Airways obstruction in rheumatoid arthritis.

Geddes, Duncan M.; Webley, M; Emerson, Peter A.

doi:10.1136/ard.38.3.222

Cited by 118 publications

(77 citation statements)

References 13 publications

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“…Also, increased production of autoantibodies against a broad spectrum of self-antigens has been demonstrated in COPD, suggesting the role of autoimmunity [12]. Authors from prior studies have also pointed out the possibility of recurrent respiratory infections in RA patients to predispose to airway obstruction [13,14]. …”

Section: Discussionmentioning

confidence: 99%

“…The other mechanism that has been postulated is that the chronic inflammation in RA may lead to alveolar wall destruction by effect on alveolar epithelial cells, ultimately leading to COPD [15] There are studies that have looked at the pulmonary function tests in patients with RA have suggested that RA patients had significantly lower values of FEV1, FVC, and FEV1/FVC- which are the indicators of obstructive lung disease [13,14]. Although restrictive lung disease (interstitial lung disease) is well recognized in RA, the association with COPD has only been evaluated by a handful of studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Dhital

Basnet

Paudel

et al. 2018

Journal of Community Hospital Internal Medicine Perspectives

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Rheumatoid arthritis (RA) is being increasingly recognized as an important contributor to chronic obstructive pulmonary disease (COPD). Although smoking is a major risk factor, other factors may play a role. We used National Inpatient Sample (NIS) from 2013 to explore this relationship. We used propensity matching with a 1:3 nearest-neighbor-matching algorithm to match 1 RA hospitalization to 3 age- and-sex-matched comparators. In the age- and-sex-matched population, RA had a higher odds of COPD (OR 1.20, 95% CI: 1.17–1.22, p < 0.0001).RA is associated with increased COPD prevalence, independent of smoking. COPD might fall within the spectrum of RA complications, likely due to autoimmune and inflammatory mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Dhital

Basnet

Paudel

et al. 2018

Journal of Community Hospital Internal Medicine Perspectives

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show abstract

“…However, diagnostic criteria varied among studies and the choice of criteria has a major effect on epidemiological description. GEDDES et al [76] reported that 32% of patients with rheumatoid arthritis had airflow limitation. TANAKA et al [44] found that 17% of patients had CT scan features suggestive of bronchiolitis.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Small airways diseases, excluding asthma and COPD: an overview

Burgel¹,

Bergeron²,

Blic³

et al. 2013

Eur Respir Rev

105

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This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.

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“…Pulmonary complications are a leading cause of death in patients with RA 8 . Chronic obstructive pulmonary disease with both restrictive lung disease and obstructive lung disease produce clinical symptoms 9,10 . The systemic nature of the disease is manifested by a variety of extraarticular features resulting from involvement of heart, lungs, pleura, eyes etc.…”

Section: Introductionmentioning

confidence: 99%

Pleuropulmonary complications in Rheumatoid Arthritis

Panda¹,

Dash²,

Taranikanti³

2012

Int Jour of Biomed Res

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Rheumatoid Arthritis (RA) is a chronic systemic disease with decreased physical function. It is characterised by both articular and extra-articular manifestations. Pulmonary involvement is common and its complications are a leading cause of death in patients with RA. The present study was undertaken with the objective of analysing the incidence and severity of pleuro pulmonary complications in RA. A cross-sectional study on 36 patients with RA was carried out along with a detailed history, general and systemic examination. A blood picture showing C-Reactive protein and Rheumatoid factor were also done confirm the presence of the disease. Results were analysed using percentages and proportions and significance value. The study has shown that RA is predominantly and significantly (p=0.007) high in females in their fourth decade of life. However, respiratory abnormalities were found to be higher in males than female patients. Dyspnoea, cough and wheeze were among the common complaints whereas pleural rub was the most common clinical finding on examination. Early detection of respiratory involvement is interfered with due to physical deconditioning of the patient due to joint involvement.

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Airways obstruction in rheumatoid arthritis.

Cited by 118 publications

References 13 publications

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Small airways diseases, excluding asthma and COPD: an overview

Pleuropulmonary complications in Rheumatoid Arthritis

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