Air pollution exposure and preeclampsia among US women with and without asthma

Mendola, Pauline; Wallace, Maeve; Liu, Danping; Robledo, Candace; Männistö, Tuija; Grantz, Katherine L.

doi:10.1016/j.envres.2016.04.004

Cited by 43 publications

(39 citation statements)

References 28 publications

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“…Indeed, similar to findings by Savitz et al (26), we previously demonstrated overall null associations between exposures to air pollutants during early gestation and risk of preeclampsia among nonasthmatic women (27) as opposed to findings on GH in the current study. However, among the 17 studies included in a recent meta-analysis on air pollution in relation to pregnancy-induced hypertensive disorders (10), only 3 treated GH separately (12)(13)(14).…”

Section: Discussionsupporting

confidence: 50%

Ambient Air Pollution and Risk of Gestational Hypertension

Zhu¹,

Zhang²,

Liu³

et al. 2017

American Journal of Epidemiology

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Air pollution has been linked to hypertension in the general population, but data on gestational hypertension (GH) are limited. We investigated criteria air pollutants and air toxics during the period before conception and in early gestation in relation to GH risk in the Consortium on Safe Labor/Air Quality and Reproductive Health Study (United States, 2002. Modified Community Multi-scale Air Quality models estimated air pollution exposures for 6,074 singleton pregnancies in which GH was present and 199,980 normotensive pregnancies. Generalized estimating equations estimated relative risks per interquartile-range increment for pollutants and high exposure (≥75th percentile) for air toxics after adjustment for major risk factors. For an interquartile-range increment, GH risk was significantly increased by 18% for sulfur dioxide during the 3 months before conception and, during gestational weeks 1-20, 17% for nitrogen oxides, 10% for particulate matter with an aerodynamic diameter <2.5 μm, 7% for particulate matter with an aerodynamic diameter <10 μm, and 22% for sulfur dioxide. High exposures to several polycyclic aromatic hydrocarbons before conception and during the first trimester were significantly associated with 8%-20% higher risk of GH. Further, preconceptional exposures to several volatile organic compounds were significantly associated with 11%-19% higher risk. Our findings suggest that early exposures to criteria air pollutants, particularly from transport emissions, and high exposure to several air toxics before conception may increase GH risk.

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Section: Discussionsupporting

confidence: 50%

Ambient Air Pollution and Risk of Gestational Hypertension

Zhu¹,

Zhang²,

Liu³

et al. 2017

American Journal of Epidemiology

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“…Other studies stratified by various BMI categories. Analyses restricted by BMI (stratified on pre‐pregnancy BMI ≥25 kg/m 2 only and BMI ≥30 kg/m 2 ) generally yielded similar results as the main analyses, although with a loss of precision due to the smaller sample (Mendola et al, ). Rudra et al () reported no differences in models stratified by BMI status in their finding of no association of PM 2.5 with either preterm delivery or preeclampsia.…”

Section: Resultsmentioning

confidence: 59%

“…Similarly, the literature provides evidence for a combined effect of a single air pollutant and a pre‐existing chronic condition on maternal health, but the data are limited in scope. No evidence of an increase in risk of preeclampsia with increases in PM exposure was observed in a test of interaction by maternal asthmatic status (Mendola et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…One study discussed mediation of blood pressure increases (Lee et al, 2013). Three studies directly assessed interactions (Mendola et al, 2016;Mobasher et al, 2013;Vinikoor-Imler et al, 2012), and the other studies largely performed stratifications to assess confounders, reporting few differences by category ( Table 5). All studies assumed that the exposure period for social factors was the same as for pollutants.…”

Section: Combined Association Of Air Pollution and Social Stressors Omentioning

confidence: 99%

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Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining “At‐Risk” Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy

Koman¹,

Hogan²,

Sampson³

et al. 2018

World Med & Health Policy

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Pregnant women are uniquely susceptible to adverse effects of air pollution exposure due to vulnerabilities and health consequences during pregnancy (e.g., hypertensive disorders of pregnancy [HDP]) compared to the general population. Because the Clean Air Act (CAA) creates a duty to protect at-risk groups, the regulatory assessment of at-risk populations has both policy and scientific foundations. Previously, pregnant women have not been specially protected in establishing the margin of safety for the ozone and particulate matter (PM) standards. Due to physiological changes, pregnant women can be at greater risk of adverse effects of air pollution and should be considered an at-risk population. Women with preexisting conditions, women experiencing poverty, and groups that suffer systematic discrimination may be particularly susceptible to cardiac effects of air pollutants during pregnancy. We rigorously reviewed 11 studies of over 1.3 million pregnant women in the United States to characterize the relationship between ozone or PM exposure and HDP. Findings were generally mixed, with a few studies reporting a joint association between ozone or PM and social determinants or pre-existing chronic health conditions related to HDP. Adequate evidence associates exposure to PM with an adverse effect of HDP among pregnant women not evident among non-gravid populations.

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“…The consequences of these effects (e.g., preeclampsia or intrauterine growth restriction) have been suggested in air monitoring studies but deserve further exploration in studies with urinary biomarkers of exposure. 9, 41 …”

Section: Discussionmentioning

confidence: 99%

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Ferguson

McElrath

Pace

et al. 2017

Environ. Sci. Technol.

104

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Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is prevalent and may adversely impact pregnancy and development of the fetus. The purpose of this exploratory study was to examine urinary PAH metabolites in association with mediators of these outcomes. To do so we measured a panel of 12 inflammatory, angiogenic, and oxidative stress biomarkers in plasma or urine from women in their third trimester of pregnancy (n=200). Urinary PAH metabolites were highly detectable (>88%) in the study population, and most were higher in women who had lower education levels, higher body mass index, and who were African American. Some PAH metabolites showed consistent positive associations with the plasma inflammation marker C-reactive protein (CRP) and the urinary oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. For example, an interquartile range increase in 2-hydroxynapthalene was associated with a 35% increase in CRP (95% confidence interval = −0.13, 83.2), a 14% increase in 8-OHdG (95% confidence interval = 0.59, 30.1), and a 48% increase in 8-isoprostane (95% confidence interval = 16.7, 87.0). These data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adverse pregnancy or developmental outcomes; however, these results should be corroborated in a larger study population.

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Air pollution exposure and preeclampsia among US women with and without asthma

Cited by 43 publications

References 28 publications

Ambient Air Pollution and Risk of Gestational Hypertension

Ambient Air Pollution and Risk of Gestational Hypertension

Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining “At‐Risk” Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

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