AIE-based nanoaggregate tracker: high-fidelity visualization of lysosomal movement and drug-escaping processes

Abstract

High-fidelity imaging and long-term visualization of lysosomes are crucial for their function evaluation, related diseases detection and active drug screening. However, the commercial aggregation-caused quenching (ACQ) probes are not conducive...

AIE-active luminogens as highly efficient free-radical ROS photogenerator for image-guided photodynamic therapy

“…24 In addition, AIEgens with "off-on" fluorescence could realize high-fidelity imaging compared to ACQ fluorophore, especially for decreasing false fluorescence signal. [25][26][27][28] Our group have reported a novel AIE building block TCM, 29,30 with high fluorescence in aggregation state, multiple ARTICLE Journal Name 2 | J. Name., 2012, 00, [1][2][3] This journal is © The Royal Society of Chemistry 20xx…”

“…Our group has reported the novel AIE building block TCM, 29,30 which has high fluorescence in the aggregated state, multiple modification sites, and good photostability; TCM is expected to be useful in the construction of photosensitizers through structural regulation (Fig. 1).…”

“…24 In addition, AIEgens with "off-on" uorescence could realize higher-delity imaging compared to ACQ uorophores, especially in terms of decreasing false uorescence signals. [25][26][27][28] Our group has reported the novel AIE building block TCM, 29,30 which has high uorescence in the aggregated state, multiple modication sites, and good photostability; TCM is expected to be useful in the construction of photosensitizers through structural regulation (Fig. 1).…”

Sulfonate‐Functionalized AIEgens: Strategic Approaches Beyond Water Solubility for Sensing and Imaging Applications

“…While water‐soluble conventional fluorophores still suffer ACQ effect at higher concentration, [21,22] water‐soluble AIEgens with better photostability and the ability for non‐covalent interactions with chemical/biological species proved especially useful as light‐up probes from sensing and imaging to theranostic applications [23,24] . With enormous progress in this direction, apart from a range of ionic AIEgens, researchers also paid attention to designing AIE‐luminogen appended smart nanoaggregates (e. g. vesicles, nanoparticles) based on small‐molecule amphiphiles, amphiphilic polymers, block co‐polymers, supramolecules/supramacromolecules because of their multi‐targeting and better binding abilities [25–29] …”

A Nanotheranostic System Combining Lysosomal Cell Death and Nuclear Apoptosis Functions for Synergistic Cancer Therapy and Addressing Drug Resistance

“…Fortunately, aggregation-induced emission (AIE) luminogens have shown great superiority in FLI, especially in longterm imaging, due to their excellent brightness in aggregates, remarkable photostability, large Stokes shift and so on. [26][27][28][29][30][31][32] Therefore, the design of a lysosome-targeting drug with AIE features would be considered as a groundbreaking strategy in cancer theranostics, especially for drug-resistant cancers.…”