Air‐oxidized linalool–a frequent cause of fragrance contact allergy

Abstract

In an international setting, oxidized linalool has been shown to be a common allergen. Oxidized linalool 6.0% (Lin-OOHs 1%) pet. is a useful, standardized and stable tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized linalool would not have been informed of their fragrance allergy if this specific test had not been performed.

Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study

“…Regarding sensitization, no patients were, to our knowledge, actively sensitized during the present study, as no cases of late‐appearing reactions were reported. On the basis of these results, and according to previous recommendations , it seems that patch test preparations of Lim‐OOHs 0.3% pet. and Lin‐OOHs 1.0% pet.…”

“…(containing 0.33% Lim‐OOHs) and 6.9% to oxidized linalool 6.0% pet. (containing 1.0% Lin‐OOHs) . These findings place Lim‐OOHs and Lin‐OOHs among the most common contact allergens throughout Europe.…”

“…Thus, the frequency of the presence of limonene and linalool in everyday products adds to the risk of being sensitized, as a person will be potentially in contact with these compounds from many sources in the course of one day. Although the actual concentrations of limonene and linalool and their oxidized products used in different consumer products are commonly unknown , it has been shown that, with repeated exposure to these fragrance terpenes, low concentrations may be sufficient to elicit or worsen eczema in previously sensitized individuals . Therefore, allergic patients may be at continuous risk of developing contact dermatitis, owing to the ubiquity of these compounds in common products.…”

Encapsulation of clove essential oil in hydroxypropyl beta-cyclodextrin for characterization, controlled release, and antioxidant activity

“…Degradation of compounds can cause some undesirable modifications in foods like color changes and producing off‐flavor components (Lucera, Mastromatteo, Sinigaglia, & Corbo, ; Paradiso, Summo, Pasqualone, & Caponio, ; Tinchan, Lorjaroenphon, Cadwallader, & Chaiseri, ). Moreover, allergenic effects of air‐oxidized fragrance terpenes have been reported (Christensson et al, ; Hagvall, Berglund, & Christensson, ).…”

Cosmetic Habits and Cosmetic Contact Dermatitis in Children

“…Their hydroperoxides are strong allergens [7,8]. Occasionally, cross-reactions are seen to botanically derived materials, such as plants from the Compositae family, due to the common presence of oxidized terpenes [9] (cf.…”