Air pollution and children’s respiratory health: a scoping review of socioeconomic status as an effect modifier

Muñoz-Pizza, Dalia M.; Villada-Canela, Mariana; Reyna, Marco A.; Texcalac-Sangrador, José Luis; Osornio-Vargas, Álvaro

doi:10.1007/s00038-020-01378-3

Cited by 28 publications

(9 citation statements)

References 56 publications

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“…Third, we examined the combined (interactive) effects of school disadvantage and air pollution exposures on proficiency in math and ELA. Time-series air pollution epidemiology studies have examined how social factors modify the effects of pollution on health [39]. However, school-based studies on air pollution and academic proficiency have not, which highlights the relevance of our third question: does school disadvantage modify the effects of chronic PM 2.5 exposures and/or the frequency of peak PM 2.5 exposures on proficiency in math and ELA?…”

Section: Children's Differential Sensitivity To Air Pollutionmentioning

confidence: 99%

“…While those studies have paradoxically found that residents in less exposed/wealthier/Whiter areas are more sensitive to the health effects of air pollution than residents in more highly exposed/poorer/minority areas, others have found the opposite. Some have found that racial/ethnic minority and low-income people are more sensitive to the health effects of air pollution than are White and more affluent people [39][40][41][42][43]. For example, in Phoenix, children without insurance (i.e., low-income children) had a 1.4 times higher risk of asthma admissions than those with private insurance (i.e., higher income children) when levels of NO 2 were high [44].…”

Section: Children's Differential Sensitivity To Air Pollutionmentioning

confidence: 99%

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Effects of PM2.5 on Third Grade Students’ Proficiency in Math and English Language Arts

Mullen

Grineski

Collins

et al. 2020

IJERPH

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Fine particulate air pollution is harmful to children in myriad ways. While evidence is mounting that chronic exposures are associated with reduced academic proficiency, no research has examined the frequency of peak exposures. It is also unknown if pollution exposures influence academic proficiency to the same degree in all schools or if the level of children’s social disadvantage in schools modifies the effects, such that some schools’ academic proficiency levels are more sensitive to exposures. We address these gaps by examining the percentage of third grade students who tested below the grade level in math and English language arts (ELA) in Salt Lake County, Utah primary schools (n = 156), where fine particulate pollution is a serious health threat. More frequent peak exposures were associated with reduced math and ELA proficiency, as was greater school disadvantage. High frequency peak exposures were more strongly linked to lower math proficiency in more advantaged schools. Findings highlight the need for policies to reduce the number of days with peak air pollution.

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Section: Children's Differential Sensitivity To Air Pollutionmentioning

confidence: 99%

Section: Children's Differential Sensitivity To Air Pollutionmentioning

confidence: 99%

Effects of PM2.5 on Third Grade Students’ Proficiency in Math and English Language Arts

Mullen

Grineski

Collins

et al. 2020

IJERPH

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“…Numerous studies have identified corresponding burdens of cancer, respiratory disease, or premature death (e.g. [12][13][14]), but less is known about how racial disparities in pollution exposure affect reproductive health. Such knowledge is critical to advancing health equity, given that adverse maternal and infant health outcomes disproportionately affect historically marginalized populations, particularly black women in the U.S [15,16].…”

Section: Introductionmentioning

confidence: 99%

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana ^*

Terrell,

St Julien,

Wallace

2024

Environ. Res.: Health

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Previous studies indicate that pollution exposure can increase risks of adverse birth outcomes, but Black communities are underrepresented in this research, and the potential moderating role of neighborhood context has not been explored. These issues are especially relevant in Louisiana, which has a high proportion of Black residents, an entrenched history of structural racism, the most pounds of toxic industrial emissions annually, and among the nation’s highest rates of low birthweight (LBW), preterm birth (PTB), and infant mortality. We investigated whether air pollution and social polarization by race and income (measured via the index of concentration at the extremes [ICE]) were associated with LBW and PTB among Louisiana census tracts (n = 1,101) using spatial lag models. Data sources included 2011-2020 birth records, U.S. Census Bureau 2017 demographic data, and 2017 Respiratory Hazard (RH) from the U.S. Environmental Protection Agency. Both RH and ICE were associated with LBW (z = 4.4, P < 0.0001; z = -27.0, P < 0.0001) and PTB (z = 2.3, P = 0.019; z = -16.7, P < 0.0001), with no interaction. Severely polluted tracts had 25% higher and 36% higher risks of LBW and PTB, respectively, versus unpolluted tracts. On average, 2,166 low birthweight and 3,583 preterm births annually were attributable to pollution exposure. Tracts with concentrated social deprivation (i.e. low ICE scores) had 53% higher and 34% higher risks of LBW and PTB, respectively, versus intermediate or mixed tracts. On average, 1,171 low birthweight and 1,739 preterm births annually were attributable to concentrated deprivation. Our ecological study found that a majority of adverse birth outcomes in Louisiana (i.e. 67% of LBW and PTB combined) are linked to air pollution exposure or disadvantage resulting from social polarization. These findings can inform research, policy, and advocacy to improve health equity in marginalized communities.

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“…Environmental risk factors disproportionally affect socioeconomically disadvantaged children, particularly those living in urban environments [47,48]. In fact, socioeconomic effects contribute to disparities in lung health [49], including the higher burden of chronic respiratory disease among Black and Hispanic children compared to non-Hispanic white children [49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

et al. 2023

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Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those most relevant to pediatric populations and populations of different ancestries. In this study, we performed genome-wide association analyses of lung function in a multiethnic cohort of children (n = 1,035) living in low-income urban neighborhoods. We identified one novel locus at the TDRD9 gene in chromosome 14q32.33 associated with percent predicted forced expiratory volume in one second (FEV1) (p = 2.4x10-9; βz = -0.31, 95% CI = -0.41- -0.21). Mendelian randomization and mediation analyses revealed that this genetic effect on FEV1 was partially mediated by DNA methylation levels at this locus in airway epithelial cells, which were also associated with environmental tobacco smoke exposure (p = 0.015). Promoter-enhancer interactions in airway epithelial cells revealed chromatin interaction loops between FEV1-associated variants in TDRD9 and the promoter region of the PPP1R13B gene, a stimulator of p53-mediated apoptosis. Expression of PPP1R13B in airway epithelial cells was significantly associated the FEV1 risk alleles (p = 1.3x10-5; β = 0.12, 95% CI = 0.06–0.17). These combined results highlight a potential novel mechanism for reduced lung function in urban youth resulting from both genetics and smoking exposure.

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Air pollution and children’s respiratory health: a scoping review of socioeconomic status as an effect modifier

Cited by 28 publications

References 56 publications

Effects of PM2.5 on Third Grade Students’ Proficiency in Math and English Language Arts

Effects of PM2.5 on Third Grade Students’ Proficiency in Math and English Language Arts

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana ^*

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

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Air pollution and children’s respiratory health: a scoping review of socioeconomic status as an effect modifier

Cited by 28 publications

References 56 publications

Effects of PM2.5 on Third Grade Students’ Proficiency in Math and English Language Arts

Effects of PM2.5 on Third Grade Students’ Proficiency in Math and English Language Arts

Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana *

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

Contact Info

Product

Resources

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Toxic air pollution and concentrated social deprivation are associated with low birthweight and preterm Birth in Louisiana ^*