AIRP Best Cases in Radiologic-Pathologic Correlation: Localized Amyloidosis of the Renal Pelvis

Paidy, Sinu; Unold, David; Catanzano, Tara

doi:10.1148/rg.327115157

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…Amyloidosis can be classified as systemic or localised on the basis of the distribution of amyloid deposition. [1][2][3][4] Infrequently, the urinary tract and supporting retroperitoneum are involved and, rarely, the ureter, renal pelvis, and urethra are affected. 3 Clinically, the presenting signs and symptoms include haematuria, ureteric stricture, and hydroureteronephrosis.…”

Section: Introductionmentioning

confidence: 99%

Localised Ureteric Amyloidosis Mimicking Urothelial Tumour

Fung¹,

Wong²,

Kan³

et al. 2014

Hong Kong J Radiol

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Amyloidosis is a pathological process characterised by extracellular deposition of fibrillar protein. Systemic amyloidosis with multiple organ involvement is more common than localised amyloidosis. Localised amyloid deposition in the urinary tract is uncommon and isolated involvement of the ureter and renal pelvis is a rare presentation of this uncommon disease. Primary localised amyloidosis of the renal pelvis and ureter can closely resemble malignancy in its presentation, ureteroscopic appearance, and imaging features. This report is of two patients with primary localised amyloidosis involving the renal pelvis and ureter. Both patients first presented with haematuria with loin pain and urothelial tumour was suspected. Diagnosis was only made by histological analysis. In this article, important aspects of the clinical and imaging findings are discussed and the literature is reviewed.

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Section: Introductionmentioning

confidence: 99%

Localised Ureteric Amyloidosis Mimicking Urothelial Tumour

Fung¹,

Wong²,

Kan³

et al. 2014

Hong Kong J Radiol

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Amyloidosis of the renal pelvis: a harbinger of mammary carcinoma?

Grigor

Munro

2015

BMJ Case Reports

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We describe a rare case of light chain immunoglobulin amyloid (AL) accumulation in the central and lower pole renal calyces. Our patient, a woman aged 60, presented with several episodes of gross haematuria. Radiological imaging detected a filling defect in the left renal pelvis. Rigid ureteroscopy showed a corresponding mucosal abnormality resembling transitional cell carcinoma. A definitive preoperative tissue diagnosis could not be reached. Laparoscopic-assisted left nephroureterectomy was indicated. Histopathological examination excluded malignancy, revealing congophilic deposits of submucosal amyloid. A constellation of findings confirmed localised or primary amyloidosis with an AL immunophenotype but no evidence of clonal B-cell disease in the amyloid-associated lymphoplasmacytic cell infiltrate. Investigation for systemic plasma cell dyscrasia and echocardiography and scintigraphy for visceral amyloid deposits were negative for systemic disease. At a follow-up period of 30 months, there is no recurrence. However, our patient was diagnosed with breast cancer 21 months ago.

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