Air pollutants cause release of hydrogen peroxide and interleukin‐8 in a human primary nasal tissue culture model

Cho, Do‐Yeon; Le, Wei; Bravo, Dawn T.; Hwang, Peter H.; Illek, Beate; Fischer, Horst; Nayak, Jayakar V.

doi:10.1002/alr.21413

Cited by 30 publications

(27 citation statements)

References 37 publications

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“…UPM may impair skin barrier function . In vitro, exposure to particulate matter increased IL‐8 levels in, and mucin production by, nasal epithelial cell tissues . In vivo short‐term exposure to UPM increased the levels of IL‐6 and IL‐8 in nasal secretions .…”

Section: Discussionmentioning

confidence: 99%

The effect of urban particulate matter on cultured human nasal fibroblasts

Lee

Choi

et al. 2018

Int Forum Allergy Rhinol

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Section: Discussionmentioning

confidence: 99%

The effect of urban particulate matter on cultured human nasal fibroblasts

Lee

Choi

et al. 2018

Int Forum Allergy Rhinol

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“…4). It stimulates cellular reactive oxygen (ROS) production (Bedard et al, 2007;Lassegue and Griendling, 2010;Cho et al, 2014) and the expression of inflammatory cytokines such as TNF-α and IL-1 (Fujii et al, 2002;Bengalli et al, 2013). As shown in Fig.…”

Section: E Cava Is a Brown Alga Found In The Coastal Area Of Koreamentioning

confidence: 99%

Effect of Mixture Composed of Jeju' Scoria and Ecklonia cava on Anti-inflammation

Kang

2018

BSL

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The purpose of this study is to investigate the anti-inflammation effect of the mixture, consisting of a series of different ratio of Ecklonia cava extract and scoria. Also, to make more functional scoria powder into cosmetic material, studies on the toxicity by cell viability assay. Scoria is found in large amounts in Jeju Island, as an adsorbent of heavy metal ions (Ni 2 +, Zn 2 +, and Cr 3 +) in an aspect of its efficient utilization. Marine plants such as Ecklonia cava contain high amounts of polyphenolic antioxidants. The purpose of this study was to examine the anti-oxidative and anti-inflammation effects of combination of mixture of Eckloina cava extrat and scoria with optimal ratio. Therefore, this study suggested that combination of mixture of Eckloina cava extrat and scoria and its attenuated the oxidative and inflammatory reactions.

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“…PM10 causes the production of reactive oxygen species (ROS) by NADPH oxidases (NOXs) [11-13] and stimulates alveolar macrophages and airway epithelial cells to produce proinflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β [14, 15]. PM10 also induces the gene expression and activation of matrix metalloproteinases (MMPs) involved in the degradation of extracellular matrix components, including collagen [16].…”

Section: Introductionmentioning

confidence: 99%

Punicalagin and (–)-Epigallocatechin-3-Gallate Rescue Cell Viability and Attenuate Inflammatory Responses of Human Epidermal Keratinocytes Exposed to Airborne Particulate Matter PM10

Seok

Lee

Kim³

et al. 2018

Skin Pharmacol Physiol

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Background/Aims: Airborne particulate matter with a diameter of < 10 µm (PM10) causes oxidative damage, inflammation, and premature skin aging. In this study, we evaluated whether polyphenolic antioxidants attenuate the inflammatory responses of PM10-exposed keratinocytes. Methods: Primary human epidermal keratinocytes were exposed in vitro to PM10 in the absence or presence of punicalagin and (–)-epigallocatechin-3-gallate (EGCG), which are the major polyphenolic antioxidants found in pomegranate and green tea, respectively. Assays were performed to determine cell viability, production of reactive oxygen species (ROS), and expression of NADPH oxidases (NOX), proinflammatory cytokines, and matrix metalloproteinase (MMP)-1. Results: PM10 decreased cell viability and increased ROS production in a dose-dependent manner. It also increased the expression levels of NOX-1, NOX-2, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, and MMP-1. Punicalagin was not cytotoxic up to 300 μM, and (–)-EGCG was cytotoxic above 30 μM, respectively. Further, punicalagin (3–30 μM) and EGCG (3–10 μM) rescued the viability of PM10-exposed cells. They also attenuated ROS production and the expression of NOX-1, NOX-2, TNF-α, IL-1β, IL-6, IL-8, and MMP-1 stimulated by PM10. Conclusions: This study demonstrates that polyphenolic antioxidants, such as punicalagin and (–)-EGCG, rescue keratinocyte viability and attenuate the inflammatory responses of these cells due to airborne particles.

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Air pollutants cause release of hydrogen peroxide and interleukin‐8 in a human primary nasal tissue culture model

Cited by 30 publications

References 37 publications

The effect of urban particulate matter on cultured human nasal fibroblasts

The effect of urban particulate matter on cultured human nasal fibroblasts

Effect of Mixture Composed of Jeju' Scoria and Ecklonia cava on Anti-inflammation

Punicalagin and (–)-Epigallocatechin-3-Gallate Rescue Cell Viability and Attenuate Inflammatory Responses of Human Epidermal Keratinocytes Exposed to Airborne Particulate Matter PM10

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