Airflow Limitation, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients

Knobbe, Tim J.; Kremer, Daan; Eisenga, Michele F.; Londen, Marco van; Gomes-Neto, António W; Douwes, Rianne M.; Gan, C. Tji-Joong; Corpeleijn, Eva; Annema, Coby; Navis, Gerjan; Berger, Stefan P.; Bakker, Stephan J. L.; Investigators, TransplantLines

doi:10.2215/cjn.06600521

Cited by 10 publications

(7 citation statements)

References 45 publications

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“…Findings from this review failed to identify a consistent relationship between lung function and fatigue in adults with COPD. However, in a study of adults with chronic kidney disease, airflow obstruction and lung function occurrence were associated with over twice the risk of experiencing severe fatigue, with lower health-related quality of life (Knobbe et al, 2021). Therefore, further research is necessary to differentiate those with varying COPD disease severity and the relationship to varying levels of fatigue severity.…”

Section: Physiologic Factorsmentioning

confidence: 99%

COPD-Related Fatigue: A Scoping Review

et al. 2022

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Millions of people worldwide have chronic obstructive pulmonary disease (COPD), and one of the most common and troublesome symptoms that must be managed is fatigue. While there are existing interventions to address COPD-related fatigue, not all patients experience benefit. A better understanding of the factors associated with COPD-fatigue could elucidate new approaches to address COPD-related fatigue, thereby offering relief to a greater number of patients. The purpose of this review was to identify the physiologic, psychologic, and situational factors associated with COPD-related fatigue. A total of four databases, PubMed, CINAHL, Scopus, and Google Scholar, were searched. Those that were peer reviewed, in English, and published between 2000 and 2021, were included in the review. A total of 25 articles were included in this scoping review. The following factors were related to fatigue in COPD: dyspnea, pain, anxiety, depression, and sleep. Fatigue is a debilitating symptom with factors influential to the symptom and outcomes. Research is indicated to explore targeted and personalized interventions addressing the factors related to fatigue to mitigate this widespread symptom.

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Section: Physiologic Factorsmentioning

confidence: 99%

COPD-Related Fatigue: A Scoping Review

et al. 2022

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“…Concerning the latter, transplant recipients report fatigue as a primary obstacle to sport participation and performance (van Adrichem et al, 2016). Fatigue is also identified as a causal factor for reduced QoL (Anderson & Ferrans, 1997;Knobbe et al, 2021) and despite being a major concern among organ transplant recipients, research and overall understanding of the impact of fatigue on transplant athletes' QoL perceptions continue to be sparse (Wright et al, 2019). Consequently, current post-transplant exercise guidance for professionals working with transplant recipient athletes remains largely askew and unsubstantiated (Hames et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

An Initial Exploration of Fatigue as a Predictor of Quality of Life in Transplant Athletes Competing at National and International Events.

Rogerson¹,

Houghton²,

Hogg³

et al. 2023

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Background: Supporting organ transplant recipients’ quality of life after surgery continues to be of topical interest to health researchers and applied practitioners. However, literature and guidance on the factors linked to quality of life in transplant recipient athletes remains largely unreported and unconfirmed. Aim: Therefore, in this study we sought to identify significant predictors of quality of life in an international sample of organ transplant recipient athletes (N = 99, Mage = 53.12, SD = 13.70). Method: Adopting a cross-sectional design, we collected the study data during the 2019 World Transplant Games using online and pen-and-paper surveys that consisted of demographic items, health, and physical activity-related measures (i.e., Task and Ego Orientation in Sport Questionnaire, Fatigue Severity Scale, Assessment of Physical Activity Questionnaire, Physical Activity Enjoyment Scale). Predictor variables in the study were broadly summarised into three categories namely demographic factors, sport-related factors, and levels of fatigue with physical and mental quality of life functioning as the outcome variables. Results: Hierarchical regression analyses exposed fatigue to exert a significant negative influence on both mental and physical quality of life perceptions explaining 49% and 64% of the variance in these variables respectively. Conclusion: It is recommended that transplant athletes’ level of fatigue should be routinely measured and closely monitored in sport settings as it has a negative bearing on quality of life that may act as a potential barrier to sport participation and enjoyment.

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“…I remain hopeful after reading in the discussion section of the paper that “FEV 1 can be improved by high-intensity aerobic exercise training and the use of bronchodilator medication” (1). I will bring this to the attention of my care team to see if we can reduce my fatigue and therefore improve my quality of life.…”

mentioning

confidence: 99%

“…The article published in this issue of CJASN, “Airflow Limitation, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients,” states that “Many kidney transplant recipients suffer from fatigue and poor health-related quality of life [HRQoL]. Airflow limitation may be an underappreciated comorbidity among kidney transplant recipients” (1). This may be the key to understanding my condition.…”

mentioning

confidence: 99%

“…Consequently, underlying comorbidities are increasingly recognized as key targets to reduce fatigue and increase HRQoL among kidney transplant recipients. We propose that airflow limitation is an important, hitherto overlooked, comorbidity after kidney transplantation” (1). As a type 1 diabetic, having heart disease and vascular issues makes me a prime candidate for airflow limitation.…”

mentioning

confidence: 99%

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