Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC^* prospective study

Abstract

Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.

Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study

“…In recent years, Lim‐OOHs present in oxidized limonene have emerged as a very frequent cause of contact allergy in consecutively patch tested dermatitis patients . However, high proportions of weak positive and doubtful reactions have caused some concern regarding the clinical relevance of a positive patch test reaction .…”

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

“…In Spain 3639 patients were recently tested with three different concentrations of limonene, limonene hydroperoxides and linalool hydroperoxides. The results showed that 292 were patch positive to one or both hydroperoxides and 187 of them (5.1%) developed positive patch reaction to limonene hydroperoxides [106].…”

The European baseline series and recommended additions: 2019

“…and limonene hydroperoxide 0.3% and 0.2% pet. have been widely tested and shown to produce frequent positive reactions, leading to recommendations to include them in some national series . It was highlighted that frequent irritant and doubtful patch test reactions to these haptens have been observed, and that, to aid in interpretation, two dilutions of each should be tested if these haptens are tested routinely.…”

“…It was noted that, whereas exposure to linalool or limonene as indicated by product labelling is common, clinical relevance in terms of proven skin contact with presumably sufficient levels of these hydroperoxides in culprit products is less well documented. It was recognized that further improvement in screening for fragrance allergy is required Benzisothiazolinone 0.1% pet.…”