Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury

Ghio, Andrew J.; Soukup, Joleen M.; Dailey, Lisa A.; Madden, Michael C.

doi:10.1016/j.freeradbiomed.2020.02.007

Cited by 26 publications

(23 citation statements)

References 328 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, a single pathway has been proposed through which the effects of all particles are generated. 1,2 Inorganic particles including oxides and oxide minerals have oxygen-containing functional groups at their surface such as silanols (-Si-OH) in silica and silicate particles. The inhalation of particles with such surfaces comprised of oxygen-containing functional groups introduces an electronegative interface following their deprotonation at physiologic pH values.…”

Section: Introductionmentioning

confidence: 99%

“…Following exposure, organic particles also complex metal available in cells and tissues via these surface functional groups. 2 Humic substances (HS) are heterogeneous, amorphous, organic materials found in all terrestrial and aqueous environments. Three different fractions of HS exist: humic acid, fulvic acid, and humin.…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, a single pathway has been proposed through which the effects of all particles are generated. 1,2…”

Section: Introductionmentioning

confidence: 99%

“…Following exposure, organic particles also complex metal available in cells and tissues via these surface functional groups. 2…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect

et al. 2020

Self Cite

View full text Add to dashboard Cite

Exposure to ambient ozone has been associated with increased human mortality. Ozone exposure can introduce oxygen-containing functional groups in particulate matter (PM) effecting a greater capacity of the particle for metal complexation and inflammatory effect. We tested the postulate that (1) a fulvic acid-like substance can be produced through a reaction of a carbonaceous particle with high concentrations of ozone and (2) such a fulvic acid-like substance included in the PM can initiate inflammatory effects following exposure of respiratory epithelial (BEAS-2B) cells and an animal model (male Wistar Kyoto rats). Carbon black (CB) was exposed for 72 hours to either filtered air (CB-Air) or approximately 100 ppm ozone (CB-O3). Carbon black exposure to high levels of ozone produced water-soluble, fluorescent organic material. Iron import by BEAS-2B cells at 4 and 24 hours was not induced by incubations with CB-Air but was increased following coexposures of CB-O3 with ferric ammonium citrate. In contrast to CB-Air, exposure of BEAS-2B cells and rats to CB-O3 for 24 hours increased expression of pro-inflammatory cytokines and lung injury, respectively. It is concluded that inflammatory effects of carbonaceous particles on cells can potentially result from (1) an inclusion of a fulvic acid-like substance after reaction with ozone and (2) changes in iron homeostasis following such exposure.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…[29]) or can be metabolised to reactive electrophiles in vivo (PAHs). In addition, non-redox active components can trigger inflammation (LPS) or activate kinase stress pathways by inactivation of phosphatases (exemplified by Zn), even interfere with mitochondrial function (as reviewed by Samet in the current issue [30]) and molecules introduced into the lung on the surface of particles can act as metal chelators, disrupting normal iron homeostasis (Ghio's review article [31]).…”

mentioning

confidence: 99%

Oxidative stress in air pollution research

Mudway

Kelly

Holgate

2020

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers

Sauvain,

Hemmendinger,

Charreau

et al. 2024

Int Arch Occup Environ Health

View full text Add to dashboard Cite

Objective In this pilot study on subway workers, we explored the relationships between particle exposure and oxidative stress biomarkers in exhaled breath condensate (EBC) and urine to identify the most relevant biomarkers for a large-scale study in this field. Methods We constructed a comprehensive occupational exposure assessment among subway workers in three distinct jobs over 10 working days, measuring daily concentrations of particulate matter (PM), their metal content and oxidative potential (OP). Individual pre- and post-shift EBC and urine samples were collected daily. Three oxidative stress biomarkers were measured in these matrices: malondialdehyde (MDA), 8-hydroxy-2′deoxyguanosine (8-OHdG) and 8-isoprostane. The association between each effect biomarker and exposure variables was estimated by multivariable multilevel mixed-effect models with and without lag times. Results The OP was positively associated with Fe and Mn, but not associated with any effect biomarkers. Concentration changes of effect biomarkers in EBC and urine were associated with transition metals in PM (Cu and Zn) and furthermore with specific metals in EBC (Ba, Co, Cr and Mn) and in urine (Ba, Cu, Co, Mo, Ni, Ti and Zn). The direction of these associations was both metal- and time-dependent. Associations between Cu or Zn and MDAEBC generally reached statistical significance after a delayed time of 12 or 24 h after exposure. Changes in metal concentrations in EBC and urine were associated with MDA and 8-OHdG concentrations the same day. Conclusion Associations between MDA in both EBC and urine gave opposite response for subway particles containing Zn versus Cu. This diverting Zn and Cu pattern was also observed for 8-OHdG and urinary concentrations of these two metals. Overall, MDA and 8-OHdG responses were sensitive for same-day metal exposures in both matrices. We recommend MDA and 8-OHdG in large field studies to account for oxidative stress originating from metals in inhaled particulate matter.

show abstract

Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury

Cited by 26 publications

References 328 publications

Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect

Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect

Oxidative stress in air pollution research

Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers

Contact Info

Product

Resources

About