Airborne house dust particles and diesel exhaust particles as allergen carriers

Ormstad,; Johansen,; Gaarder,

doi:10.1046/j.1365-2222.1998.00302.x

Cited by 101 publications

(66 citation statements)

References 33 publications

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“…PM10 presented a positive trend relationship especially with Aspergillus and Alternaria (Adhikari et al, 2006). PM10 can affect the morphology, allergenicity and aerodynamic attributes of bioaerosols (Adhikari et al, 2006, Ormstad et al, 1998. However, Lin & Li (2000) and Sousa et al, (2008) concluded that there is a non-significant positive correlation between PM10 and Aspergillus or…”

Section: Air Pollutionmentioning

confidence: 85%

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Fayad

2016

Qatar University Life Science Symposium 2016: Biodiversity, Sustainability and Climate Change, With Perspectives From Qatar

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Section: Air Pollutionmentioning

confidence: 85%

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Fayad

2016

Qatar University Life Science Symposium 2016: Biodiversity, Sustainability and Climate Change, With Perspectives From Qatar

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“…Furthermore, a decrease in IFN-γ expression induced by allergen plus DEP injection had also been reported (37). DEP could have the ability to bind allergen and act as carriers of several allergens (38). These findings suggest that DEP have potencies not only to induce airway inflammation by themselves but also to augment the efficacy of antigen presentation (39) by acting as carriers.…”

Section: Discussionmentioning

confidence: 96%

Effect of Diesel Exhaust Particles on House Dust Mite–Induced Airway Eosinophilic Inflammation and Remodeling in Mice

et al. 2010

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Abstract. Recent research has focused on the effects of ambient particulate pollution and much evidence has indicated that particulate pollution is associated with the onset of asthma and allergy; however, the effect of diesel exhaust particles (DEP) on the development of allergen-induced airway remodeling has not been fully investigated in vivo. In the present study, we examined the effects of DEP on Dermatophagoides farinae allergens (Der f)-induced asthma-like phenotypes in mice. Mice were administered i.t. 8 times with Der f. DEP were injected i.t. with Der f 4 times throughout the experiment or twice at the sensitization period. In both cases, DEP aggravated Der f-induced increases in airway responsiveness to acetylcholine, the number of eosinophils and neutrophils in the bronchoalveolar lavage fluid (BALF), serum Der f-specific IgG1 levels, Th2 cytokines and transforming growth factor-β 1 levels in BALF, and amount of hydroxyproline in the right lungs. Furthermore, goblet cell hyperplasia and subepithelial fibrosis were also markedly aggravated. These findings indicate that DEP can potentiate airway remodeling induced by repeated allergen challenge as well as Th2-drived airway hyperresponsiveness, eosinophilic inflammation, and IgG1 production and that DEP can exhibit adjuvant activity for airway remodeling, probably due to the enhancement of allergen sensitization and/or of Th2 polarizing pathways.

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“…On the other hand, we demonstrated that the same levels of macrophages containing MWCNT in both MWCNT and MWCNT+ antigen groups were observed. In addition, the amount of allergen carried on the particles is dependent on the particle surface area 32) and MWCNT share particle characteristics, such as a nano-sized diameter and a large surface area, with ultrafine particles of urban air pollution, 33) suggesting that the large particle surface area of MWCNT is likely to augment the carried amount of allergen and thus the cellular response.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Multiwalled Carbon Nanotubes and Allergen Promotes Early- and Late-Phase Increases in Airway Resistance in Mice

Mizutani

Nabe

Yoshino

2012

Biological & Pharmaceutical Bulletin

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The facilitating effects of multiwalled carbon nanotubes (MWCNT) on allergic asthma have not been sufficiently examined, although MWCNT appear to significantly increase the risk of health problems from occupational or environmental exposure. In this study, we examined whether sensitization by the combination of MWCNT with ovalbumin (OVA) promotes allergic asthmatic responses. BALB/c mice administered vehicle, MWCNT, OVA, or MWCNT OVA through an intranasal route were challenged with OVA intratracheally four times. In the MWCNT OVA group, the fourth challenge caused not only early-but also latephase increases in airway resistance, although these responses were not observed in the vehicle, MWCNT, or OVA group; furthermore, the extents of the early and late responses were comparable to those in mice systemically sensitized with OVA alum. Sensitization with MWCNT and OVA promoted airway inflammation and goblet cell hyperplasia in the lung compared with the vehicle, MWCNT or OVA group. In addition, adjuvant activity for OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a production in serum and increased levels of interleukin-4 (IL-4), IL-5, IL-13, and IL-17 in the lung tissue were observed. In conclusion, these results suggest that exposure to MWCNT and antigen can induce a biphasic increase in airway resistance, airway inflammation, goblet cell hyperplasia, and the production of antigen-specific antibodies. This study highlights the risk of exposure to a combination of MWCNT with antigen.Key words carbon nanotube; allergic asthma; airway resistance; goblet cell hyperplasia; adjuvant activity Allergic asthma is a chronic type of airway inflammation characterized by reversible airway obstruction and goblet cell hyperplasia associated with elevated levels of allergen-specific immunoglobulin E (IgE).1-3) The prevalence of asthma has increased markedly over the past 3 decades, and may be due to changes in environmental factors, including indoor and outdoor air pollution. 4,5) Relatively few investigations on the environmental exacerbating factors of the pathology have been conducted, although intensive experiments have accumulated evidence regarding the molecular mechanisms of therapeutic targets. The former type of research should be focused on, since large environmental changes may occur throughout the world in the future.Nanotechnology is now advancing at an incredible pace, such that it has created an alternative industrial revolution over the past few years. 6) Consistent with this, the use of engineered nanomaterials has been rapidly increasing in commercial applications. As these materials have become more widespread, many questions have arisen regarding the effects of these materials as inhalable toxicants. Among several different types of nanomaterials, carbon nanotubes (CNT) are one of the most attractive materials because of their unique physical and chemical characteristics, including their size (1-20 nm width and many micrometers in length), strength, and surface chemistry. 7,8) However, CNT show marked cyt...

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Airborne house dust particles and diesel exhaust particles as allergen carriers

Abstract: Soot particles in airborne house dust may act as carriers of several allergens in indoor air. Furthermore, DEP has the ability to bind all the four allergens investigated under aqueous conditions in vitro.

Cited by 101 publications

References 33 publications

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Dynamics (seasonal and intra-diurnal) of air-borne fungal spore population of Doha area, Qatar

Effect of Diesel Exhaust Particles on House Dust Mite–Induced Airway Eosinophilic Inflammation and Remodeling in Mice

Exposure to Multiwalled Carbon Nanotubes and Allergen Promotes Early- and Late-Phase Increases in Airway Resistance in Mice

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