Air Trapping in Primary Sjögren Syndrome: Correlation of Expiratory CT with Pulmonary Function Tests

Franquet, Tomás; Díaz, César; Domingo, Pere; Giménez, A.; Geli, C.

doi:10.1097/00004728-199903000-00002

Cited by 54 publications

(24 citation statements)

References 15 publications

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“…Other authors reported a mixed ventilatory defect [41] or a relatively high frequency of small airways obstruction [4]. In another study [34] all the patients with findings of air trapping on thin-section CT scans had normal PFT results, and the extent of air trapping did not correlate with PFT. The authors of that study concluded that air trapping can be an early marker of disease, and may develop earlier than impairment of lung function.…”

Section: Discussionmentioning

confidence: 88%

“…6a, b Transverse thin-section CT scans of the lungs from a 76-year-old woman with PSS and ILF shows diffuse ground-glass attenuation with multiple randomly distributed thin-walled lung cysts. Mild septal and intralobular thickening is also present The results are expressed as percentages of the normal predicted values (mean±SD) The 2 patients with normal scans and the 2 patients with findings or images suggestive of pulmonary hypertension were excluded PSS patients [5,10,34], leading to an increased risk of recurrent respiratory tract infections in association with tracheal and bronchial dryness [4,35], Airway disease is defined as bronchial wall thickening and/or bronchiectasis when the large airways are involved and findings of cellular and constrictive bronchiolitis when the small airways are affected [36]. Franquet et al reported CT abnormalities of the small airways in 11 of 34 (32%) of patients [34].…”

Section: Pft-ct Findings Correlationmentioning

confidence: 99%

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Thin-section chest CT findings of primary Sjögren's syndrome: correlation with pulmonary function

et al. 2001

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The purpose of this study was to describe thin-section CT findings of lung involvement in patients with primary Sjögren's syndrome (PSS), and to correlate them with pulmonary function tests (PFT). The chest thin-section CT examinations of 35 patients with proven diagnosis of PSS and respiratory symptoms were retrospectively assessed by two observers, in a first step independently with interobserver evaluation, and in a second step in consensus. The extent of the most frequent CT findings was scored. Correlation was made with PFT in 31 of these patients. Three main CT patterns were identified with good interobserver agreement (kappa coefficient 0.71): 19 of 35 (54%) large and/or small airways disease; 7 of 35 (20%) interstitial lung fibrosis (ILF); and 5 of 35 (14%) suggestive of lymphocytic interstitial pneumonia (LIP). The CT scans were normal in 2 patients (6%) and showed only dilatation of pulmonary vessels due to pulmonary arterial hypertension in two others (6%). Airway disease patients had predominantly obstructive profiles (mean FEV(1)/FVC ratio 69.7+/-12.7%, mean MEF(25) 50.1+/-22.9%), whereas patients with ILF and LIP had predominantly restrictive profiles and/or a decreased diffusing lung capacity (mean TLC 87.0+/-26.0 and 64.6+/-18.6%, mean DL(CO) 57.4+/-21.2 and 52.0+/-8.0%). Significant correlation ( p<0.01) was found between the scores of ground-glass attenuation and TLC ( r=-0.84) and DL(CO) ( r=-0.70) and between the score of air trapping and FEV1 ( r=-1.0). In patients with PSS and respiratory symptoms, thin-section CT may provide characterization of lung involvement which correlates with pulmonary function.

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Section: Discussionmentioning

confidence: 88%

Section: Pft-ct Findings Correlationmentioning

confidence: 99%

Thin-section chest CT findings of primary Sjögren's syndrome: correlation with pulmonary function

et al. 2001

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“…Both follicular bronchiolitis and constrictive bronchiolitis may be encountered in subjects with connective tissue diseases and may even coexist in the same patient [41,44]. CT scan findings in Sjö gren's syndrome and in rheumatoid arthritis have been the subject of many studies [44][45][46][47][48][49][50][51][52][53][54], and are characterised by usual signs of small airways abnormalities, including mosaic attenuation on inspiratory CT, air trapping on expiratory CT, ground-glass opacities, and centrilobular nodules eventually with tree-in-bud pattern (especially in cellular bronchiolitis) or distension (especially in constrictive bronchiolitis). CT scans may have better sensitivity than pulmonary function tests in rheumatoid arthritis [52].…”

Section: Connective Tissue Diseasesmentioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

Eur Respir Rev

105

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This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.

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“…In patients with both pSS and pSS, 22% had chest radiography abnormalities, with linear and reticular opacities being the most frequent finding [15]. HRCT findings in SS include both interstitial and airway abnormalities and both ILD and bronchiolar inflammatory changes are common abnormal findings seen in pSS [15,34,35,54]. Koyama et al reviewed chest HRCT findings of 60 patients with pSS and showed that the most common findings were ground-glass opacities (92%), centrilobular nodules (78%), nonseptal linear opacities (75%), interlobular septal thickening (55%), bronchiectasis (38%), and cysts (30%) [35].…”

Section: Radiological Featuresmentioning

confidence: 99%