Air pollution-induced missed abortion risk for pregnancies

Zhang, Liqiang; Liu, Weiwei; Hou, Kun Mean; Lin, Jintai; Zhou, Chenghu; Tong, Xiaohua; Wang, Ziye; Wang, Yuebin; Jiang, Yanxiao; Wang, Ziwei; Zheng, Yibo; Lan, Yonglian; Liu, Suhong; Ni, Ruijing; Liu, Mengyao; Zhu, Peisheng

doi:10.1038/s41893-019-0387-y

Cited by 64 publications

(45 citation statements)

References 44 publications

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“…Recent studies have uncovered a positive association between pollution and spontaneous abortion ( Leiser et al, 2019 ; Zhang et al, 2019 ), so our analyses presented here allow for more specific hypotheses regarding the potential chemicals that might cause preferential abortions of male or female fetuses. Fortunately, most of the putative positive associations identi1ed in our study are experimentally testable, at least with animal models.…”

Section: Discussionmentioning

confidence: 99%

“…, terrorist attacks and earthquakes), radiation, weather parameters, and even seasons of conception (Table 1). While there are multiple studies in which the positive associations between air pollution and spontaneous abortion have been observed ( Leiser et al, 2019 ; Zhang et al, 2019 ), most of those conclusions were drawn based on analyses of relatively small samples (Table 1). In this study, we harnessed the power of two very large datasets: MarketScan’s insurance claim data ( Hansen, 2017 ) in the United States (more than 100 million unique patients and more than three million unique newborns recorded between 2003 to 2011), and Sweden’s birth registry data (∼ 3.2 million newborns from 1983 to 2013) ( Emilsson et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Mythical and Observable Trends in Human Sex Ratio at Birth

Rzhetsky

Long

Chen

et al. 2020

Preprint

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The human sex ratio at birth (SRB) is defined as the ratio between the number of 11 newborn boys to the total number of newborns per time unit. It is, typically, slightly greater than 1 2 12 (more boys than girls) and fluctuates over time. In this study, we sought to "myth-check" previously 13 reported associations (and test new hypotheses) using variants of mixed-effect regression analyses 14 and time-series models on two very large electronic health record datasets, representing the 15 populations in the United States and Sweden, respectively. Our results revealed that neither 16 dataset supported models in which the SRB changed seasonally or in response to variations in 17 ambient temperature, and that an increased level of a diverse array of pollutants were associated 18 with lower SRBs. Moreover, we found that increased levels of industrial and agricultural activity, 19 which served as proxies for water pollution, were also associated with lower SRBs. 20 21 42 215 We are grateful to E. Gannon and M. Rzhetsky for comments on earlier versions of this manuscript. References 221 Benjamini Y, Yekutieli D, et al. The control of the false discovery rate in multiple testing under dependency. The 222 annals of statistics. 2001; 29(4):1165-1188. 223 Box GE, Jenkins GM, Reinsel GC, Ljung GM. Time series analysis: forecasting and control. John Wiley & Sons; 224 2015. 225 Breusch TS. Testing for autocorrelation in dynamic linear models. Australian Economic Papers. 1978; 17(31):334-226 355. 227 Brodersen KH, Gallusser F, Koehler J, Remy N, Scott SL, et al. Inferring causal impact using Bayesian structural 228 time-series models. The Annals of Applied Statistics. 2015; 9(1):247-274. 229 Bruckner TA, Catalano R. Selection in utero and population health: theory and typology of research. SSM-230 population health. 2018; 5:101-113. 231 Bürkner PC. brms: An R package for Bayesian multilevel models using STAN. Journal of Statistical Software. 232 2017; 80(1):1-28. 233 Catalano R, Bruckner T, Smith KR. Ambient temperature predicts sex ratios and male longevity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mythical and Observable Trends in Human Sex Ratio at Birth

Rzhetsky

Long

Chen

et al. 2020

Preprint

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“…Regarding environmental public health, many modern disease risks are linked to a mismatch between the environment we evolved under and the one we have created, through both direct and indirect effects on human health. Air pollution is associated with increased risks of respiratory tract infections and cardiovascular disease [24,25] and has also been shown to be associated with preterm birth and early miscarriage [26,27]. The One Health concept integrates the essential connections between human health and disease and both animal and environmental health [28].…”

Section: Evolution Public Health and The One Health Conceptmentioning

confidence: 99%

Integrating evolution into medical education for women’s health care practitioners

