Airway hyperresponsiveness to adenosine 5’-monophosphate in feline chronic inflammatory lower airway disease

Correlation of bronchoalveolar eosinophilic percentage with airway responsiveness in cats with chronic bronchial disease

“…Increased bronchoreactivity to adenosine 5’‐monophosphate (AMP) has been described among asthmatic cats compared to those with chronic bronchitis (Hirt et al . ) though criteria for classification were different. The results here support the use of C‐Penh‐300, calculated by provocative testing with carbachol, as a means of differentiating feline EB and NEB.…”

“…, Hirt et al . ). Categorization is generally based on eosinophil and neutrophil percentages in bronchoalveolar lavage fluid (BALF).…”

“…Only one previous study has described the use of BWBP to investigate AR in clinical cases (Hirt et al . ).…”

“…, Hirt et al . , Johnson & Vernau ). Efforts to accurately distinguish these conditions remain relevant as future therapeutic targets will likely come from a better understanding of underlying pathophysiological mechanisms (Reinero ).…”

Increased adenosine concentration in bronchoalveolar lavage fluid of horses with lower airway inflammation

“…Administration of adenosine by inhalation induces bronchoconstriction of asthmatic (but not of normal) airways. Recently, adenosine 5′-monophosphate has been shown to have a similar effect on cats affected with chronic airway disease (Hirt et al, 2011). In addition, adenosine modulates the course of inflammation through the release of cytokines and chemokines from various cell types in the airways (Caruso et al, 2009).…”