution. This review aims to provide an update on the available 2P instrumentation and 2P luminescent materials available for optical imaging in the NIR-II window.

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Section: In Vivo Examples Of 2p Nir-ii Imagingmentioning

confidence: 87%

Section: Aggregation Induced Emission Dyes and Dotsmentioning

confidence: 99%

Two-Photon Absorption: An Open Door to the NIR-II Biological Window?

et al. 2022

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“…As a common approach to generating a high-energy fluorescence signal in the visible region from low-energy irradiation in the NIR region, two-photon fluorescence imaging provides a unique and clear optical window for in vivo imaging, which has advantages of deep-tissue penetration, low autofluorescence, and low phototoxicity. Numerous AIEgens have been investigated for two-photon fluorescence imaging on brain vasculature [53][54][55][56][57][58][59][60][61][62]. They were all designed with a high two-photon absorption cross section and large quantum yield to contribute to deep penetration and high resolution.…”

Section: Two-photon Fluorescence Imagingmentioning

confidence: 99%

Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens

Cen

Zhou

Cui

et al. 2022

Eur J Nucl Med Mol Imaging

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Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission luminogens (AIEgens) have been regarded as good candidates in many biomedical applications. They display a large Stokes shift, high quantum yield, good biocompatibility, and resistance to photobleaching. Neurological diseases are becoming a substantial burden on individuals and society that affect over 50 million people worldwide. It is urgently needed to explore in more detail the brain structure and function, learn more about pathological processes of neurological diseases, and develop more efficient approaches for theranostics. Many AIEgens have been successfully designed, synthesized, and further applied for molecular imaging and image-guided theranostics in neurological diseases such as cerebrovascular disease, neurodegenerative disease, and brain tumor, which help us understand more about the pathophysiological state of brain through noninvasive optical imaging approaches. Herein, we focus on representative AIEgens investigated on brain vasculature imaging and theranostics in neurological diseases including cerebrovascular disease, neurodegenerative disease, and brain tumor. Considering different imaging modalities and various therapeutic functions, AIEgens have great potential to broaden neurological research and meet urgent needs in clinical practice. It will be inspiring to develop more practical and versatile AIEgens as molecular imaging agents for preclinical and clinical use on neurological diseases.

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“…Encouragingly, AIETP NPs not only exhibited excellent cell permeability and biocompatibility but also exhibited good two-photon imaging properties in vivo. Moreover, due to the superior penetration depth (800 μm) and excellent spatial resolution (1.92 μm), AIETP NPs were applied to deep brain imaging in vivo [ 35 ]. SPNPs are organic semiconducting macromolecules whose backbone consists of alternating single and double bonds.…”

Section: Nir-ii Fluorescent Probesmentioning

confidence: 99%

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Pan

et al. 2021

Biosensors

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Recently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific targeting to biological tissues, showing a higher imaging signal-to-background ratio and a lower detection limit. Therefore, it is of great significance to utilize disease-associated endogenous stimuli (such as pH values, enzyme existence, hypoxia condition and so on) to activate the NIR-II probes and achieve switchable fluorescent signals for specific deep bioimaging. This review introduces recent strategies and mechanisms for activatable NIR-II fluorescent probes and their applications in biosensing and bioimaging. Moreover, the potential challenges and perspectives of activatable NIR-II fluorescent probes are also discussed.

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AIE-active two-photon fluorescent nanoprobe with NIR-II light excitability for highly efficient deep brain vasculature imaging

Cited by 39 publications

References 42 publications

Two-Photon Absorption: An Open Door to the NIR-II Biological Window?

Two-Photon Absorption: An Open Door to the NIR-II Biological Window?

Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

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