Pulmonary manifestations of Sjögren's syndrome

Chest HRCT findings in patients with primary Sjögren’s syndrome

“…14 Hyperglobulinemia was often observed in patients with pulmonary involvement in pSS, which was not confirmed in our study. 11 Unlike our results, the risk of airway involvement increased with male gender, older age at the time of diagnosis and in smokers. 10 Factors such as older age and longer duration of pSS may be associated with bad prognosis but this was not confirmed in our study.…”

“…Respiratory manifestations in pSS are heterogeneous and may include: dry cough, diffuse panbronchiolitis (DPB), bronchiectasis, nonspecific interstitial pneumonia (NSIP), idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), lung cysts, nodular opacities, follicular bronchiolitis, lymphoid interstitial pneumonia (LIP), pseudolymphoma, lymphomatoid granulomatosis, lymphoma (usually of mucosaassociated lymphoid tissue type-MALT), pulmonary amyloidosis, pulmonary hypertension and pleural involvement. 11,12 The mediastinal manifestations of pSS include lymphadenopathy, thymic lymphoid hyperplasia, multilocular thymic cysts and, rarely, MALT lymphoma. 11,12 Such a wide range of manifestations may lead to significant diagnostic and therapeutic difficulties.…”

“…11,12 The mediastinal manifestations of pSS include lymphadenopathy, thymic lymphoid hyperplasia, multilocular thymic cysts and, rarely, MALT lymphoma. 11,12 Such a wide range of manifestations may lead to significant diagnostic and therapeutic difficulties. Occasionally, a histopathological assessment of lung biopsy is needed.…”

“…In HRCT scans, bronchial wall thickening (8-68%), nodules (6-29%), bronchiectasis (5-46%), air trapping (32%) and ground-glass attenuation were most frequently observed. [11][12][13] According to available publications, the prevalence of respiratory manifestations in pSS is estimated to be about 9-12% and clinical features are present in about 43-75% of patients when radiology imaging such as chest X-ray, HRCT or MRI are performed.…”

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

“…These symptoms result from involvement of the lacrimal and salivary glands. Pulmonary involvement is also common, affecting ≤50% of patients, but it is generally mild [197]. Sjögren's syndrome affects women up to 9 times more often than men [198,199].…”