Power

Snead

Reed

et al. 2020

Evolution, Medicine, and Public Health

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Evolution is a fundamental principle in biology; however, it has been neglected in medical education.We argue that an evolutionary perspective is especially important for women's health care providers, as selection will act strongly on reproductive parameters, and the biological costs of female reproduction are generally more resource expensive than for men (e.g. due to gestation and lactation) with greater effects on health and wellbeing. An evolutionary perspective is needed to understand antibiotic resistance, disease and health risks associated with mismatches between our evolved adaptations and current conditions, the importance of the microbiome and the maternal role in how infants acquire and develop their early-life microbiome (vaginal birth, lactation), and the importance of breastmilk as a biochemical signal from mothers to their babies. We present data that obstetrician-gynecologists' views regarding the inclusion of evolution within their training is generally positive, but many barriers are perceived. Requiring coursework in evolutionary biology with an emphasis on evolutionary medicine prior to enrollment in medical school may be a solution. K E Y W O R D S : lactation; microbiome; medical training; obstetrician-gynecologists E. Mayr, 1982 [1] V C The Author(s)

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“…Zhang and colleagues examined the records of 255,668 pregnant women from 2009 to 2017 in Beijing, China, and quanti ed the link between CO exposure and SAB risk. They found long-term exposure to CO before pregnancy was associated with signi cant increased risk of SAB [17]. Inconsistent results may mainly be ascribed to different study designs and exposure ranges.…”

Section: Sabmentioning

confidence: 99%

“…At least 25% of all women experience one or more sporadic miscarriages [10]. Detrimental effects of air pollution on SAB have been previously suggested with exposure to particulate matter (PM) and some gaseous pollutants [11. Most of the previous studies reported strong associations of high PM [12][13][14][15], sulfur dioxide (SO 2 ) [16,17] and ozone (O 3 ) [12,15,18] exposure with increased risk of SAB. However, evidence regarding nitrogen dioxide (NO 2 ) and carbon monoxide (CO) are insu cient and less inclusive, suggesting more studies are warranted to better understand their associations with SAB risk [11].…”

Section: Introductionmentioning

confidence: 99%

Nitrogen dioxide exposure during pregnancy and risk of spontaneous abortion: a case-control study in China

Wang

Hong

Sheng

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

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Background Evidence on the relationship between prenatal exposure to NO 2 and CO and spontaneous abortion (SAB) is insu cient. We investigated whether there is an association between maternal exposure to nitrogen dioxide (NO 2) and carbon monoxide (CO) before and during pregnancy and SAB. Methods We conducted a case-control study using medical records of 2445 pregnant women who admitted for abortion prior to 20 weeks of gestational age from January 2014 to December 2019 at a tertiary-care hospital in Shanghai, China. Of the 2445 participants, 1075 were SAB cases and 1370 were healthy controls (underwent elective abortions). Maternal exposure to NO 2 and CO before and during pregnancy was estimated using daily air pollution concentration data. Multivariable logistic regression models were constructed to quantify the relationships between maternal exposure to NO 2 or CO and the risk of SAB while controlling for potential confounders. Results NO 2 exposure levels during pregnancy were signi cantly higher in SAB cases than in healthy controls (42.26 vs 40.67, P < 0.01). NO 2 exposure during pregnancy was positively associated with the risk of SAB. An interquartile range (16 µg/m 3) increase in NO 2 exposure was associated with 67% increase in the odds of SAB (OR = 1.67, 95% CI, 1.28, 2.18). Analyses of associations by quartile of NO 2 exposure showed that elevated NO 2 exposure during pregnancy was associated with increased odds of SAB in linear doseresponse manners. Compared with the lowest quartile of NO 2 exposure, the odds of SAB in the fourth quartile of NO 2 exposure increased 60% (OR = 1.60, 95% CI, 1.03-2.49). No associations of CO exposure with SAB risk were observed. Conclusion Our study suggested that exposure to NO 2 during early pregnancy was associated with increased risk of SAB. Further studies are need to con rm our results and explore the potential biological mechanism underlying these associations.

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Air pollution-induced missed abortion risk for pregnancies

Cited by 64 publications

References 44 publications

Mythical and Observable Trends in Human Sex Ratio at Birth

Mythical and Observable Trends in Human Sex Ratio at Birth

Integrating evolution into medical education for women’s health care practitioners

Nitrogen dioxide exposure during pregnancy and risk of spontaneous abortion: a case-control study in China

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