Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

Zhang, Hongsheng; Weiwei, Sang; Ruan, Zheng; Wang, Yu-Ou

doi:10.1016/j.abb.2010.10.018

Cited by 29 publications

(22 citation statements)

References 44 publications

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“…3B; supplementary material Fig. S2) -proved similarly responsive; this is consistent with reports suggesting HIV responds to TNFa through binding of NFkB to the long terminal repeat (Sgarbanti et al, 2008;Zhang et al, 2011). In contrast, the number of foci obtained with the nonresponsive ACTB promoter does not change substantially upon stimulation (supplementary material Fig.…”

Section: Systematic Analysis Of Human Promoters Reveals An Effect On supporting

confidence: 78%

Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites

Larkin

Papantonis

Cook

2013

Journal of Cell Science

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SummaryBoth the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision' localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest how such spatial co-association might drive co-regulation of genes under the control of similar cis-elements.

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Section: Systematic Analysis Of Human Promoters Reveals An Effect On supporting

confidence: 78%

Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites

Larkin

Papantonis

Cook

2013

Journal of Cell Science

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“…EGCG induces expression of GPx, glutamate cysteine ligase, and heme oxygenase-1, which are all involved in the elimination or inactivation of ROS (Na and Surh, 2008), and these effects are mediated by activation of Nrf2 (Romeo et al, 2009). Tat caused oxidative stress, including ROS production and depletion of intracellular GSH cells in MAGI cells (Zhang et al, 2011b). As an antioxidant response-related transcription factor, Nrf2 could inhibit HIV-1 transactivation through inducing expression of antioxidant gene expression .…”

Section: Discussionmentioning

confidence: 98%

“…As we have previously shown, p65 phosphorylation and IKK phosphorylation had been related to NF-κB activation in MAGI cells (Zhang et al, 2011b). In order to determine whether the effect of EGCG on HIV-1 transactivation was due to suppression of NF-κB activation, we investigated the effects of EGCG on NF-κB activation in MAGI cells.…”

Section: Effects Of Egcg On Tat-induced Ros Production and Depletion mentioning

confidence: 96%

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EGCG inhibits Tat-induced LTR transactivation: Role of Nrf2, AKT, AMPK signaling pathway

Zhang

Weiwei

et al. 2012

Life Sciences

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“…Generally these studies demonstrated that the proportion of Fasexpressing cells increases with disease progression. Increased Fas expression in CD4+ lymphocytes was found by some investigators and others were found in both CD4+ and CD8+ T cells [50,51].…”

Section: Oxidative Stress In Hiv Natural Infectionmentioning

confidence: 99%

Altered Redox Regulation as Cofactor in Comorbidities and Accelerated Aging in HIV Infection Evolution and Antiretroviral Treatment

Valle¹

2014

Epidemiol

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Metabolic issues persist in HIV patients who are otherwise stable with and without antiretroviral treatment. Metabolic alterations are associated to chronic inflammation, severe mitochondrial toxicity and oxidative stress as critical factors influencing HIV disease outcomes even during antiretroviral treatment. These aspects could also be involved in comorbidities and premature aging. Both factors should be managed during therapy and they should be focus of intense ongoing investigation.The aim of this mini-review is to describe essential mechanisms of in vivo reactive oxygen species generation, antioxidants pathways, and oxidative stress involved in HIV disease. Potential impact on reactive oxygen species, oxidative damage, cellular function, and how these responses change could mediate aging in pathophysiological situations are discussed. Accrual experimental and clinical reports analyses allow us a better understanding of various inter-related contributing factors. In addition, oxidative stress as an often-overlooked link between HIVinfection and the progression of aids, during antiretroviral treatment, is analyzed. Potential long-term consequences of antioxidant treatment require on-going investigation in order to obtain important clinical issues that have recently been reported. Currently, the most practical advice is to start antiretroviral therapy early and to manage traditional risk factors of non-aids-related conditions.

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Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

Cited by 29 publications

References 44 publications

Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites

Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites

EGCG inhibits Tat-induced LTR transactivation: Role of Nrf2, AKT, AMPK signaling pathway

Altered Redox Regulation as Cofactor in Comorbidities and Accelerated Aging in HIV Infection Evolution and Antiretroviral Treatment

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