Akkermansia muciniphila and host interaction within the intestinal tract

Карамзин, А. М.; Ropot, Anastasiia V.; Сергеев, О. В.; Khalturina, E. O.

doi:10.1016/j.anaerobe.2021.102472

Cited by 13 publications

(7 citation statements)

References 103 publications

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“…WPI-GA-ZD consumption significantly increased the relative abundances of Lachnospiraceae, Verrucomicrobiaceae and Ruminococcaceae. The relative abundance of the Verrucomicrobiaceae family, to which the Akkermansia genus is subordinated, has been reported to be inversely correlated with the inflammation activity in individuals with IBD [ 34 ]. Lachnospiraceae and Ruminococcaceae are the main butyrate producers residing in the intestinal microbiota [ 26 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a specifically efficient mucin-degrading bacterium, Akkermansia can produce acetate and propionate using intestinal mucins, thus contributing to intestinal health and glucose homeostasis. Besides, this bacterium could improve intestinal integrity by activating AMP-activated protein kinase to regulate the expression of tight junction proteins [ 34 ]. Some carotenoids, such as astaxanthin and fucoxanthin, have been reported to ameliorate local and systemic inflammation in mice by enhancing the abundance of Akkermansia [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Zeaxanthin Dipalmitate-Enriched Emulsion Stabilized with Whey Protein Isolate-Gum Arabic Maillard Conjugate Improves Gut Microbiota and Inflammation of Colitis Mice

Kan

Zhou

et al. 2022

Foods

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In the present study, protein-polysaccharide Maillard conjugates were used as novel emulsifiers and bioactive carriers. Effects and potential mechanisms of zeaxanthin dipalmitate (ZD)-enriched emulsion stabilized with whey protein isolate (WPI)-gum Arabic (GA) conjugate (WPI-GA-ZD) and ZD-free emulsion (WPI-GA) on gut microbiota and inflammation were investigated using a model of dextran sulfate sodium (DSS)-induced colitis in mice. As a result, supplementation with WPI-GA and WPI-GA-ZD improved the serum physiological and biochemical indicators, decreased the expression of pro-inflammatory cytokines and related mRNA, as well as increased the tight junction proteins to a certain extent. 16S rDNA sequencing analyses showed that supplementation with WPI-GA and WPI-GA-ZD presented differential modulation of gut microbiota and played regulatory roles in different metabolic pathways to promote health. Compared with WPI-GA, the relative abundances of Akkermansia, Lactobacillus and Clostridium_IV genera were enriched by the intervention of WPI-GA-ZD. Overall, the designed carotenoid-enriched emulsion stabilized with protein-polysaccharide conjugates showed potential roles in promoting health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zeaxanthin Dipalmitate-Enriched Emulsion Stabilized with Whey Protein Isolate-Gum Arabic Maillard Conjugate Improves Gut Microbiota and Inflammation of Colitis Mice

Kan

Zhou

et al. 2022

Foods

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“…Copy@ Rodney R Dietert Facilitates necessary infant immune maturation; reduces inappropriate inflammation; protects against the risk of later-life allergic diseases [28][29][30] Akkermansia muciniphila Gut Regulates mucin production/turnover and protects integrity of the gut lining [31,32] Combinations of specific Bifidobacteria strain and Lactobaccilus strains Gut Stress resiliency and protection against anxiety [33] Lactobacillus spp.…”

Section: American Journal Of Biomedical Science and Researchmentioning

confidence: 99%

“…(Table 1) [28][29][30][31][32][33][34][35][36][37][38][39] Illustrates examples of key microbes in different body location that carry out significant function for the whole human.…”

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confidence: 99%

The Earth-Connected Human Superorganism Vs. The Machine

Dietert

2022

AJBSR

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The attack extends beyond humans to include the microbiomes of animals (e.g., honeybees), soil, and plants. Despite remarkable human resiliency, the attack leaves many weak, sick, and increasingly reliant on prescription drugs just to stay alive. Two diametrically opposed paths are at hand. In the first, restoration of the human superorganism and increasing development of superorganism capacities leads us to improved health, less reliance on pharmaceuticals, and a nature-based connection (the microbial internet) here on Earth. In the second, the core belief that humans are inadequate to live and thrive on Earth prevails, and it leads us away from humanity and self-determination to existence as a programmable/hackable machine. Instead of being the embodied repository of Earth's life, we become just another icon/device appearing on a computer screen. This opinion article discusses our present fork in the road.

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“…Akkermansia muciniphila is one of many highly abundant human intestinal microbes that may have the ability to significantly influence homeostasis and metabolic disorders [ 1 , 2 ]. For example, some evidence has demonstrated that decreased abundance of the mucin-degrading Akkermansia allows for dysbiosis among other microbial competitors that negatively affect host metabolic syndrome and immune system responses [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Prevalence of Akkermansia muciniphila Differs among Pediatric and Adult Orthodontic and Non-Orthodontic Patients

et al. 2023

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Akkermansia muciniphila (AM) is one of many highly abundant intestinal microbes that influences homeostasis and metabolic disorders and may also play a role in oral disorders. However, there is little evidence regarding the oral prevalence of this organism. Based upon this lack of evidence, the primary goal of this project is to survey an existing saliva repository to determine the overall prevalence of this organism and any associations with demographic or patient characteristics (age, sex, body mass index, race/ethnicity, orthodontic therapy). Using an approved protocol,, a total n = 141 pediatric samples from an existing saliva repository were screened using qPCR revealing 29.8% harbored AM with nearly equal distribution among males and females, p = 0.8347. Significantly higher percentages of pediatric, non-orthodontic patients were positive for AM (42.3%) compared with age-matched orthodontic patients (14.3%)—which were equally distributed among non-orthodontic males (42.1%) and non-orthodontic females (42.5%). In addition, analysis of the adult samples revealed that nearly equal percentages of males (18.2%) and females (16.7%) harbored detectable levels of salivary AM, p = 0.2035. However, a higher proportion of non-orthodontic adult samples harbored AM (21.3%) compared to orthodontic samples (12.8%, p = 0.0001), which was equally distributed among males and females. These results suggest that both age and the presence of orthodontic brackets may influence microbial composition and, more specifically, are associated with reduction in AM among both pediatric and adult populations from their baseline levels.

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Akkermansia muciniphila and host interaction within the intestinal tract

Cited by 13 publications

References 103 publications

Zeaxanthin Dipalmitate-Enriched Emulsion Stabilized with Whey Protein Isolate-Gum Arabic Maillard Conjugate Improves Gut Microbiota and Inflammation of Colitis Mice

Zeaxanthin Dipalmitate-Enriched Emulsion Stabilized with Whey Protein Isolate-Gum Arabic Maillard Conjugate Improves Gut Microbiota and Inflammation of Colitis Mice

The Earth-Connected Human Superorganism Vs. The Machine

Oral Prevalence of Akkermansia muciniphila Differs among Pediatric and Adult Orthodontic and Non-Orthodontic Patients

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