Airways inflammation and glucan exposure among household waste collectors

Thorn, Jörgen; Beijer, Lena; Rylander, Ragnar

doi:10.1002/(sici)1097-0274(199805)33:5<463::aid-ajim5>3.0.co;2-t

Cited by 102 publications

(51 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal and human inhalation studies have suggested that b (1-3) -glucans have inflammatory properties. b (1)(2)(3) -glucans are regarded as a marker of fungal spores, but can also be present in some bacteria and plant material. The response in the airways is different from that induced by inhaled endotoxins.…”

supporting

confidence: 67%

“…The response in the airways is different from that induced by inhaled endotoxins. This probably depends on the structure and physical properties of b (1)(2)(3) -glucans [7]. Animal studies have shown that b (1-3) -glucan exposure causes an eosinophil dominated inflammatory response, which decreases after simultaneous endotoxin exposure [8].…”

mentioning

confidence: 84%

“…Bioaerosols generated from decaying organic waste contain bacteria, bacterial and fungal spores, and microbial components like endotoxins and b (1)(2)(3) -glucans that may induce inflammation [1,2]. Inhalation of endotoxins induces the influx of neutrophils and the production of pro-inflammatory cytokines and biomarkers, which is reflected in airway fluids.…”

mentioning

confidence: 99%

“…Endotoxins are regarded as the most potent inflammatory component in bioaerosols [3]. However, exposure to endotoxins during waste collection is usually low compared with the "no-effect level" for airway inflammation [2][3][4][5][6]. Yet, increased levels of neutrophils and their product, myeloperoxidase (MPO), in the nasal lavage from waste collectors and compost workers were related to the endotoxin exposure during work [1,5].…”

mentioning

confidence: 99%

See 3 more Smart Citations

Airway inflammation in waste handlers exposed to bioaerosols assessed by induced sputum

Heldal¹,

Halstensen²,

Thorn³

et al. 2003

Eur Respir J

View full text Add to dashboard Cite

Work-associated lower airway inflammation in waste collectors was examined by induced sputum and correlated with the bioaerosol exposure.Organic waste collectors (n=25) underwent induced sputum collection and spirometry before work on Monday and the following Thursday. Total cells, cell differentials, interleukin (IL)-8 and eosinophilic cationic protein were determined. Personal full-shift exposure measurements were performed Monday, Tuesday and Wednesday and analysed for total bacteria, fungal spores, endotoxins and b (1-3) -glucans.The percentage of neutrophils (46-58%) and the IL-8 concentration (1.1-1.4 ng?mL

show abstract

supporting

confidence: 67%

mentioning

confidence: 84%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Airway inflammation in waste handlers exposed to bioaerosols assessed by induced sputum

Heldal¹,

Halstensen²,

Thorn³

et al. 2003

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…49,50,51 Inhalation of (1→3)-β-Dglucans has also been associated in some studies with airway inflammation. 49,52,53,54 Table 2 shows the results for microbial sampling before and after ClO 2 treatment. Initial concentrations of culturable fungi in the house were extremely high.…”

Section: Bacteria and Endotoxinmentioning

confidence: 99%

Health hazard evaluation report: HETA #2004-0387-3071, Gro-West, Utica, New York.

2008

View full text Add to dashboard Cite

Upper airway inflammation assessed by nasal lavage in compost workers: A relation with bio-aerosol exposure

et al. 2000

View full text Add to dashboard Cite

Background Exposure to microbial agents in the composting industry may cause work related airway inflammation. Nasal lavage (NAL) has been proposed as a noninvasive method to assess such effects in population studies. Methods Pre‐ and post‐shift NAL were performed in the workers of a compost plant visited in 1995 (n = 14) and 1996 (n=15), of whom only four participated in both surveys. Total cells, cytokines and other inflammation markers were measured in NAL fluid, and pre‐shift levels and post/pre concentration ratios were compared with NAL results obtained in the same periods in 10 and 9 controls, respectively, and with levels of airborne exposure to microbial agents endotoxin and β(1,3)‐glucan as measured in personal air samples. Results Job‐title specific exposure levels in the first survey ranged from 75 to 527 EU/m3 for endotoxin and from 0.54 to 4.85 μg/m3 for β(1,3)‐glucan. In the second survey these values were lower, 29–285 EU/m3 and 0.36–4.44 μg/m3, respectively. In the first survey pre‐shift NAL concentrations of total cells, MPO, IL‐8, NO and albumin were significantly (1.1–4.8 fold) higher in compost workers than in controls. Post/pre ratios for various markers were significantly (1.2–3.2 fold) higher in compost workers in both surveys. NAL cells were mainly neutrophils, while eosinophils were only incidentally observed. A weak relation with exposure was found for pre‐shift levels of MPO, uric acid and urea in the first survey. Conclusions Occupational exposure of compost workers may cause acute and possibly (sub‐)chronic inflammatory reactions in the upper airways, presumably induced by non‐allergenic pro‐inflammatory agents like endotoxins and β(1,3)‐glucans. Am. J. Ind. Med. 37:459–468, 2000. © 2000 Wiley‐Liss, Inc.

show abstract

Airways inflammation and glucan exposure among household waste collectors

Cited by 102 publications

References 21 publications

Airway inflammation in waste handlers exposed to bioaerosols assessed by induced sputum

Airway inflammation in waste handlers exposed to bioaerosols assessed by induced sputum

Health hazard evaluation report: HETA #2004-0387-3071, Gro-West, Utica, New York.

Upper airway inflammation assessed by nasal lavage in compost workers: A relation with bio-aerosol exposure

Contact Info

Product

Resources

About