Airway inflammation in nasal polyposis: immunopathological aspects of relation to asthma

Ediger, Dane; Ba, Sin; Heper, A; Anadolu, Yücel; Mısırlıgil, Zeynep

doi:10.1111/j.1365-2222.2005.02194.x

Cited by 43 publications

(33 citation statements)

References 23 publications

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“…1,2 As has been described before in European and US studies, histology would reveal prominent edema formation and tissue eosinophilia in the vast majority of polyp specimens, the latter being even more pronounced in patients with concomitant asthma, aspirin sensitivity, or both. 3,4 CRSwNP in white subjects has consistently showed a T H 2 polarization with high IL-5 and IgE concentrations and low levels of TGF-b1. 1 Of note, NPs in patients with cystic fibrosis show edema formation and matrix disruption also but display a prominent neutrophilic instead of eosinophilic inflammation and a significantly lower tissue eosinophil cationic protein (ECP) concentration compared with NPs from patients with CRSwNP, suggesting that edema formation might not necessarily be dependent on tissue eosinophils and their activation.…”

mentioning

confidence: 97%

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Zhang

Zele

Pérez-Novo

et al. 2008

Journal of Allergy and Clinical Immunology

562

490

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mentioning

confidence: 97%

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Zhang

Zele

Pérez-Novo

et al. 2008

Journal of Allergy and Clinical Immunology

562

490

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“…In this study, we concomitantly used the oral and the nasal exhaled breath condensate collection to explore the entire upper airway system. The hypothesis that upper airways inflammation can propagate to lower airways in NP has been recently predicted [5]. Lamblin and colleagues described bronchial changes in subjects with NP [6], and subsequent studies confirmed the presence of lower inflammation in NP [27].…”

Section: Discussionmentioning

confidence: 96%

“…Several pro-infiammatory cytokines, such as IL-4 and IL-5 have been implicated in inducing eosinophils production, eliciting tissue damage and finally promoting airway remodelling in NP [4]. It has been recently proposed that nasal polyposis can propagate from upper to lower airways [5]; however, mechanisms binding upper and lower airway inflammation in NP remain poorly understood. Two theories are mainly accepted and include an activation of nasal reflexes, or pulmonary aspiration of nasal contents [6].…”

Section: Introductionmentioning

confidence: 99%

Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

Carpagnano

Carratù

Gelardi

et al. 2016

Monaldi Arch Chest Dis

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Background and Aim. Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome.The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. Methods. Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. Results. Concentrations of oral and nasal exhaled IL- 6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p<0.001) and IL-4 (p<0.05) was observed after polypectomy. Conclusions. We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis.

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“…It has been well documented that BHR is associated with increased numbers of eosinophils and mast cells in the bronchial airway [18]. A previous study also demonstrated that activated mast cells may play an essential role in the development of BHR in children with chronic asthma, which may be dependent on tryptase-induced upregulation of bronchial smooth muscle tone [19].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity

Gao

Fan²,

Wang³

2016

Int Arch Allergy Immunol

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Background: The aim of this study was to explore whether serum baseline tryptase (sBT) levels might be a useful marker not only for the accurate diagnosis of childhood asthma, but also for the prediction of disease severity. Methods: A total of 114 asthmatic children were enrolled in this study, 36 of whom had mild intermittent asthma, 38 had mild persistent asthma, and 40 had moderate to severe persistent asthma. Additionally, 34 age-matched healthy children were enrolled as controls. The sBT levels of these populations were measured using a fluoroenzymeimmunoassay kit. The diagnostic performance of sBT levels and their correlation with asthma severity were systematically investigated using receiver operating characteristic (ROC) analysis and correlation analysis. Results: Children with mild and moderate to severe persistent asthma had significantly increased sBT levels as compared to those with mild intermittent asthma and healthy controls. ROC analysis further demonstrated that sBT levels not only appear to be highly sensitive and specific for distinguishing asthmatic children from healthy controls, but also show good accuracy for the differentiation of various asthmatic subgroups. Correlation analysis revealed that in all asthmatic subgroups sBT levels were significantly correlated with a variety of key markers that reflect the disease severity of asthma, including childhood asthma control test scores, serum IgE and interleukin-13 levels, blood eosinophil counts, and pulmonary test parameters. Conclusions: sBT levels may have a potential use in supporting a diagnosis of asthma in children and as a predictor of disease severity.

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Airway inflammation in nasal polyposis: immunopathological aspects of relation to asthma

Cited by 43 publications

References 23 publications

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity

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